A5064123672- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Biomedical Research and Pathophysiology
- Trace Elements in Health
Hospital for Sick Children
2021-2022
First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common multiple modes tissue The molecular that mediates cytoprotection, however, remains elusive. Here, we show works at the level NINJ1, newly identified executioner plasma membrane in pyroptosis, necrosis, post-apoptosis lysis. NINJ1 is thought cluster within cause cell rupture. We...
Abstract First recognized 35 years ago, glycine is known to protect cells against plasma membrane rupture from diverse types of tissue injury. This robust and widely observed effect has been speculated target a late downstream process common multiple modes The molecular cytoprotection, however, remains entirely elusive. We hypothesized that targets ninjurin-1 (NINJ1), newly identified executioner in pyroptosis, necrosis, post-apoptotic cell death. NINJ1 thought cluster within the cause...