A5072630612- Esophageal Cancer Research and Treatment
- Sarcoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Neurofibromatosis and Schwannoma Cases
- Lymphoma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- COVID-19 and Mental Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations and Hemangiomas
- Neurosurgical Procedures and Complications
- Photodynamic Therapy Research Studies
- Ocular Oncology and Treatments
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- Drug-Induced Adverse Reactions
- Psychosomatic Disorders and Their Treatments
- Brain Metastases and Treatment
- Genital Health and Disease
- Renal and related cancers
Keio University Hospital
2024-2025
Keio University
2021-2025
Over 50% of patients with high-grade serous carcinoma (HGSC) are homologous recombination proficient, making them refractory to platinum-based drugs and poly (ADP-ribose) polymerase (PARP) inhibitors. These often develop progressive resistance within 6 months after primary treatment tend die early, thus new therapies urgently needed. In this study, we comprehensively investigated tumor type by leveraging a combination machine learning analysis large published dataset newly developed...
Precursor lesions may be identified in fallopian tube tissue after risk-reducing salpingo-oophorectomy (RRSO) patients with pathogenic variants of BRCA1/2. Serous tubal intraepithelial carcinoma (STIC) is considered a precursor high-grade serous carcinoma, whereas the significance p53 signature remains unclear. In this study, we investigated relationship between and risk ovarian cancer.We analyzed clinicopathological findings conducted DNA sequencing for TP53 signatures STIC isolated using...
Abstract Drug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug adverse skin eruption visceral organ involvement. The characteristic clinical features of DIHS/DRESS are reactivation human herpesviruses (HHV) the development autoimmune diseases, but their pathogenesis associations not yet understood. Here, we report 66‐year‐old man who presented fever, generalized erythema, diffuse lymphadenopathy, diarrhea after 3 weeks...
Abstract Background Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma mainly treated via surgical resection. Herein, we report case of MPNST wherein massive thrombus extended to the major veins and heart. Case presentation A 39-year-old female with history neurofibromatosis type 1 developed from right radial nerve. In addition adjuvant chemotherapy, she underwent wide resection concomitant resection, followed by postoperative radiotherapy. Histological evaluation...
We performed surgical treatment for cerebellar metastasis of relatively rare small-cell neuroendocrine carcinoma (SCNC) the urinary bladder. On preoperative imaging, lesion was solitary, and edema around tumor unremarkable; thus, other differential diagnoses besides a metastatic brain were also considered preoperatively. Intraoperatively, soft, circumference boundary indistinct easily hemorrhagic. The grossly totally removed, postoperative radiotherapy added. clinical symptoms patient...
背景:子宮頸部腺扁平上皮癌と小細胞癌はまれな腫瘍である.今回,腺扁平上皮癌いわゆる "すりガラス細胞癌" と小細胞癌が共存した子宮頸癌の 1 例を経験したので報告する.
Chronic encapsulated intracerebral hematoma (CEIH) is a rare cerebrovascular disease featuring progressively expanding intracranial hematoma. We treated man in his 70s with bilateral cerebellar CEIH. He had presented at another hospital dizziness, and imaging showed two independent hemorrhagic space-occupying lesions the hemispheres. The symptoms progressed relatively rapidly, there were signs of impending herniation; he was transferred to our institution, emergency surgery performed....
77歳，男性．初診3ヶ月前から右鼠径部の皮疹に気づき，増大傾向のため切除目的に当科を受診した．右鼠径部に径1 cm大の境界明瞭な紅色結節を認め，結節の表面は角化を認めず，一部浸軟し乳頭腫状を呈した．病理組織像は，乳頭腫状の表皮変化を呈し，過角化，不規則な表皮肥厚を認めた．表皮全層に有棘細胞様の異型細胞が増殖し，核腫大，異型分裂像，細胞の大小不同を認めた．コイロサイトーシスを認めず，異型細胞の真皮内浸潤を認めなかった．免疫組織染色において，p16 INK4aは表皮異型細胞の核と細胞質に陽性を示した．ボーエン様丘疹症と診断し，有棘細胞癌に準じて腫瘍の辺縁より5 mm離して病変を全摘した．切除断端に腫瘍細胞の残存はなく，2年間経過した時点では再発を認めない．切除組織よりHuman papillomavirus （HPV）のDNA検査を行い，HPV...
Abstract Purpose: Primary central nervous system (CNS) rhabdomyosarcomais a rare mesenchymal tumor predominantly seen in children and associated with poor outcome. We report case of primary CNS rhabdomyosarcoma PAX3-NCOA2 fusion presenta systematic meta-review to characterize this tumor. Methods: present the 6-year-old boy posterior fossa. In meta-review, we compare demographic data at all sites from SEER database analyze clinical factors survival Results: Our patient underwent gross total...