A5057558569- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Immune responses and vaccinations
- Supramolecular Self-Assembly in Materials
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- RNA Interference and Gene Delivery
- Pharmaceutical Economics and Policy
- CO2 Sequestration and Geologic Interactions
- Bioactive Compounds in Plants
- Lung Cancer Diagnosis and Treatment
- Polydiacetylene-based materials and applications
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Amino Acid Enzymes and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Pharmacological Receptor Mechanisms and Effects
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Pharmaceutical industry and healthcare
Australian Regenerative Medicine Institute
2023
Monash University
2023
The University of Melbourne
2020-2021
University of Nottingham
1974-1978
Cancer Research UK
1976
Adjuvant contact therapy with BCG can be used to control tumor deposits at local subcutaneous sites and other sites, particularly pulmonary metastases pleural growths. This treatment method is generally quantitatively more effective than general immunostimulation, or active immunotherapy that employs vaccines of adjuvant cells. Furthermore, this in hosts lack full immunocompetence, making it still feasible immunosuppressed patients. The current evidence indicates activation host macrophages...
A synthetic strategy for conjugating small molecules and peptide-based therapeutics, via a cleavable ester bond, to lipidated β3-tripeptide is presented. The drug-loaded β3-peptide was successfully co-assembled with functionally inert form hydrogel. Quantitative release of lactose from the hydrogel, by action serum esterases, demonstrated over 28 days. esterase-mediated sustained bioactive brain-derived neurotrophic factor (BDNF) peptide mimics hydrogel resulted in increased neuronal...
Abstract Growth of syngeneic transplants methylcholanthrene‐induced sarcomas and an aminoazo‐dye‐induced hepatoma in rats was suppressed when tumour cells were injected admixture with BCG vaccine containing living organisms, or sterilized by exposure to 1 3 × 10 6 R γ‐irradiation. Rejection mixed inocula viable radiation‐killed induced immunity further challenge cells. Also pulmonary growth produced intravenous injection sarcoma controlled BCG. These studies indicate that...
The chemical synthesis of cyclic peptides is a well-established area research. This has been further expanded by development bio-orthogonal reactions that enable access to greater structural complexity. One approach utilizes 1,3-dichloroacetone selectively link free cysteine side-chains with an acetone-like bridge via SN2 reaction. Here, we have used this reaction dimerize peptide monomers create novel bicyclic dimeric peptides. We investigated range parameters identify the optimal...
Obesity is one of the most prevalent metabolic diseases in Western world and correlates directly with glucose intolerance insulin resistance, often culminating Type 2 Diabetes (T2D). Importantly, our team has recently shown that TNF superfamily (TNFSF) member protein, TNFSF14, been reported to protect against high fat diet induced obesity pre-diabetes. We hypothesized mimics TNFSF14 may therefore be valuable as anti-diabetic agents. In this study, we use silico approaches identify key...
Abstract Six transplanted rat tumours (three mammary carcinomas and three fibrosarcomas), all of spontaneous origin limited immunogenicity, have been examined for susceptibility to immunotherapy with BCG (Glaxo). Growth numbers cells from five was suppressed when were injected subcutaneously in admixture organisms. There no clear correlation between the immunogenicity tumour lines their regionally applied BCG. Active specific immunotherapy, using vaccines viable or radiation‐attenuated BCG,...
Small tripeptides composed entirely of β3-amino acids have been shown to self-assemble into fibres following acylation the N-terminus. Given use Fmoc as a strategy initiate self-assembly in α-peptides, we hypothesized that acyl cap can be replaced by an without perturbation and enable simpler synthetic protocols. We therefore N-acyl for group herein show these Fmoc-protected β3-peptides produce regular spherical particles, rather than fibrous structures, are stable capable encapsulating...