A5086370552- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
National Taiwan University
2021-2025
Multipotent mesenchymal stem/stromal cells (MSCs) exhibit great potential for cell-based therapy. Proper epigenomic signatures in MSCs are important the maintenance and subsequent differentiation potential. The DNA methyltransferase 3-like (DNMT3L) that was mainly expressed embryonic stem (ES) developing germ plays an role shaping epigenetic landscape. Here, we report reduced colony forming ability impaired vitro osteogenesis Dnmt3l -knockout-mice-derived ( KO MSCs). By comparing...
Abstract Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis the main cause for hepatic ageing. Caloric restriction (CR) a promising therapeutic approach to reduce liver. The present study aimed investigate effect of early onset CR on decelerating progression ageing-related steatohepatitis. potential mechanisms regarding mitochondria were further evaluated. Eight-week-old C57BL/6 male mice (n = 21) randomly divided into three groups, Young-AL...