The article provides an analysis of global trends and new areas assessment methodology for helath risk caused by exposure to chemicals, environmental pollutants as well the contemporary issues national methodology.Most details are considered: evidence base, modern methods problems carcinogenic assessment, hygienic regulation based on economic aspects methodology.Particular attention is paid reasons recent years perceived gaps in Russian methodological basis best foreign samples.The urgent...

Introduction. The object of the study is results obtained during implementation Federal Project (FP) “Clean Air” in 2020 supervised participating cities and assessment possibility implementing tasks set for Rospotrebnadzor effective health risk management, reducing morbidity mortality population. purpose to assess public according summary calculations atmospheric air pollution Cherepovets, Lipetsk, Omsk, Novokuznetsk FP (baseline, 2017). Materials methods. primary approach use initial data...

Estrogens play a considerable role in maintaining bone and articular cartilage homeostasis. Menopause provokes joint disorders due to metabolic syndrome altered signaling pathways. Phytoestrogen resveratrol was demonstrated provide chondroprotective osteoprotective effects. However, the mechanisms of such action Resveratrol are still being explored. The study aims determine effect on joints its therapeutic mechanism ovariectomized rats. carried out Wistar female rats that were divided into...

Introduction. The Russian hygienic standardization system of chemical compounds in water, providing the criteria for harmful effects not only on humans, but also sanitary state water bodies, assumes value general index which differs local and international approaches to water. Aim research. Justification differentiated standards various types management delivery algorithm updating substances with harmfulness basis contemporary data their hazard. Materials methods. research material included...

Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with hyaluronic acid (HA) improve pharmacokinetic properties. The study aimed assess the impact of R-HA on system in ovariectomized rats. Methods: was carried out Wistar female It investigated body weight, tail temperature, pH, estrogen progesterone blood levels,...

Microplastics pollution of water bodies and drinking is a relevant problem caused by wide use plastics in multiple industries, agriculture, manufacturing household chemicals medicines. pose threat for human health both due to physical effects their structure as well microorganisms that can occur on surface. Some foreign studies describe how microplastics are formed they marine fresh water. There also confirming be present seas rivers the Russian Federation. Studies address tissues organisms...

Certain essential and conditionally natural elements (selenium, chromium, iodine, molybdenum, cobalt, vanadium, fluorine, lithium, silicon, boron, bromine) are standardized in terms of their contents drinking water as per sanitary-toxicological parameters adverse health effects. Our research goal was to determine a contribution made by into supplying human body with well substantiate the necessity update standards regarding these substances. We applied calculation models for dose equivalents...

The chemical risk assessment is essesntial part of new legislation registration, evaluation, and authorization chemicals (REACH). article presents a review policies in the European Union (EU) Russia, changes regulations to meet requirement REACH. paradigm, toxicological parameters, safe limits classification criteria used by different agencies authorities countries are reported. Our investigation also focuses on comparison OECD member Russia. Tendencies harmonization accordance with globally...

Introduction. Oxidizing methods are most widely used for water disinfection with such reagents as chlorine, chlorine dioxide, sodium, and calcium hypochlorite. However, the regulatory instruments of sanitary epidemiologic legislation do not fully reflect requirements monitoring their use. Materials methods. We analyzed research, methodological literature concerning issues in process treatment parameters efficiency well quality drinking three stations based on production control data (Perm,...

Introduction. In 2019-2020 as part of the implementation “regulatory guillotine” mechanism, there was revised or canceled a number regulatory requirements including those related to rationing various types water. The purpose work eliminate outdated that do not meet modern conditions for ensuring sanitary and epidemiological well-being in field water use population. Materials methods. research materials hygienic regulation waters were rules norms drinking, domestic cultural use, maximum...

Microplastics pollution of water bodies and drinking is a relevant problem caused by wide use plastics in multiple industries, agriculture, manufacturing household chemicals medicines. pose threat for human health both due to physical effects their structure as well microorganisms that can occur on surface. Some foreign studies describe how microplastics are formed they marine fresh water. There also confirming be present seas rivers the Russian Federation. Studies address tissues organisms...

Introduction. The growth of the anthropogenic pollution water bodies and regulation river flow has led to an almost universal intensification eutrophication bodies, which contributes mass development (“blooming “) in summer cyanobacteria - blue-green algae. main danger “ blooming is ability produce toxins adversely affect human health, among hepatotoxin microcystin-LR takes first place prevalence toxicity. To date, drinking regulated by WHO 22 States, but Russia, not standardized. purpose...

Increased competition between producers has now become one of the critical features country’s economy. Within framework Water Strategy Russian Federation, technological issues play a significant role both in protection water resources and compliance with safety requirements favourable quality used. For more than 20 years worldwide, there been transition from hazard-oriented to risk-oriented approach organization nature activities. The use risk-based determines mandatory monitoring all...

Regulatory documents on environmental protection adopted in Russia and abroad often contradict each other as regards terms requirements.It is even more so case of subordinate legislation which doesn't fully conform to international requirements not sufficient when it comes legal people the environment from sources chemical threats.Our research goal was compare Russian validate our suggestions their harmonization.Such a concept "target" quantitative characteristic for those threats health are...

Environmental quality management requires the compliance with a number of conditions, such as use criteria for reliable assessment health effects harmful environmental factors (eg., hygienic standards, risk indices) and optimization laboratory control, including chemicals. The A.N. Sysin Research Institute Human Ecology Health (now part Federal State Budgetary Institution “Centre Strategic Planning Management Biomedical Risks”) Ministry Russian Federation has corrected domestic standards...

Отечественные и зарубежные руководящие документы в области охраны окружающей среды не согласованы противоречивы отношении терминов требований.Еще большей мере это касается подзаконных актов, которые к тому же полной соответствуют международным требованиям, а часто недостаточны правовой защищенности человека от источников химической опасности.Цель исследованиясравнение международных отечественных документов обоснование предложений по их гармонизации.Понятие «целевой показатель» является...

Introduction. Analysis and generalization of the results scientific research institutions Federal Service for Supervision in Protection Rights Consumer Man Wellbeing (Rospotrebnadzor)institutions a hygienic profile are extremely important substantiation ensuring sanitary epidemiological well-being managing risks to health Russian population. The purpose study is analyze results, achievements prospects population Federation. Materials methods. An expert-analytical was carried out. analysis...

The occurrence and distribution of bivalves Sinanodonta woodiana (Lea, 1834) Corbicula fluminea (O. F. Müller 1774), also the white-fingered mud crab (Dutch crab, Harris crab) Rhithropanopeus harrisi tridentata Maitland Chinese mitten Eriocheir sinensis H. Milne Edwards (Crustacea=Decapoda) being new species for fauna Ukraine in Ukrainian part Danube delta are discussed.

Intensive production and use of medicines (drugs) leads to their release into the environment. To assess situation determine tactics safe handling this type medical waste, it is necessary legislative regulation issue. In analytical review there were analyzed currently in force regulatory documents concerning treatment pharmaceutical waste proper disposal. The relevant European standards recommendations are given. A number contradictions unresolved issues have been identified. analysis...

The article is devoted to the history of hygienic regulation harmful chemicals in water at A.N. Sysin Research Institute, spanning several decades. details stages development methodology for water, starting from first regulatory documents developed under guidance 1940s an improved that includes accelerated and in-depth toxicological experiments. step-by-step scheme combines experimental method substantiating maximum allowable concentrations (MACs) based on organoleptic general sanitary...