A5005610402- Autism Spectrum Disorder Research
- Child Development and Digital Technology
- Assistive Technology in Communication and Mobility
- Family and Disability Support Research
- Genetics and Neurodevelopmental Disorders
- EEG and Brain-Computer Interfaces
- Cerebral Palsy and Movement Disorders
- Tactile and Sensory Interactions
- Behavioral and Psychological Studies
- Attention Deficit Hyperactivity Disorder
- Virology and Viral Diseases
- Gaze Tracking and Assistive Technology
- Social Robot Interaction and HRI
- Child Nutrition and Feeding Issues
- Genomics and Rare Diseases
- Infant Health and Development
- Hemispheric Asymmetry in Neuroscience
- Heart Rate Variability and Autonomic Control
- Multisensory perception and integration
- Technology Use by Older Adults
- AI in Service Interactions
- Innovative Teaching and Learning Methods
- Neurogenetic and Muscular Disorders Research
- Obsessive-Compulsive Spectrum Disorders
- Williams Syndrome Research
Center for Autism and Related Disorders
2015-2024
Vanderbilt University Medical Center
2018-2024
Vanderbilt University
2012-2022
John F. Kennedy Center for the Performing Arts
2011-2021
Kennedy Center
2019
Abstract To capture the full spectrum of genetic risk for autism, we performed a two-stage analysis rare de novo and inherited coding variants in 42,607 autism cases, including 35,130 new cases recruited online by SPARK. We identified 60 genes with exome-wide significance ( P < 2.5 × 10 −6 ), five NAV3 , ITSN1 MARK2 SCAF1 HNRNPUL2 ). The association is primarily driven loss-of-function (LoF) variants, an estimated relative 4, consistent moderate effect. Autistic individuals LoF four...
Emerging technology, especially robotic has been shown to be appealing children with autism spectrum disorders (ASD). Such interest may leveraged provide repeatable, accurate and individualized intervention services young ASD based on quantitative metrics. However, existing robot-mediated systems tend have limited adaptive capability that impact individualization. Our current work seeks bridge this gap by developing an technology for ASD. The system is composed of a humanoid robot its vision...
Autism Spectrum Disorders (ASD) are characterized by atypical patterns of behaviors and impairments in social communication. Among the fundamental ASD population challenges appropriately recognizing responding to facial expressions. Traditional intervention approaches often require intensive support well-trained therapists address core deficits, with many having tremendous difficulty accessing such care due lack available trained as well costs. As a result, emerging technology virtual...
It has been argued that clinical applications of advanced technology may hold promise for addressing impairments associated with autism spectrum disorders. This pilot feasibility study evaluated the application a novel adaptive robot-mediated system capable both administering and automatically adjusting joint attention prompts to small group preschool children disorders (n = 6) control 6). Children in groups spent more time looking at humanoid robot were able achieve high level accuracy...
Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental disorder with enormous individual and social cost. In this paper, novel virtual reality (VR)-based driving system was introduced to teach skills adolescents ASD. This capable of gathering eye gaze, electroencephalography, peripheral physiology data in addition performance data. The objective paper fuse multimodal information measure cognitive load during such that tasks can be individualized for optimal skill learning....
Children with autism spectrum disorders (ASD) often exhibit impairments in communication and social interaction, thus face various challenges collaborative activities. Given the cost of ASD intervention lack access to trained clinicians, technology-assisted has gained momentum recent years. In this paper, we present a novel virtual environment (CVE)-based interaction platform for intervention. The development CVE technology may lead creation low-cost that will foster collaboration peers...
Autism spectrum disorder (ASD) impacts 1 in 68 children the U.S., with tremendous individual and societal costs. Technology-aided intervention, more specifically robotic has gained momentum recent years due to inherent affinity of many ASD towards technology. In this paper we present a novel robot-mediated intervention system for imitation skill learning, which is considered core deficit area ASD. The Robot-mediated Imitation Skill Training Architecture (RISTA) designed such manner that it...
The increased prevalence of autism spectrum disorder and documented benefits early intensive intervention have created a need for flexible systems determining eligibility autism-specific services. This study evaluated the effectiveness training program designed to enhance identification assessment within community pediatric settings across state. Twenty-seven providers participated in regional trainings 3.5-year period. Trainings provided clinicians with strategies conducting relatively...
Early intervention can significantly improve long-term outcomes for children with autism. Unfortunately, many do not receive early services due to a critical shortage of trained professionals in this area. To bridge gap, we evaluated Web-based parent training tutorial (Enhancing Interactions), based on evidence-based practices and utilizing the platform maximize learning.Twenty-three parents child between 18 months 6 years an autism spectrum disorder participated. Pre- posttest scores...
In addition to social and behavioral deficits, individuals with Autism Spectrum Disorder (ASD) often struggle develop the adaptive skills necessary achieve independence. Driving intervention in ASD is a growing area of study, but it still widely under-researched. We present development preliminary assessment gaze-contingent virtual reality driving simulator that uses real-time gaze information adapt environment aim providing more individualized method intervention. conducted small pilot...
Difficulties in social interaction, verbal and non-verbal communications as well repetitive atypical patterns of behavior, characterizes Autism spectrum disorders (ASD). A number studies indicated that many children with ASD prefer technology this preference can be explored to develop systems may alleviate several challenges traditional treatment intervention. As a result, recent advances computer robotic are ushering innovative assistive technologies for The current work presents design,...
Many children with Autism Spectrum Disorder (ASD) exhibit atypical gaze behaviors related to joint attention, a fundamental social-communication skill. Specifically, ASD1 show differences in the skills of sharing and following. In this work we present novel virtual reality (VR)-based system, called InViRS, which ASD play games allowing them practice InViRS has three main design contributions: (i) closed-loop attention paradigm real-time tracking participant's eye game performance measures,...
Research suggests that many individuals with autism spectrum disorder (ASD) often demonstrate challenges providing appropriate levels of information during conversational interchanges. Considering the preference ASD, and recent rapid technological advances, robotic systems may yield promise in promoting certain aspects conversation interaction such as self-disclosure personal information. In current work, we evaluated disclosures events specific emotional content across two differing...
Technological agents could be effective tools to used in interventions for enhancing social orienting some young children with ASD. We examined response bids preschool ASD and typical development (TD) at a very early age (i.e., around 3 years) using prompts presented by technological of various forms human comparisons. Children demonstrated less overall compared TD controls, across or human. They responded more often simple humanoid robot the avatar These results support potential...
Driving is essential for many people in developed countries to achieve independence. Individuals with Autism Spectrum Disorder (ASD), addition having social skill deficits, may experience difficulty learning drive due deficits attention-shifting, performing sequential tasks, integrating visual-motor responses, and coordinating motor response. Lacking confidence feeling anxiety further exacerbates these concerns. While there a growing body of research regarding assessment driving behavior or...
Employment outcomes for autistic 1 individuals are often poorer relative to their neurotypical (NT) peers, resulting in a greater need other forms of financial and social support. While great deal work has focused on developing interventions children, relatively less attention been paid directly addressing the employment challenges faced by adults. One key impediment securing is job interview. Autistic experience anxiety interview situations, particularly with open-ended questions unexpected...
Autism Spectrum Disorders (ASD) impact 1 in 88 children the United States. The cost of ASD intervention is tremendous with huge individual and social consequences. In recent years, robotic systems have been introduced considerable success for because their potential to engage ASD. this work, we present a novel closed-loop autonomous system imitation skill learning intervention. Children show powerful impairment imitation, which has associated host neurodevelopmental challenges over time....
Research indicates that human-robot interaction can help children with autism spectrum disorder (ASD). While most early robot-mediated studies were based on free interactions, recent have shown interventions focus the core impairments of ASD such as joint attention deficit tend to produce better outcomes. Joint impairment is one deficits in has an important impact neuropsychological development these children. In this paper, we propose a novel intervention system for overcomes several...
Children with Autism Spectrum Disorder (ASD) often experience difficulty participating in everyday home routines, such as bed time or bath time. This randomized controlled trial examined the efficacy of an interactive, web‐based parenting tutorial for improving children's engagement daily routines (i.e., proximal outcomes) well social communication and stress broad outcomes). Parents children ASD between 18 60 months were randomly assigned to Tutorial group ( n = 52) Control 52). All parents...
Preliminary feasibility and clinical utility research has demonstrated that implementation of a streamlined diagnostic model embedded within primary care (PC) clinics promotes early identification young children with autism spectrum disorder (ASD). Use this results in dramatically reduced waits for consultation, high levels family/provider satisfaction, reductions referrals to overtaxed tertiary centers. The current study extends work by providing data before/after across diverse range PC...
Autism Spectrum Disorder (ASD) affects 1 in 54 children the United States. A core social communication skill negatively impacted by ASD is joint attention (JA), which influences development of language, cognitive, and skills from infancy onward. Although several technology-based JA studies have shown potential, they primarily focus on response to (RJA). The other important component JA, initiation (IJA), has received less a intervention perspective. In this work, we present an immersive...