A5087369453- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Attention Deficit Hyperactivity Disorder
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Receptor Mechanisms and Signaling
- Migraine and Headache Studies
- Computational Drug Discovery Methods
- Sympathectomy and Hyperhidrosis Treatments
- Liver Disease Diagnosis and Treatment
- Cannabis and Cannabinoid Research
- Cholinesterase and Neurodegenerative Diseases
- Ion channel regulation and function
- Drug Transport and Resistance Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Spondyloarthritis Studies and Treatments
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
Galapagos (Belgium)
2018
Takeda (United States)
2014-2015
AbbVie (United States)
2015
Abbott Fund
2008-2011
Abbott (United States)
2008-2011
Novartis (Switzerland)
2009-2011
AEC3 (United Kingdom)
2011
Abbott (United Kingdom)
2005-2009
Stanford University
2009
University of Cincinnati Medical Center
2009
<h3>Background</h3> In healthy individuals, ketamine hydrochloride and amphetamine sulfate produce cognitive, behavioral, subjective effects resembling endogenous psychoses. Studying the comparative interactive of these agents may provide insights into roles glutamate monoamine systems in psychosis cognition. <h3>Objectives</h3> To directly compare to explore their within individuals. <h3>Design</h3> Placebo-controlled, randomized, double-blind psychopharmacologic trial. <h3>Setting...
Abstract Interictal brain energy metabolism and glutamate–glutamine cycling are impaired in epilepsy may contribute to seizure generation. We used the zero‐flow microdialysis method measure extracellular levels of glutamate, glutamine, major substrates glucose lactate epileptogenic nonepileptogenic cortex hippocampus 38 awake epileptic patients during interictal period. Depth electrodes attached probes were identify sites. The had surprisingly high basal glutamate levels, low...
Antagonists of the N-methyl-D-aspartate (NMDA) subclass glutamate receptors and agonists glycine-B coagonist site these have been important tools for characterizing contributions NMDA receptor pathophysiology to a large number neuropsychiatric conditions treating conditions. Among disorders are Alzheimer's disease, chronic pain syndromes, epilepsy, schizophrenia, Parkinson's Huntington's addiction disorders, major depression, anxiety disorders. This review will examine pathophysiological...
Brain levels of glucose and lactate in the extracellular fluid (ECF), which reflects environment to neurons are exposed, have never been studied humans under conditions varying glycemia. The authors used intracerebral microdialysis conscious human subjects undergoing electro-physiologic evaluation for medically intractable epilepsy measured ECF basal during a hyperglycemia–hypoglycemia clamp study. Only measurements from nonepileptogenic areas were included. Under conditions, found metabolic...
Abstract Study objectives were to assess the efficacy, safety, and tolerability of AFQ056 in Parkinson's disease patients with levodopa‐induced dyskinesia. Two randomized, double‐blind, placebo‐controlled, parallel‐group, in‐patient studies for moderate severe dyskinesia (study 1) 2) on stable dopaminergic therapy performed. Patients received 25–150 mg or placebo twice daily 16 days (both studies). 2 included a 4‐day down‐titration. Primary outcomes Lang‐Fahn Activities Daily Living...
Introduction While current standard of care (SOC) for idiopathic pulmonary fibrosis (IPF) slows disease progression, prognosis remains poor. Therefore, an unmet need exists novel, well-tolerated agents that reduce lung function decline and improve quality life. Here we report the design two phase III studies novel IPF therapy, GLPG1690. Methods analysis Two identically designed, III, international, randomised, double-blind, placebo-controlled, parallel-group, multicentre (ISABELA 1 2) were...
The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria).Following screening washout psychotropic medications, 377 randomly assigned a 1:1 ratio to 21 days double-blind treatment ER (N = 192) placebo 185). Daily dosage was initiated at 25 mg/kg, increased 500 mg on day 3, adjusted serum valproate concentrations 85 125 microg/mL. Mania...
Temporal lobe epilepsy (TLE) is associated with smaller hippocampal volume and elevated extracellular (EC) glutamate levels. We investigated the relationship between in refractory TLE patients.We used quantitative MRI volumetrics to measure zero-flow microdialysis interictal glutamate, glutamine, GABA levels epileptogenic hippocampus of 17 patients medication-resistant undergoing intracranial EEG evaluation. The relationships volume, neurochemical levels, relevant clinical factors were...
Dopamine D3 receptors are preferentially localized in the limbic system and midbrain, thus may be involved pathophysiology of neuropsychiatry disorders. [11C](+)-PHNO is first preferential receptor radioligand humans, yet there no blockade studies with a antagonist humans. This study characterized binding by ABT-925, antagonist, healthy male subjects. Sixteen subjects underwent 2–3 positron emission tomography (PET) scans, at baseline following one or two doses ABT-925 ranging from 50 mg to...
Objective.— To evaluate the efficacy, tolerability, and safety of 3 different doses divalproex sodium extended‐release vs placebo in prophylaxis migraine headaches adolescents. Background.— Divalproex has been approved for adults, previous uncontrolled data suggest may be effective preventing children adolescents with acceptable tolerability. Methods.— This was a 12‐week, phase 3, randomized, placebo‐controlled, double‐blind, parallel‐group, multicenter study approximately 300 aged 12 to 17...
MRI relaxometry (R2, R2*) has generally replaced liver biopsy for estimation of iron stores in response to chelation, but there have been no longitudinal studies comparing R2 and R2* techniques. We use concentration (LIC) estimates, transfusional burdens, drug compliance data calculate chelation efficiency (ICE) patients undergoing a Phase II trial SPD602. Fifty-one underwent baseline examination, 39 completed 1 year, 26 2 years. Baseline LICR2 LICR2* estimates were unbiased, had limits...
There is substantial preclinical and clinical evidence to suggest a potential role for the dopamine D₃ receptor in treatment of schizophrenia. ABT-925 selective antagonist with an approximately 100-fold higher vitro affinity versus D₂ receptors. This double-blind, randomized, placebo-controlled, escalating-dose, parallel-group study assessed efficacy safety patients acute exacerbation One hundred fifty-five were over 6-week double-blind period (placebo: n = 48; 50 mg once daily [QD]: 53; 150...