A5103052284- Computational Drug Discovery Methods
- DNA Repair Mechanisms
- Crystal structures of chemical compounds
- Enzyme Structure and Function
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- Cancer, Hypoxia, and Metabolism
- Synthesis and Characterization of Heterocyclic Compounds
- Ubiquitin and proteasome pathways
- PARP inhibition in cancer therapy
- Chemical Thermodynamics and Molecular Structure
- Electric Vehicles and Infrastructure
- Protein Structure and Dynamics
- Microtubule and mitosis dynamics
- Crystallography and molecular interactions
- Infrared Target Detection Methodologies
- 14-3-3 protein interactions
- RNA modifications and cancer
- 2D Materials and Applications
- Plant Genetic and Mutation Studies
- Calibration and Measurement Techniques
- Genetics and Neurodevelopmental Disorders
- Bioinformatics and Genomic Networks
- Redox biology and oxidative stress
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI)
2024
Shenzhen University
2018-2024
North China Electric Power University
2022
Xi'an University of Science and Technology
2022
Shenzhen University Health Science Center
2018-2021
Health Net
2019
Capital Normal University
2017-2018
Liaoning University of Traditional Chinese Medicine
2016
A proper DNA damage response (DDR) is essential to maintain genome integrity and prevent tumorigenesis. double-strand breaks (DSBs) are the most toxic lesion their repair orchestrated by ATM kinase. activated via MRE11-RAD50-NBS1 (MRN) complex along with its autophosphorylation at S1981 acetylation K3106. Activated rapidly phosphorylates a vast number of substrates in local chromatin, providing scaffold for assembly higher-order complexes that can damaged DNA. While reversible ubiquitination...
Abstract Polo-like kinase 1 (PLK1) is a master that regulates cell cycle progression. How its enzymatic activity regulated in response to DNA damage not fully understood. We show PLK1 enriched at double strand breaks (DSBs) within seconds of UV laser irradiation PARP-1-dependent manner and then disperses 10 min PARG-dependent manner. Poly(ADP-)ribose (PAR) chains directly bind vitro inhibit activity. CHK1-mediated phosphorylation S137 prevents binding PAR recruitment DSBs but ensures T210...
The S-phase checkpoint involving CHK1 is essential for fork stability in response to stalling. PARP1 acts as a sensor of replication stress and required activation. However, it unclear how the activity regulated. Here, we found that UFMylation efficient activation by UFMylating at K548 during stress. Inactivation UFL1, E3 enzyme UFMylation, delayed inhibits nascent DNA degradation blockage seen PARP1-deficient cells. An vitro study indicated UFMylated K548, which enhances its catalytic...
Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated dissociates from during mitosis. However, the molecular mechanism detachment unknown. In this report, we found polo-like kinase (PLK1) directly interacted with phosphorylated at Ser-126 . Nocodazole-induced metaphase arrest promoted release chromatin, phosphorylation-defective mutant (S126A) failed to dissociate upon...
Abstract DNA damage response (DDR) is essential for maintaining genome stability and protecting cells from tumorigenesis. Ubiquitin ubiquitin-like modifications play an important role in DDR, signaling to mediating repair. In this report, we found that the E3 ligase ring finger protein 126 (RNF126) was recruited UV laser micro-irradiation-induced stripes a RNF8-dependent manner. RNF126 directly interacted with ubiquitinated another ligase, RNF168. Overexpression of wild type RNF126, but not...
Purpose Green energy as a transportation supply trend is irreversible. In this paper, highway system (HESS) evolution model proposed to provide vehicles and service facilities with clean electricity form new of source-grid-load-storage-charge synergistic highway-PV-WT integrated (HPWIS). This paper aims improve the flexibility index highways increase CO 2 emission reduction highways. Design/methodology/approach To maximize integration potential, energy-generation, storage...
Deriving atmospheric parameters of a large sample stars is vital importance to understand the formation and evolution Milky Way. Photometric surveys, especially those with near-ultraviolet filters, can offer accurate measurements stellar parameters, precision comparable that from low/medium resolution spectroscopy. In this study, we explore capability measuring CSST broad-band photometry (particularly bands), based on synthetic colors derived model spectra. We find optical filter systems...
The stellar atmospheric parameters and physical properties of stars in the Kepler Input Catalog (KIC) are great significance for study exoplanets, activity, asteroseismology. However, despite extensive effort over past decades, accurate spectroscopic estimates these available only about half full KIC catalog. In our work, by training relationships between photometric colors from Gaia DR3, Issac-Newton Survey, LAMOST DR10, APOGEE DR17, we have obtained atmospheric-parameter 195,000 stars,...