A5008311960- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Forensic and Genetic Research
- Cancer Research and Treatments
- Galectins and Cancer Biology
- Pharmacogenetics and Drug Metabolism
- Genetic Associations and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Macrophage Migration Inhibitory Factor
- Cancer-related Molecular Pathways
- Systemic Lupus Erythematosus Research
- Drug Transport and Resistance Mechanisms
- Ocular Oncology and Treatments
- HIV-related health complications and treatments
- Veterinary medicine and infectious diseases
- Transgenic Plants and Applications
- Nonmelanoma Skin Cancer Studies
Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf
2014-2025
Laboratoire de Génétique Cellulaire
2022
Université Oran 1 Ahmed Ben Bella
2020
University Hospital of Oran
2014
Introduction: Ankylosing spondylitis (AS), also known as rheumatic pelvic spondylitis, is considered the primary condition in a group of chronic inflammatory diseases collectively referred to spondyloarthropathies. Objectives: This study aimed explore association between ABCB1 C3435T polymorphism and predisposition ankylosing (AS) Algerian population. The frequency this was compared AS healthy subjects. Methods: A case-control involving 81 patients 98 controls conducted. DNA genotyping done...
Bladder cancer (BC) is a multifactorial disease with poorly understood main cause. In this study, we aimed to evaluate the effect of polymorphisms rs2228611 DNMT1 gene and rs1569686 DNMT3B on susceptibility develop Cancer in Algerian population. A case-control study design was adopted, DNA samples 114 BC patients 123 healthy controls. We found that strongly associated an increased risk development under genetic models: Codominant AG
Introduction: Pharmacogenetic markers, such as the ATP Binding Cassette (ABCB1) and cytochrome P450 (CYP) 3A5 enzymes,play a crucial role in personalized medicine by influencing drug efficacy toxicity based on individuals' or populations'genetic variations.This study aims to investigate genetic polymorphisms of CYP3A5 (rs776746) ABCB1 (rs1045642) West Algerianpopulation compare genotypes allelic distributions with those various ethnic groups. Methods: The involved 472 unrelated healthy...
Summary Ankylosing spondylitis ( AS ) is a complex inflammatory disease that represents major health problem both in Algeria and worldwide. Several lines of evidence support genetic risk factors play role etiology the CTLA 4 gene has attracted considerable attention. In this study, we were interested evaluating HLA ‐B27 frequency exploring sample North African population. The dataset current study composed 81 patients with 123 healthy controls. All samples genotyped by TaqMan ® allelic...
Objectives: The study of polymorphisms genes differentially expressed may lead to the identification putative causal genetic variants in multifactorial diseases such as rheumatoid arthritis (RA). Based on preceding transcriptomic results, we genotyped 10 single nucleotide (SNPs) belonging six (S100A8, RNASE2, PGLYRP1, RUNX3, IL2RB, and LY96) showing highest fold change (> 1.9) when level expression was compared between RA patients controls. These SNPs were then analysed evaluate their role...
Cystic fibrosis (CF) is the most common autosomal recessive disease in Caucasians. Wrongly considered as a European disease, CF found Algeria; but literature data on clinical profile and spectrum of CFTR gene mutations are poor. In this study we investigate twenty-four unrelated Algerian families, with at least one child CF. DNA extracts from blood samples patients parents were screened for using Elucigene CF30 Kit which based PCR/ARMS technique. Only five different identified. On 48 alleles...
The aim of this study was to detect the genetic alterations in Factor 8 gene 26 patients from Western Algeria. We detected presence “intron 22 inversion” with long-range polymerase chain reaction (PCR). Negative for inversion were analyzed 1 using multiplex PCR. Patients who negative both inversions a direct sequencing. Deleterious effects novel mutations on protein assayed bioinformatics tools. Causing identified 85.71% families, including 11 inversion,” and 6 different point (2 nonsense,...
Introduction: Cow's milk proteins allergy (CMPA) pathogenesis involves complex immunological mechanisms with the participation of several cells and molecules involved in food allergy. The association polymorphisms interleukin 4, Forkhead box P3 avian reticuloendotheliosis genes was investigated an infant population CMPA Western Algeria. Materials methods: We obtained DNA clinical data from allergic subjects during active phase a group non-atopic control subjects. Results: Our findings showed...
Abstract Numerous single nucleotide polymorphisms (SNPs) were explored in the Algerian population to evaluate associated ankylosing spondylitis (AS) genetic risk factors, but no study has identified impact of copy number variations (CNVs). The aim was determine whether CNVs CCL3L1 , FCGR3A and FCGR3B genes also with susceptibility AS disease population. data set current is composed 81 patients 119 healthy controls. All samples genotyped by digital droplet PCR (ddPCR). Chi‐square test OR...
The risk to public health conferred by the Omicron variant is still not completely clear, although its numerous gene mutations have raised concerns regarding potential for increased transmissibility and immune escape. In this study, we test compatibility of different primers probes available in commercial kits sold internationally with all sequences SARS-CoV-2 analyzed Algeria until March 2023. Algerian were aligned Muscle tool using Genious software. We also used seven international RT-qPCR...
Ankylosing spondylitis (AS) is chronic inflammatory rheumatism.The Endoplasmic Reticulum Aminopeptidase (ERAP1) gene considered the second genetic factor associated with after HLA-B27.The aim of this study was to assess role ERAP1 rs30187 and rs10050860 polymorphisms in susceptibility AS for first time Algerian population.A total one hundred sixteen controls eighty-one cases were included present study.ERAP1 variants determined by using real-time polymerase chain reaction method.Differences...
Event Abstract Back to Study of association between the polymorphism MICA gene (met 129 val) and Ankylosing Spondylitis in a sample population western Algeria Bouras Noria1*, Benzaoui Ahmed2*, Messal Ibtissem1* Boudjema Abdallah1* 1 University Science Technology Oran USTO, 2 Hospital, Rheumatology Service, (AS) is chronic inflammatory arthritis characterized by predominant axial location (spine), followed joint damage entheses. Although several genes appear be associated with AS, concept...
Event Abstract Back to Study of associations between the specificity HLA-B27 and alleles HLA-DMB with respectively ankylosing spondylitis rheumatoid polyarthritis in a sample Algerian western population Messal Ibtissem1*, Bouras Noria1, BENZAOUI Ahmed2 Boudjema Abdallah1 1 University, Molecular Cellular Genetics, Algeria 2 Teaching Hospital, Department Rheumatology, The (AS) (PR) are autoimmune rheumatic diseases. is characterized by an enthesitis axial skeleton (rachis sacroiliac) leading...