A5007457221- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Balance, Gait, and Falls Prevention
- Health disparities and outcomes
- Cardiovascular Syncope and Autonomic Disorders
- Alzheimer's disease research and treatments
- Heart Rate Variability and Autonomic Control
- Chronic Disease Management Strategies
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Alcohol Consumption and Health Effects
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- Substance Abuse Treatment and Outcomes
- Nutritional Studies and Diet
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Clinical Nutrition and Gastroenterology
- Osteoarthritis Treatment and Mechanisms
- Health and Wellbeing Research
- Folate and B Vitamins Research
- Geriatric Care and Nursing Homes
- Health and Well-being Studies
- Body Composition Measurement Techniques
University of Malaya
2016-2025
University Malaya Medical Centre
2010-2025
Tân Tạo University
2020
National University of Malaysia
2013-2019
Ministry of Education
2019
University Kebangsaan Malaysia Medical Centre
2019
Ministry of Health
2019
St. James's Hospital
1980-2011
University of Kuala Lumpur
2011
Trinity College Dublin
2010
While several studies have found a link between impaired cognition and social isolation, few examined the relationship loneliness. Loneliness has been thought to increase risk of development Alzheimer's dementia.The aims this study were explore loneliness determine whether specific cognitive domains are associated with loneliness.Cross-sectional community-based study.This included 466 community-dwelling subjects mean age 75.45 (SD 6.06) years, which 208(44%) males.Loneliness was...
ABSTRACT Background: Life satisfaction is a subjective expression of well-being and successful aging. Subjective major determinant health outcomes in older people. The aim this study was to determine which factors predicted people living the community as measured by their with life. Methods: relationship between life satisfaction, Satisfaction Index (LSI-A) physical, cognitive demographic variables examined 466 using stepwise regression model Results: Depression, loneliness, neuroticism,...
Hand strength is a good indicator of physical fitness and frailty among the elderly. However, there are no published hand references for Malaysians aged > 65 years. This study aimed to establish normative data grip (HGS) key pinch (KPS) ≥ 60 years, explore relationship between ability.Healthy participants years with neurological conditions were recruited from rural urban locations in Malaysia. HGS KPS measured using dynamometers. Basic demographic data, anthropometric measures, modified...
Multiethnic Malaysia provides a unique case study of divergence in population aging different sociocultural subgroups within country. represents 3 major ethnicities Asia—the Malay, Chinese, and Indian. The ethnic groups are at stages aging, as they have undergone demographic transition pace amidst rapid social economic changes. Between 1991 2010, the Malaysian aged 60 over has more than doubled from about 1 million to 2.2 million, this is projected rise 7 or 17.6% 40 by 2040. In index ranged...
Cognitive frailty (CF) is a major precursor to dementia, and multidomain interventions have the potential delay, prevent or reverse its early onset. However, successful translation sustainability of such in real-life settings remain uncertain. In this study, we aimed explore insights older adults with CF their caregivers regarding impact participation AGELESS intervention. This qualitative study was conducted following completion Semi-structured interviews covering domains as perceptions,...
Background: Cognitive frailty (CF) is identified as one of the main precursors dementia. Multidomain intervention has been found to delay or prevent onset CF. Objective: The aim our present study determine effectiveness a comprehensive, multidomain on CF; evaluate its cost and factors influencing adherence toward this intensive intervention. Methods: A total 1,000 community dwelling older adults, aged 60 years above will be screened for This randomized controlled trial involves recruitment...
Aim To determine the dependency scores, long‐term mortality and factors associated with in older people presenting to emergency department ( ED ) a fall. Methods Information on sociodemographics, using B arthel index fall characteristics were collected from consecutive patients attending over 6‐month period. Barthel score was reassessed at 12 months. Ten‐year data obtained through N ational R egistry D epartment. Results A total of 198 participants, mean age (standard deviation) 76.2 years...
Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is a major concern in the global healthcare system. However, data from Asian regions dealing with singularity of this infection older persons lacking. We aimed to identify differences clinical characteristics and outcomes MRSA between adults aged 18-64 ≥ 65 years.A retrospective study cohort was conducted at University Malaya Medical Centre (UMMC) on cases 2012 2016. Patient demographic were collected for risk factors analyses.New...
The incidence of Alzheimer's disease, particularly in developing countries, is expected to increase exponentially as the population ages. Continuing research this area essential order better understand disease and develop strategies for treatment prevention. Genome-wide association studies have identified several loci genetic risk factors AD aside from apolipoprotein E such bridging integrator (BIN1), clusterin (CLU), ATP-binding cassette sub-family A member 7 (ABCA7), complement receptor 1...
Loneliness has been associated with poor physical health and a link suggested between the presence of loneliness, cardiovascular inflammatory markers.To investigate association vascular disease biomarkers loneliness in community-dwelling non-demented elderly population.cross-sectional community based assessment.466 subjects mean age 75.45 (SD, 6.06) years. 208 (44.6%) were male.Higher levels HbA1c, but not other independently being lonely.Loneliness was raised HbA1c dwelling population. The...
Falls represent major health issues within the older population. In low/middle-income Asian countries, falls in adults remain an area which has yet to be studied detail. Using data from Malaysian Elders Longitudinal Research (MELoR), we have estimated prevalence of among persons urban population, and performed ethnic comparisons falls.Cross-sectional analysis was carried out using first wave MELoR is a longitudinal study.Urban community dwellers middle-income South East country.1565...
A barrier to gastrostomy feeding exists among Asian clinicians and caregivers due negative perceptions regarding complications. We compared clinical nutrition outcomes in older dysphagic patients with nasogastric (NG) or tube using a pragmatic study design.The choice of enteral access was determined by managing patients/caregivers. Comparisons methods were made during 4-month period, adjusting statistically for inherent confounders.A total 102 participants (NG: n = 52, gastrostomy: 50)...
Abstract Aim Cytokines released from chronically‐activated microglia could result in neuroinflammation. An accurate profile of the relationship between cytokines and Alzheimer's disease (AD) pathogenesis, as well patterns these inflammatory mediators AD patients lead to identification peripheral markers for disease. The present study was undertaken identify pro‐ anti‐inflammatory associated with Malaysian population. Methods Further informed consent 39 healthy subjects probable patients, 8.5...