A5006446557- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
Duke University
2022
Glucagon and insulin are commonly believed to have counteracting effects on blood glucose levels. However, recent studies demonstrated that glucagon has a physiologic role activate β cells enhance secretion. To date, the actions of been studied mostly in fasting or hypoglycemic states, yet it is clear mixed-nutrient meals elicit secretion both insulin, suggesting also contributes regulation postprandial state. We hypothesized elevated glycemia seen fed state would allow stimulate reduce...
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) augments insulin secretion through its receptor expressed on islet β-cells. GIP also acts adipose tissue; yet paradoxically, both enhanced and reduced (GIPR) signaling reduce tissue mass attenuate weight gain in response to nutrient excess. Moreover, the precise cellular localization of GIPR expression within white (WAT) remains uncertain. We used mouse genetics target Gipr adipocytes. Surprisingly, targeting Cre...
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) augments insulin secretion through its receptor expressed on islet b-cells. GIP also acts adipose tissue, yet paradoxically, both enhanced and reduced (GIPR) signaling reduce tissue mass attenuate weight gain in response to nutrient excess. Moreover, the precise cellular localization of GIPR expression within white (WAT) remains uncertain. Here, we used mouse genetics target <i>Gipr </i>expression adipocytes....
The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) augments insulin secretion through its receptor expressed on islet b-cells. GIP also acts adipose tissue, yet paradoxically, both enhanced and reduced (GIPR) signaling reduce tissue mass attenuate weight gain in response to nutrient excess. Moreover, the precise cellular localization of GIPR expression within white (WAT) remains uncertain. Here, we used mouse genetics target <i>Gipr </i>expression adipocytes....