A5038699253- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- Frailty in Older Adults
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Health Systems, Economic Evaluations, Quality of Life
- Anorectal Disease Treatments and Outcomes
- Intravenous Infusion Technology and Safety
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Esophageal and GI Pathology
- Hip and Femur Fractures
- Hernia repair and management
- Clinical Nutrition and Gastroenterology
- Immune Cell Function and Interaction
- Anesthesia and Sedative Agents
Azienda Ospedaliera San Gerardo
2022
Ospedale Policlinico San Martino
2010-2021
University of Milano-Bicocca
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2017
Clinica Luganese Moncucco
2016
University of Genoa
1989-1991
Amino-bis-phosphonates (N-BPs) such as zoledronate (Zol) have been used in anticancer clinical trials due to their ability upregulate pyrophosphate accumulation promoting antitumor Vγ9Vδ2 T cells. The butyrophilin 3A (BTN3A, CD277) family, mainly the BTN3A1 isoform, has emerged an important structure contributing cells stimulation. It demonstrated that B30.2 domain of can bind phosphoantigens (PAg) and drive activation through conformational changes extracellular domains. Moreover, binding...
Mechanical bowel preparation is routinely done before colon and rectal surgery, aimed at reducing the risk of postoperative infectious complications. The aim study was to assess whether elective surgery can be safely performed without preoperative mechanical preparation. Patients undergoing resections with primary anastomosis were prospectively randomized into two groups. Group A had polyethylene glycol group B their followed up for 30 days wound, anastomotic, intra-abdominal Two hundred...
Mesenchymal stromal cells (MSC) present in the tumor microenvironment [usually named tumor-associated fibroblasts (TAF)] can exert immunosuppressive effects on T and natural killer (NK) lymphocytes, favoring immune escape. We have analyzed this mechanism colorectal carcinoma (CRC) found that co-culture of NK with TAF prevent IL-2-mediated NKG2D upregulation. This leads to impairment NKG2D-mediated recognition CRC cells, sparing cell activation through DNAM1 or FcγRIIIA (CD16). In situ,...
Comprehensive Geriatric Assessment (CGA), the gold standard for detecting frailty in elderly cancer patients, is time-consuming and hard to apply routine clinical practice. Here we compared performance of two screening tools frailty, G8 SAOP2 their accuracy identifying vulnerable patients.We tested 282 patients aged 65 or older with a diagnosis solid candidate undergo surgical, medical and/or radiotherapy treatment. CGA, including functional cognitive status, depression, nutrition,...
Standard treatment for locally advanced rectal adenocarcinoma (LARC) includes a combination of chemotherapy with pyrimidine analogues, such as capecitabine, and radiation therapy, followed by surgery. Currently no clinically useful genomic predictors benefit from neoadjuvant chemoradiotherapy (nCRT) exist LARC. In this study we assessed the expression 8,127 long noncoding RNAs (lncRNAs), poorly studied in LARC, to infer their ability classifying patients' pathological complete response...
Abstract Background Urachal carcinoma is an uncommon neoplasm associated with poor prognosis. Case presentation A 45-year-old man was admitted complaints of abdominal pain and pollakisuria. soft mass palpable under his navel. TC-scan revealed a 11 × 6 cm tumor, which composed cystic lesion arising from the urachus solid component at urinary bladder dome. The tumor removed surgically. Histological examination detected poor-differentiated adenocarcinoma, had invaded bladder. patient has been...
Adequate lymph nodes resection in rectal cancer is important for staging and local control. This retrospective analysis single center study evaluated the effect of neoadjuvant chemoradiation on number carcinoma, considering some clinicopathological parameters. A total 111 patients undergone mesorectal excision adenocarcinoma from July 2005 to May 2012 our were included. No patient underwent any prior pelvic surgery or radiotherapy. Chemoradiotherapy was indicated with stage II III before...
Over the past few years, next-generation sequencing (NGS) has become reliable and cost-effective, its use in clinical practice a reality. A relevant role for NGS is prediction of response to anti-EGFR agents metastatic colorectal cancer (mCRC), where multiple exons from KRAS, NRAS, BRAF must be sequenced simultaneously.
Observational/retrospective studies indicate that prostaglandin-endoperoxide synthase-2 (PTGS2) inhibitors could positively affect colorectal cancer (CRC) patients’ survival after diagnosis. To obtain an acceptable cost/benefit balance, the inclusion of PTGS2 in adjuvant setting needs a selective criterion. We quantified 72 kDa, CRC-associated, glycosylated form 100 frozen CRC specimens and evaluated localization by IHC same tumors, scoring tumor epithelial-derived stroma-derived fractions....
Postoperative delirium (POD) is more frequent in elderly patients undergoing major cancer surgery. The interplay between individual clinical vulnerability and a series of perioperative factors seems to play relevant role. Surgery the first-line treatment option for cancer, fast-track surgery (FTS) has been documented decrease postoperative complications. study sought assess, after comprehensive geriatric assessment (CGA) frailty stratification (Rockwood 40 items index), which parameters were...
Delirium and sarcopenia are common, although underdiagnosed, geriatric syndromes. Several pathological mechanisms can link delirium low skeletal muscle mass, but few studies have investigated their association. We aimed to investigate (1) the association between mass (2) possible role of calf circumference in finding cases with delirium.The analyses were conducted employing cross-sectional "Delirium Day" initiative, on patient 65 years older admitted acute hospital medical wards, emergency...
Neoadjuvant chemoradiotherapy (neoCRT) is recommended for locally advanced rectal cancer (RC), however, this often makes lymph node (LN) search trying. The aim of study was to evaluate, in a large retrospective, monocentric, series post-neoCRT-RC patients, the importance LN number, ratio and surface area predicting metastases, overall survival (OS) disease free (DFS).104 patients with RC underwent total mesorectal excision, after standard neoCRT. All resected specimens were examined...
Hepatic encephalophathy (HE) is a neuropsychiatric syndrome with prevalence in the cirrhotic population ranging from 20 to 80%. HE cause of inappropriate hospitalization, caregiver burdening and increased social costs. There need create dedicated care pathways better manage patients support family caregivers. The data used for preparation this diagnostic therapeutic assistance path (DTAP) are based on detailed analysis scientific literature published before June 30, 2022 (PubMed, Web...