Ashish Dahal
A5003981659- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Web and Library Services
- Cancer Cells and Metastasis
- Immune cells in cancer
- Music Therapy and Health
- Family and Patient Care in Intensive Care Units
- Meningioma and schwannoma management
- Nanoplatforms for cancer theranostics
- Pediatric Pain Management Techniques
- Social Media in Health Education
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Surgical Oncology
Harvard University
2021-2025
Massachusetts General Hospital
2021-2023
Center for Cancer Research
2023
Somerville Hospital
2021
Melanoma-derived brain metastases (MBM) represent an unmet clinical need because central nervous system progression is frequently end stage of the disease. Immune checkpoint inhibitors (ICI) provide a opportunity against MBM; however, MBM tumor microenvironment (TME) has not been fully elucidated in context ICI. To dissect unique elements TME and correlates response to ICI, we collected 32 fresh performed single-cell RNA sequencing T-cell receptor clonotyping on T cells from matched blood...
Abstract Purpose: Brain metastases are associated with high morbidity and often resistant to immune checkpoint inhibitors. We evaluated whether CDK4/6 inhibitor (CDKi) abemaciclib can sensitize intracranial tumors programmed cell death protein 1 (PD-1) inhibition in mouse models of melanoma breast cancer brain metastasis. Experimental Design: Treatment response was vivo using immunocompetent metastasis bearing concurrent extracranial tumors. effect on tumor–immune microenvironments (TIME)...
Unlike pediatric care that often benefits from child-life services, adult hospitals rarely offer structured engagement activities for postsurgical patients. To address this, we conducted a prospective, randomized survey-based study to evaluate the impact of creative on inpatient experiences. Patients undergoing surgery between January and September 2023 were randomly assigned either standard postoperative course or one received an entertainment packet. Both cohorts completed survey about...
<div>AbstractPurpose:<p>Brain metastases are associated with high morbidity and often resistant to immune checkpoint inhibitors. We evaluated whether CDK4/6 inhibitor (CDKi) abemaciclib can sensitize intracranial tumors programmed cell death protein 1 (PD-1) inhibition in mouse models of melanoma breast cancer brain metastasis.</p>Experimental Design:<p>Treatment response was <i>in vivo</i> using immunocompetent metastasis bearing concurrent extracranial...
<p>Figures S1-13, Tables S1-2</p>
<div>AbstractPurpose:<p>Brain metastases are associated with high morbidity and often resistant to immune checkpoint inhibitors. We evaluated whether CDK4/6 inhibitor (CDKi) abemaciclib can sensitize intracranial tumors programmed cell death protein 1 (PD-1) inhibition in mouse models of melanoma breast cancer brain metastasis.</p>Experimental Design:<p>Treatment response was <i>in vivo</i> using immunocompetent metastasis bearing concurrent extracranial...
<p>Figures S1-13, Tables S1-2</p>
Abstract Metastases are the most common malignancy of adult central nervous system and becoming an increasingly troubling problem in oncology largely due to lack successful therapeutic options. The limited selection treatments is a result currently poor understanding biological mechanisms metastatic development, which turn difficult achieve because preclinical models that can accurately represent clinical progression metastasis. Described this article vitro vivo model systems used enhance...
<div>Abstract<p>Melanoma-derived brain metastases (MBM) represent an unmet clinical need because central nervous system progression is frequently end stage of the disease. Immune checkpoint inhibitors (ICI) provide a opportunity against MBM; however, MBM tumor microenvironment (TME) has not been fully elucidated in context ICI. To dissect unique elements TME and correlates response to ICI, we collected 32 fresh performed single-cell RNA sequencing T-cell receptor clonotyping on T...
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Figure from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
<div>Abstract<p>Melanoma-derived brain metastases (MBM) represent an unmet clinical need because central nervous system progression is frequently end stage of the disease. Immune checkpoint inhibitors (ICI) provide a opportunity against MBM; however, MBM tumor microenvironment (TME) has not been fully elucidated in context ICI. To dissect unique elements TME and correlates response to ICI, we collected 32 fresh performed single-cell RNA sequencing T-cell receptor clonotyping on T...
Supplementary Figure from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition
Supplementary Data from Microenvironmental Landscape of Human Melanoma Brain Metastases in Response to Immune Checkpoint Inhibition