A5042553081- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- COVID-19 and Mental Health
- Viral Infections and Vectors
- Leptospirosis research and findings
- Digital Mental Health Interventions
- Toxin Mechanisms and Immunotoxins
- Eosinophilic Disorders and Syndromes
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- COVID-19 Clinical Research Studies
- Bone fractures and treatments
- Vitamin C and Antioxidants Research
- Leprosy Research and Treatment
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Dermatological and COVID-19 studies
- Eosinophilic Esophagitis
- Telemedicine and Telehealth Implementation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Studies on Chitinases and Chitosanases
- COVID-19 diagnosis using AI
- Social Media in Health Education
University of Iowa
2015-2024
Eastern Virginia Medical School
2021-2024
Sentara Norfolk General Hospital
2024
Sentara Virginia Beach General Hospital
2022-2024
Old Dominion University
2024
Sentara Heart Hospital
2022-2023
Quality Research
2022
Abstract During visceral leishmaniasis (VL), Th1-based inflammation is induced to control intracellular parasites. Inflammation-based pathology was shown be dampened by IL-10 and eventual programmed death 1–mediated T cell exhaustion. Cell type(s) responsible for the initiation of cell–produced during VL are unknown. CD19+, CD5−, CD1d−, IgDhi regulatory B cells from healthy controls produced in absence infection or stimulation, contrast IgDlo/neg cells. may have a de novo versus program. The...
Visceral leishmaniasis (VL) is a vector borne zoonotic disease endemic in humans and dogs Brazil. Due to the increased risk of human infection secondary presence infected dogs, public health measures Brazil mandate testing culling dogs. Despite this important relationship between canine infection, little known about what makes dog reservoir progress clinical illness, significantly tied infectiousness sand flies. Dogs areas are exposed many tick-borne pathogens, which likely alter immune...
Leishmania infantum causes human Visceral Leishmaniasis and Leishmaniosis (CanL) in reservoir host, dogs. As infection progresses to disease both humans dogs there is a shift from controlling, Type 1, immunity regulatory, exhausted, T cell phenotype. In endemic areas, association between tickborne coinfections (TBC) diagnosis and/or clinical severity has been demonstrated. To identify immune factors correlating with progression, we prospectively evaluated cohort of L. infected 2019-2022. The...
Abstract Background Both incidence and geographical range of tick-borne disease has increased across the USA. Similar to people, dogs are hosts for Anaplasma spp., Babesia Ehrlichia spp. Borrelia burgdorferi. Dogs also share our homes beds, making them both a sentinel ticks in backyards but increasing exposure ticks. Measures better track, prevent, and/or treat diseases companion animals can lead control prevention human disease. This study identifies demographic co-infection risk factors...
Background Dogs are the primary reservoir for human visceral leishmaniasis due to Leishmania infantum . Phlebotomine sand flies maintain zoonotic transmission of parasites between dogs and humans. A subset is infected transplacentally during gestation, but at what stage clinical spectrum vertically contribute fly pool unknown. Methodology/Principal findings We examined infectiousness with L from multiple states vector Lutzomyia longipalpis using xenodiagnosis found that were infectious...
The COVID-19 pandemic has affected people's lives beyond severe and long-term physical health symptoms. Social distancing quarantine have led to adverse mental outcomes. COVID-19-induced economic setbacks also likely exacerbated the psychological distress affecting broader aspects of well-being. Remote digital studies can provide information about pandemic's socioeconomic, mental, impact. COVIDsmart was a collaborative effort deploy complex research study understand impact on diverse...
Visceral Leishmaniasis is a deadly disease caused by Leishmania infantum, endemic in more than 98 countries across the globe. Although most common means of transmission via sand fly vector, there growing evidence that vertical may be critical for maintaining L. infantum infection within reservoir, canine, population. Vertical also an important cause infant morbidity and mortality particularly sub-Saharan Africa. While visceralizing species has been reported around globe, risk factors...
Abstract Background The effects of vitamin C on clinical outcomes in critically ill patients remain controversial due to inconclusive studies. This retrospective observational cohort study evaluated the therapy acute kidney injury (AKI) and mortality among septic patients. Methods Electronic medical records 1390 from an academic hospital who were categorized as Treatment (received at least one dose 1.5 g IV C, n = 212) or Comparison no, less than 1178) reviewed. Propensity score matching was...
In Leishmania infantum-endemic countries, controlling infection within dogs, the domestic reservoir, is critical to public health. There a need for safe vaccines that prevent canine progression with disease and transmission others. Protective vaccination against requires mounting strong, inflammatory, Type 1 response. Three commercially available on global veterinary market use saponin or inflammatory antigen components (Letifend) as strong pro-inflammatory adjuvant. very little information...
This study examined the development of new or changes in donor specific antibodies (DSA) mean-fluorescence intensity (MFI) after SARS-CoV-2 vaccination 100 kidney and 50 heart transplant recipients. The was performed when Center for Disease Control Prevention (CDC) recommended two doses Pfizer/BioNTech [BNT162b2] Moderna [mRNA-1273 SARS-CoV-2] vaccine 1 dose Johnson & Johnson/Janssen [Ad26.COV2·S] vaccines full A novel assay bead-based platform detecting against 4 domains spike protein to...
Certain professionals have more exposure to animals and therefore an increased risk of zoonoses. Professional hunting dog caretakers work with upwards 50 dogs are exposed zoonoses through multiple potentially infectious canine secretions or excretions, as well the ticks that carry. Dog reported having found embedded on their bodies 5.83 times than environment-only controls. Zoonotic Lyme disease, first in United States for morbidity due a vector-borne infection, has dramatically expanded its...
Visceral leishmaniasis is a deadly infectious disease and one of the world's major neglected health problems. Because symptoms infection are similar to other endemic diseases, accurate diagnosis crucial for appropriate treatment. Definitive using splenic or bone marrow aspirates highly invasive, so, serological assays preferred, including direct agglutination test (DAT) rK39 strip test. These tests, however, either difficult perform in field lack specificity some regions (rK39), making...
Leishmaniasis, a neglected tropical disease, currently infects approximately 12 million people worldwide with 1 to 2 new cases each year in predominately underdeveloped countries. The treatment of the disease is severely due ability Leishmania pathogen evade and abate immune responses. In an effort develop anti-leishmaniasis vaccines adjuvants, novel carbohydrate-based probes were made study mechanisms modulation. this study, bioerodible polyanhydride microparticle was designed conjugated...