A5101772849- Congenital heart defects research
- Environmental Science and Technology
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Physics and Engineering Research Articles
- Acute Myeloid Leukemia Research
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Prenatal Screening and Diagnostics
- Cytomegalovirus and herpesvirus research
- Hematopoietic Stem Cell Transplantation
- Pluripotent Stem Cells Research
University Medical Center Freiburg
2025
University of Freiburg
2017-2023
Cell-fate decisions and pluripotency are dependent on networks of key transcriptional regulators. Recent reports demonstrated additional functions pluripotency-associated factors during early lineage commitment. The T-box transcription factor TBX3 has been implicated in regulating embryonic stem cell self-renewal cardiogenesis. Here, we show that is dynamically expressed specification the mesendoderm lineages differentiating cells (ESCs) vitro developing mouse Xenopus embryos vivo. Forced...
3119 Background: BRAF is a frequently mutated gene in cancer, with most mutations (mut) at the activating hotspot V600 codon. Recently, kinase-inactive class III mut emerged as oncogenic driver and potential therapeutic target, they lead to paradoxical cross-activation of RAF1- RAS-dependent downstream signaling. Here we report Phase I toxicity results combinatory inhibition RAF kinases by sorafenib (S), multi-kinase inhibitor (e.g. RAF1, BRAF, c-KIT, FLT-3) MEK/ERK signaling trametinib (T)...
Summary Acute myeloid leukaemia (AML) relapse after allogeneic haematopoietic cell transplantation (allo‐HCT) is often driven by immune‐related mechanisms and associated with poor prognosis. Immune checkpoint inhibitors combined hypomethylating agents (HMA) may restore or enhance the graft‐versus‐leukaemia effect. Still, data about using this combination regimen allo‐HCT are limited. We conducted a prospective, phase II, open‐label, single‐arm study in which we treated patients...
Trophoblast stem cells (TSCs) represent the multipotent progenitors that give rise to different of embryonic portion placenta. Here, we analysed expression key TSC transcription factors Cdx2 , Eomes and Elf5 in early developing placenta mouse embryos cultured TSCs reveal surprising heterogeneity protein levels. We persistence find remain chorionic hinge until E9.5 are lost shortly afterwards. To define transcriptional signature bona fide TSCs, used inducible gain- loss-of-function alleles or...
The T-box transcription factor Eomes (also known as Tbr2) shows short-lived expression in various localized domains of the embryo, including epiblast cells during gastrulation and intermediate progenitor cerebral cortex. In these tissues fulfills crucial roles for lineage specification progenitors. To directly observe Eomes-dependent cell lineages living we generated a novel dual-fluorescence reporter allele that expresses membrane-bound tdTomato protein investigation morphology nuclear GFP...