A subset of idiopathic pulmonary fibrosis cases has a familial component. Telomeric mutations, such as those in the Regulator Telomere Elongation Helicase 1 (RTEL1) gene, have been associated with lung and minority dyskeratosis congenita (DC) cases. We present case male his 50s fibrosis, cryptogenic hepatic cirrhosis, chronic anaemia thrombocytopenia, lacy skin hyperpigmentation, dystrophic nails canities. Family history included two brothers. Genetic testing identified RTEL1 mutation...

We present LimberJack.jl, a fully auto-differentiable code for cosmological analyses of 2 point auto- and cross-correlation measurements from galaxy clustering, CMB lensing weak data written in Julia. Using Julia's auto-differentiation ecosystem, LimberJack.jl can obtain gradients its outputs up to an order magnitude faster than traditional finite difference methods. This makes greatly synergistic with gradient-based sampling methods, such as Hamiltonian Monte Carlo, capable efficiently...

Venlafaxine is a serotonin-norepinephrine reuptake inhibitor used as an antidepressant. Interindividual variability and herb-drug interactions can lead to drug-induced toxicity. We report the case of 35-year-old female patient diagnosed with synchronous pneumonitis acute cardiomyopathy attributed venlafaxine. The sought medical attention due dyspnea dry cough that started three months after initiating treatment venlafaxine for depression. was concomitantly taking Centella asiatica Fucus...

People with interstitial lung disease (ILD) present low levels of physical activity (PA) and spend most their time at home, especially in advanced stages the disease. The Lifestyle Integrated Functional Exercise for people ILD (iLiFE) embedding PA patients' daily routines was developed implemented.This study aimed to explore feasibility iLiFE.A pre/post mixed-methods conducted. Feasibility iLiFE determined by participant recruitment/retention, adherence, outcome measures adverse events....

Despite the fact that there are a great number of established etiologies for pleural effusion, grounds believing also causes from unusual pathophysiological mechanisms, seen in certain clinical contexts and potential iatrogenic interventions. Urinothorax is such rare type effusion as fewer than 70 cases reported worldwide. A patient with persistent left was admitted to Urology ward lithiasic obstructive uropathy hydronephrosis. percutaneous nephrostomy performed. The unclassified at initial...

Nitrofurantoin-induced diffuse lung toxicity is well documented in the literature but often misdiagnosed. We describe an 82-year-old female medicated with nitrofurantoin for previous 2 years who was admitted dyspnoea, dry cough and fatigue 4 months. She febrile tachypnoeic she presented bilateral basal crackles, hypoxaemic respiratory failure slightly elevated C-reactive protein levels. A chest radiograph showed air-space consolidation interstitial infiltrates high-resolution computed...

Interstitial lung diseases (ILDs) comprise a group of multiple entities sharing some clinical, functional, and radiological similarities. In many countries primary care setting has been devoid pre- post-graduate educational interventions focused on basic knowledge ILD. This, along with usual nonspecificity symptoms at presentation, may contribute to diagnostic delay in this disease setting.We designed study questionnaire assess the level awareness management aspects core ILDs - idiopathic...


 Background. Hypersensitivity pneumonitis is a syndrome caused by sensitisation to inhaled antigens that leads an abnormal immune response in the airways and lung parenchyma. Some patients previously diagnosed with certain types of fibrotic interstitial diseases, including HP, are susceptible develop progressive fibrosing phenotype, despite initial state- of-the-art management.
 Objectives. To characterise cohort multidisciplinary diagnosis chronic f-HP, who were followed up ILD...

As the statistical power of imaging surveys grows, it is crucial to account for all systematic uncertainties. This normally done by constructing a model these uncertainties and then marginalizing over additional parameters. The resulting high dimensionality total parameter spaces makes inferring cosmological parameters significantly more costly using traditional Monte-Carlo sampling methods. A particularly relevant example redshift distribution, $p(z)$, source samples, which may require tens...

Case report of a male patient with five-decade follow-up history in tertiary care hospital distinguished for malabsorption syndrome, failure-to-thrive, meningitis and recurrent bacterial, fungal mycobacterial pulmonary infections. Additionally, he developed epidermodysplasia verruciformis, several situ spinocellular carcinomas an uncharacteristic parenchymal lung disease. Surgical biopsy suggested alveolar proteinosis fibrotic change. Retrospectively, severe monocytopenia had been overlooked...

The Chester Step Test (CST) is a simple and inexpensive field test, which requires minimal physical space to assess exercise capacity. Such characteristics make the CST suitable be used in different settings, however, its measurement properties patients with interstitial lung diseases (ILD) are unknown.

We use numerical simulations of scalar field dark matter evolving on a moving black hole background to confirm the regime validity (semi-)analytic expressions derived from first principles for both dynamical friction and momentum accretion in relativistic regime. cover small large clouds (relative de Broglie wavelength scalars), light heavy particle masses BH size). In case cloud, effect is non-negligible contribution total force hole, even masses. that this transitions between two regimes...

We analyse Starobinsky inflation in the presence of Brout Englert Higgs (BEH) boson with a non-minimal coupling to Ricci scalar, $R$. The latter induces massive scaleron associated $R^2$ term BEH and this leads radiative correction mass that must be fine tuned keep scalar light. For case driven requires high level tuning order 1 part $10^{8}$; for it is very much greater. consider scale invariant extension $R^2$/Higgs model find but not required significantly reduced one $10^{3-4}$. vacuum...