A5068178483- Multiple Sclerosis Research Studies
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Neurology and Historical Studies
- Retinal and Optic Conditions
- Dermatological and Skeletal Disorders
- Ocular Diseases and Behçet’s Syndrome
- Autoimmune Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Peripheral Nerve Disorders
- Neurological disorders and treatments
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Neurological Complications and Syndromes
- Myasthenia Gravis and Thymoma
- Venous Thromboembolism Diagnosis and Management
- Polyomavirus and related diseases
- Parkinson's Disease and Spinal Disorders
- Orthopedic Surgery and Rehabilitation
- Systemic Lupus Erythematosus Research
- Amyotrophic Lateral Sclerosis Research
- COVID-19 and healthcare impacts
- Glaucoma and retinal disorders
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
The University of Texas at Austin
2018-2024
Multiple Sclerosis Center of Atlanta
2022
Wayne State University
2018-2020
National Multiple Sclerosis Society
2018-2020
Stanford University
2020
University of California, San Francisco
2018-2020
Johns Hopkins University
2020
Grand Canyon University
2020
Seton Medical Center
2020
Emory University
2020
<h3>Importance</h3> A neurophysiologic signature of the melanopsin-mediated persistent constriction phase pupillary light reflex may represent a surrogate biomarker for integrity retinohypothalamic tract, with potential utility investigating alterations in homeostatic mechanisms associated brain disorders and implications identifying new treatments. <h3>Objective</h3> To characterize abnormalities retinal architecture patients multiple sclerosis (MS) corresponding sustained response....
Dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) cause diverse and largely distinct channelopathies, including inherited forms of neuromuscular disease, skeletal dysplasias arthropathy. Pathogenic gain function toxicity that can be rescued by small molecule antagonists cellular animal models, suggesting antagonism could therapeutic for patients. Numerous variants have been detected with targeted whole exome/genome sequencing, but vast...
To determine whether the punctuated administration of low-dose rituximab, temporally linked to B-cell hyperrepopulation (defined when return CD19+ B cells approximates 40%-50% baseline levels as measured before alemtuzumab treatment inception), can mitigate alemtuzumab-associated secondary autoimmunity.In this hypothesis-driven pilot study, 10 patients received rituximab (50-150 mg/m2), a chimeric anti-CD20 monoclonal antibody, after either their first or second cycles alemtuzumab. These...
Excessive daytime sleepiness (EDS) in multiple sclerosis (MS) can be a significant source of disability. Despite this, its prevalence as patient-reported outcome this condition has not been well established, and causes are understood.We prospectively assessed EDS part an observational study for patients referred diagnostic neuro-ophthalmological testing. was evaluated by the Epworth Sleepiness Scale (ESS), visual data were also collected research protocol. Analysis with patient performed...
Hypercalcemia from tumors has been associated with Posterior Reversible Encephalopathy Syndrome (PRES) but the mechanism remains unclear. In this article, we describe a case of PRES caused by hypercalcemia lymphoma. We summarize available scientific evidence linking to failure cerebral autoregulation and potentially PRES. A major link is hypomagnesemia induced hypercalcemia. While concept requires further clinical testing validation, it clinically significant for management PRES, even when...
A 38-year-old woman with MS receiving natalizumab presented to the neurology clinic complaint of a new neurologic symptom. ### Clinical course The patient had 6-year history clinically stable MS, albeit exhibiting radiographic progression despite strict adherence daily
A 79-year-old man presented after a week of pleuritic-type chest pain, dyspnea and swollen, painful left arm. His past medical history included benign prostatic hypertrophy, vitiligo, hearing loss combat wound to the experienced 58 years earlier, with bullet in situ adjacent
The patient is a right-handed White woman with relapsing-remitting MS diagnosed subsequent to left acute optic neuritis (AON). She described previous transient episode of severe, electrical, and paroxysmal facial pain consistent trigeminal neuralgia. Initial MRI demonstrated supratentorial
A gentleman in his late 40s developed a "pins and needles" sensation numbness left hand that was exacerbated by leaning on arm or hyperextending neck. The over few weeks. Over the next 2 months, spread proximally arm, then to right patches bilateral upper chest posterior thighs. He denied pain, weakness, fatigue, cognitive changes, vision dysarthria, dysphagia changes bladder bowel function. review of systems otherwise negative normal. Past medical history notable for hyperlipidemia, treated...
A 17-year-old man was brought to the emergency department with several weeks of irritability, insomnia, and depression, followed by 1 week nonsensical speech visual, nonthreatening hallucinations. His medical history included depression Sydenham chorea diagnosed when he aged 12 years positive ASO titer anti-DNAse B antibodies. The National Multiple Sclerosis Society Case Conference Proceedings are both a live educational Webinar, in conjunction peer review publishing initiative from monthly...
A 57-year-old man with a medical history significant for bipolar disorder, depression, and anxiety presented in 2010 bilateral lower extremity numbness progressing to perineal urinary retention. "working" diagnosis of relapsing-remitting MS (RRMS) was supported by disseminated T2 hyperintensities on MRI investigations the brain spinal cord. Furthermore, CSF analysis revealed 4 unique oligoclonal bands not identified blood. The National Multiple Sclerosis Society Case Conference Proceedings...
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A 54-year-old woman presented with complaints of myalgias, fatigue, and progressive leg weakness several weeks duration, followed by acute loss vision in her left eye. Her medical history was notable for long-standing systemic lupus erythematosus (SLE) that actively treated prednisone, mycophenolate mofetil, quinacrine. The National Multiple Sclerosis Society Case Conference Proceedings are both a live educational Webinar, conjunction peer review publishing initiative from the monthly...
Continuous target-tracking tasks allow experimenters to collect perceptual data quickly and efficiently, thereby reducing the amount of time needed for an observer complete a particular task. This has potential be particularly helpful in clinical settings, where clinicians have with patients assessment and/or research can extremely limited. To explore utility continuous tasks, we designed three aimed specifically at assessing severity optic neuritis (ON), condition caused by inflammation...