A5049091840- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Conducting polymers and applications
- Neurogenesis and neuroplasticity mechanisms
- Neural Networks and Applications
- Photoreceptor and optogenetics research
- Electrochemical Analysis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Pain Management and Treatment
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Prosthetics and Rehabilitation Robotics
- Neuroscience of respiration and sleep
- Tissue Engineering and Regenerative Medicine
- Neurotransmitter Receptor Influence on Behavior
- Motor Control and Adaptation
- Alcoholism and Thiamine Deficiency
- Nicotinic Acetylcholine Receptors Study
- Axon Guidance and Neuronal Signaling
Plexon (United States)
2009-2014
Nerve Centre
2014
The University of Texas Southwestern Medical Center
2007-2009
Southwestern Medical Center
2009
Neurosciences Institute
2001-2005
John Jay College of Criminal Justice
2005
Scripps Research Institute
2002
University of North Texas
2000-2001
Abstract Carbon nanotubes (CNTs) have unique chemical and physical properties anticipated to enable broad novel biomedical applications. Yet the question concerning their biocompatibility remains controversial. We recently reported a method for rapidly preparing strong, highly electrically conducting sheets yarns from multi-walled CNTs. The present studies demonstrate that oriented 50-nm-thick semi-transparent CNT yarns, produced with minimal residual content of catalytic transition...
Abstract A novel processing method is described using photolithography to pattern thin‐film flexible electronics on shape memory polymer substrates with mechanical properties tailored improve biocompatability and enhance adhesion between the substrate metal layers. Standard semiconductor wafer techniques are adapted enable robust device design onto a variety of softening tunable moduli. The resulting devices stiff enough (shear modulus ≈700 MPa) assist implantation then soften in vivo (≈300...
Abstract Neural interfaces have traditionally been fabricated on rigid and planar substrates, including silicon engineering thermoplastics. However, the neural tissue with which these devices interact is both 3D highly compliant. The mechanical mismatch at biotic–abiotic interface expected to contribute response that limits chronic signal recording stimulation. In this work, novel ternary thiol‐ene/acrylate polymer networks are used create softening substrates for electrodes....
Cultured spinal cord networks grown on microelectrode arrays display complex patterns of spontaneous burst and spike activity. During disinhibition with bicuculline strychnine, synchronized routinely emerge. However, the variability both intra- interculture periods durations are typically large under these conditions. As a further step in simplification synaptic interactions, we blocked excitatory AMPA synapses 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzoquinoxaline-7-sulphonamide (NBQX),...
Objective. Electrical stimulation is a blunt tool for evoking neural activity. Neurons are naturally activated asynchronously and non-uniformly, whereas drives simultaneous activity within population of cells. These differences in activation pattern can result unintended side effects, including muddled sensory percepts undesirable muscle contractions. effects be mitigated by the placement electrodes close approximation to nerve fibers careful selection interface's location. This work...
Understanding the coordinated activity underlying brain computations requires large-scale, simultaneous recordings from distributed neuronal structures at a cellular-level resolution. One major hurdle to design high-bandwidth, high-precision, large-scale neural interfaces lies in formidable data streams that are generated by recorder chip and need be online transferred remote computer. The rates can require hundreds thousands of I/O pads on power consumption order Watts for streaming alone....
Abstract Objective . While prosthetic hands with independently actuated digits have become commercially available, state-of-the-art human-machine interfaces (HMI) only permit control over a limited set of grasp patterns, which does not enable amputees to experience sufficient improvement in their daily activities make an active prosthesis useful. Approach Here we present technology platform combining fully-integrated bioelectronics, implantable intrafascicular microelectrodes and deep...
Objective: Deep learning-based neural decoders have emerged as the prominent approach to enable dexterous and intuitive control of neuroprosthetic hands. Yet few studies materialized use deep learning in clinical settings due its high computational requirements. Methods: Recent advancements edge computing devices bring potential alleviate this problem. Here we present implementation a hand with embedded control. The decoder is designed based on recurrent network (RNN) architecture deployed...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> The next generation prosthetic hand that moves and feels like a real requires robust neural interconnection between the human minds machines. xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> Here we present neuroprosthetic system to demonstrate principle by employing an artificial intelligence (AI) agent translate amputee's movement intent through peripheral nerve...
We previously demonstrated that the neural cell adhesion molecule (N-CAM) inhibited proliferation of cultured rat hippocampal progenitor cells and increased number neurons generated. demonstrate here continued presence fibroblast growth factor 2 along with N-CAM or brain-derived neurotrophic over 12 days culture greatly both progenitors neurons. These progenitor-derived expressed neurotransmitters, neurotransmitter receptors, synaptic proteins in vitro consistent those mature hippocampus....
Background: Long-gap peripheral nerve defects arising from tumor, trauma, or birth-related injuries requiring reconstruction are currently treated using autografts and allografts. Autografts associated with limited supply donor-site morbidity. Allografts require administration of transient immunosuppressants, which has substantial risks. To overcome these limitations, we investigated the use detergent-free decellularized grafts to reconstruct long-gap in a rodent model compared it existing...
This paper presents a low-noise, wireless neural recorder that has frequency dependent amplification to remove electrode offset and attenuate motion artifacts. The 2.5 GQ 50 MQ input impedance at 20 Hz 1 kHz for recording local field potentials extracellular spikes, respectively. To reduce the input-referred noise, we propose low-noise frontend design with multiple novel noise suppression techniques. power consumption, have integrated an exponential component polynomial spike processor...
Rett syndrome (RTT) is caused by mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2). Although MeCP2 shows widespread expression both neuronal and non-neuronal tissues, symptoms of RTT are largely neurological. Herein, we have identified regulatory region mouse Mecp2 that sufficient for its restricted neurons. A segment (−677/+56) exhibited strong promoter activity cell lines cortical neurons, but was inactive cells glia. The necessary neuronal-specific located within a 19 bp...
We investigated whether adipose-derived adult stromal (ADAS) are of neural crest origin and the extent to which Notch 1 regulates their growth differentiation. Mouse ADAS cells cultured in media formulated for stem (NSC) displayed limited capacity self-renewal, clonogenicity, neurosphere formation compared NSC from subventricular zone hippocampus. Although expressed Nestin, GFAP, NSE Tuj1 vitro, exposure differentiation supplements did not induce mature neuronal marker expression. In...
Clinical use of neurally controlled prosthetics has advanced in recent years, but limitations still remain, including lacking fine motor control and sensory feedback. Indwelling multi-electrode arrays, cuff electrodes, regenerative sieve electrodes have been reported to serve as peripheral neural interfaces, though long-term stability the nerve-electrode interface remained a formidable challenge. We recently developed (REMI) that is able record activity early seven days post-implantation....