A5023800740- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- Natural Antidiabetic Agents Studies
- Alzheimer's disease research and treatments
- Ginseng Biological Effects and Applications
- Medicinal Plants and Neuroprotection
- melanin and skin pigmentation
- Sesame and Sesamin Research
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
- Gut microbiota and health
- RNA modifications and cancer
- Natural Products and Biological Research
- Ethnobotanical and Medicinal Plants Studies
- Tryptophan and brain disorders
- Chromatography in Natural Products
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects and Toxicity Studies
- Hair Growth and Disorders
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Skin Protection and Aging
Zhejiang University
2019-2025
Pakistan Institute of Medical Sciences
2022
University of Benin
2016
Bahauddin Zakariya University
2016
In our previous study, we found that gentiopicroside (GPS) isolated from Gentiana rigescens Franch has a significant antiaging activity via regulation of mitophagy and oxidative stress. order to increase the anti-aging GPS, several compounds based on chemical structure GPS were synthesized evaluated for bioactivity with yeast replicative lifespan assay, 2H-gentiopicroside (2H-GPS) as leading compound was selected AD treatment. To investigate whether 2H-GPS anti- Alzheimer's disease effects,...
In the present study, mice with high-fat-diet-induced obesity were used in investigating anti-obesity effects of an aqueous extract and isoquercitrin from Apocynum venetum L.
Despite many liver disorders, clinically useful drugs are scarce. Moreover, the available therapies facing challenges of efficacy and safety. Alhagi camelorum has been used in folk medicine globally for millennia to treat several ailments. (Ac) is an old plant with a significant therapeutic value throughout Africa, Asia, Latin America. Our goal was determine hepatoprotective activity against valproic acid induced hepatotoxicity using animal model.The animals were segregated 4-groups (6 male...
Silymarin is recognized for its excellent hepato-protective properties. Recent clinical studies have examined the effects of silymarin on metabolic dysfunction-associated steatotic liver disease (MASLD), highlighting necessity further exploration into optimal dosages, active components, and mechanisms action.
In the present study, replicative lifespan assay of yeast was used to guide isolation antiaging substance from Gentiana rigescens Franch, a traditional Chinese medicine. A compound with effect isolated, and chemical structure this molecule as amarogentin identified by spectral analysis compared reported data. It significantly extended K6001 at doses 1, 3, 10 μ M. Furthermore, improved survival rate under oxidative stress increasing activities catalase (CAT), superoxide dismutase (SOD),...
In previous studies, we isolated a series of novel gentisides with nerve growth factor (NGF)-mimic activities from Gentiana rigescens Franch and conducted continuous structure–activity relationship (SAR) studies. Recently, lead compound named TBG096 was discovered significant NGF-mimic activity, low toxicity, ability to pass through the blood–brain barrier (BBB). At cell level, exerts activity by regulation heat-shock cognate protein 70 (Hsc70) downstream proteins. Subsequently, high-fat...
Alhagi camelorum (AC) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The overuse of cisplatin (Cis > 50 mg/m2) associated observed nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, allergic reactions. Remedial measures are needed for the protection nephrotoxicity against cisplatin. Thus, we investigated nephroprotective effects AC extract to prevent cisplatin-induced in albino Wistar rats. presence polyphenols, phenolic...
Purpose: To investigate the ethnomedicinal claims regarding use of Acacia jacquemontii Benth. (Fabaceae) in fever, pain and inflammation.Methods: The methanol root bark extract (AJRBM) plant was used studies. Preliminary phytochemical screening carried out according to established methods. Analgesic, anti-inflammatory antipyretic activities were evaluated using acetic acid-induced writhing, carrageennan-induced rat paw edema Brewer's yeast-induced pyrexia models, respectively. administered...