A5028865299- Biomedical and Engineering Education
- Cholesterol and Lipid Metabolism
- Computational Drug Discovery Methods
- Health and Medical Research Impacts
- Bioinformatics and Genomic Networks
- Science, Research, and Medicine
- Sphingolipid Metabolism and Signaling
- Biotechnology and Related Fields
- Cell Image Analysis Techniques
- Peroxisome Proliferator-Activated Receptors
- Research Data Management Practices
- Biosimilars and Bioanalytical Methods
- Data Quality and Management
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Liver Disease Diagnosis and Treatment
- Gene Regulatory Network Analysis
- SARS-CoV-2 and COVID-19 Research
- Drug Transport and Resistance Mechanisms
- Scientific Computing and Data Management
- Innovation and Knowledge Management
- Fatty Acid Research and Health
- Technology Assessment and Management
- Antioxidant Activity and Oxidative Stress
- Health, Environment, Cognitive Aging
Center for Translational Molecular Medicine
2020-2022
John Wiley & Sons (United States)
2017
Amsterdam UMC Location University of Amsterdam
2010-2012
University of Amsterdam
2010-2012
University Medical Center Groningen
2010
Leiden University Medical Center
2010
Centre de Physiopathologie de Toulouse-Purpan
2006
Inserm
2004-2006
Université Toulouse III - Paul Sabatier
2006
Hôpital Purpan
2004-2005
Although cellular uptake of vitamin E was initially described as a passive process, recent studies in the liver and brain have shown that SR-BI (scavenger receptor class B type I) is involved this phenomenon. As expressed at high levels intestine, present study addressed involvement trafficking across enterocytes. Apical efflux main dietary forms were examined using Caco-2 TC-7 cell monolayers model human intestinal epithelium. (R,R,R)-γ-tocopherol bioavailability compared between wild-type...
Dietary cholesterol absorption contributes to a large part of the circulating cholesterol. However, mechanism sterol intestinal uptake is not clearly elucidated. Scavenger receptor class B type I (SR-BI), major component in control homeostasis, expressed intestine, but its role this organ remains unclear. We have generated transgenic mice overexpressing SR-BI primarily intestine by using mouse gene under specific "apoC-III enhancer coupled with apoA-IV promoter." found overexpression respect...
Objective— The iminosugar N -(5′-adamantane-1′-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of the enzyme glucosylceramide synthase catalyzing glycosphingolipid (GSL) biosynthesis, ameliorates diabetes and reduces liver steatosis in ob/ob mice. Because accumulation sphingolipids, including sphingomyelin GSLs, has been reported atherosclerotic lesions animal models humans, objective this study was to determine whether AMP-DNM also exerts beneficial effects on development...
Purpose Complex systems in scientific research require special efforts to develop and evolve a sustainable way. Business model innovation has become highly relevant overcome threats the sustainability of such systems, understanding it is key maintaining creating new value for community. The European Joint Programme on Rare Diseases sought create an effective rare disease ecosystem benefit patients. aim this study identify factors that could influence business environment assess overall...
This paper summarizes the proceedings of a workshop held at Trinity Hall, Cambridge to discuss comparability and includes additional information references related added subsequently workshop. Comparability is need demonstrate equivalence product after process change; recent publication states that this 'may be difficult for cell-based medicinal products'. Therefore well-managed change required which needs access good science regulatory advice developers are encouraged seek help early. The...
Personalised medicine (PM) presents a great opportunity to improve the future of individualised healthcare. Recent advances in -omics technologies have led unprecedented efforts characterising biology and molecular mechanisms that underlie development progression wide array complex human diseases, supporting further PM. This article reflects outcome 2021 EATRIS-Plus Multi-omics Stakeholder Group workshop organised 1) outline global overview common promises challenges key European...
Chemosensitivity assays are commonly used for preclinical drug discovery and clinical trial optimization. However, data from independent often discordant, largely attributed to uncharacterized variation in the experimental materials protocols. We report here launching of Minimal Information Assays (MICHA), accessed via https://micha-protocol.org. Distinguished existing efforts that lacking support integration tools, MICHA can automatically extract publicly available information facilitate...
The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of glycosphingolipid (GSL) biosynthesis is known to ameliorate diabetes, insulin sensitivity and prevent liver steatosis in ob/ob mice. Thus far the effect GSL synthesis inhibition on pre-existing NASH has not yet been assessed. To investigate it, LDLR(-/-) mice were kept a western-type diet for 12 weeks induce NASH. Next, was continued 6 presence or AMP-DNM diet. treated showed less steatosis,...
The introduction of personalized medicine, through the increasing multi-omics characterization disease, brings new challenges to disease modeling. scope this review was a broad evaluation relevance, validity, and predictive value current preclinical methodologies applied in stratified medicine approaches. Two case models were chosen: oncology brain disorders. We conducted scoping review, following Joanna Briggs Institute guidelines, searched PubMed, EMBASE, relevant databases for reports...
Abstract For life science infrastructures, sensitive data generate an additional layer of complexity. Cross-domain categorisation and discovery digital resources related to presents major interoperability challenges. To support this FAIRification process, a toolbox demonstrator aiming at for objects (e.g., regulations, guidelines, best practice, tools) has been developed. The is based upon system developed harmonised across cluster 6 research infrastructures. Three different versions were...
Chemosensitivity assays are commonly used for preclinical drug discovery and clinical trial optimization. However, data from independent often discordant, largely attributed to uncharacterized variation in the experimental materials protocols. We report here launching of MICHA (Minimal Information Assays), accessed via https://micha-protocol.org. Distinguished existing efforts that lacking support integration tools, can automatically extract publicly available information facilitate assay...
Abstract An effective response to the coronavirus disease 2019 (COVID-19) pandemic requires a better understanding of biology infection and identification validated biomarker profiles that would increase availability, accuracy, speed COVID-19 testing. Here, we describe strategic objectives action lines European Alliance Medical Research Infrastructures (AMRI), established improve research process tackle challenges related diagnostic tests development. Recommendations include: creation...
Abstract Sharing sensitive data is a specific challenge for research infrastructures in the field of life sciences. For that reason toolbox has been developed, providing resources researchers who wish to share and use data, support workflows handling these kinds digital objects. Common community approved annotations are required be compliant with FAIR principles (Findability, Accessibility, Interoperability, Reusability). The makes tagging (categorisation) system, allowing consistent...