A5002390746- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Inorganic Fluorides and Related Compounds
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Catalytic C–H Functionalization Methods
- Synthesis of Organic Compounds
- Asymmetric Hydrogenation and Catalysis
- Carbohydrate Chemistry and Synthesis
- Radical Photochemical Reactions
- Organic Chemistry Cycloaddition Reactions
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
Institut Català d'Investigació Química
2023-2024
Universitat Rovira i Virgili
2023-2024
Lanzhou University
2019-2021
Lanzhou City University
2019-2021
Northeast Normal University
2017-2018
The present work deals with a challenge in the synthesis of aryltrifluoromethyliodanes (ArICF3X) and develops direct route to PhICF3Cl via simple ligand-exchange reaction PhI(OCOCF3)2, Me3SiCF3, NaCl for first time. I-Cl bond length supports its iodonium character, which enables an enhanced CF3-transfer capability electrophilic S-, O-, N-, C-trifluoromethylations as well catalyst-free trifluoromethylation-cyclizations arylisonitriles.
The first organocatalyzed [3 + 2] cyclisation of <italic>N</italic>-2,2,2-trifluoroethylisatin ketimines with aurones has been developed.
Pharmaceutically important compounds were synthesized through the organocatalytic 1,3-dipolar cycloaddition reaction.
The scope of this review is to summarize routine asymmetric synthetic methods which enable the effective and selective introduction difluoromethyl groups into desired compounds, providing a general important research area.
A modular and practical approach has been developed for the stereoselective formation of elaborate allylic alcohols through a three-component reaction (3CR) between vinyl cyclic carbonates, olefins, various radical precursors using dual photoredox/Ni catalysis. The process expands potential radical-based alkylation to multicomponent approaches under high regio- stereocontrol with ample variation individual reagents offers access compounds featuring sterically congested functionalized...
A complete self-assistance strategy based on Me3SiCF2Br was used in the domino conversion of methylvinylketones into α,α-difluorinated cyclopentanones. Initiated by 5 mol % nBu4NBr, multistep reaction occurred one pot under mild conditions via situ formation silyl dienol ethers, difluorocyclopropanation, thermal vinylcyclopropane–cyclopentene rearrangement, and desilylation. The process takes advantage multitasking capability as difluorocarbene source, a silicon-based transfer agent, bromine...
An organocatalytic method for the asymmetric construction of CF<sub>3</sub>-containing spiro-thiazolone-pyrrolidine compounds has been developed.
An amino-controlled regiodivergent asymmetric synthesis of CF3-containing spiro-pyrrolidine-pyrazolone compounds is described. With alkaloid-derived squaramide as catalyst, the 1,3-dipolar cycloaddition α,β-unsaturated pyrazolone with diethyl 2-((2,2,2-trifluoroethyl)imino) malonate offered adducts in excellent yields, dr, and ee. While cyclohexanediamine-derived was employed, reaction afforded a series structure isomers through switched umpolung reaction.
We report here for the first time a novel difluoromethylated ketimine building block condensed by thioisatin and difluoroethylamine, offering efficient access to broad range of enantioenriched products bearing difluoroethylamine units (27 examples, ≤98% yield, >99% ee) in presence quinine-derived squaramide. Further transformation intermediate would generate variety versatile functional blocks like α-difluoromethyl amines, β-amino acid, β-diamine with retention enantiomeric excess at...
Abstract We here report a catalytic strategy to enable the decarboxylative allylic amination of vinyl cyclic carbonates using various aliphatic and nucleophilic amines. The use protic medium chelating diphosphine ligands are main drivers towards chemoselective amine formation, thereby minimizing undesired ligand‐driven complex speciation aminolysis involved substrate. This improved approach amplifies repertoire synthons that can be prepared from variety substrate combinations.