A5023685580- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Cell Adhesion Molecules Research
- Influenza Virus Research Studies
- Lipid Membrane Structure and Behavior
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Pain Management and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Cellular transport and secretion
- Mosquito-borne diseases and control
- interferon and immune responses
- RNA Interference and Gene Delivery
- Sperm and Testicular Function
- Virology and Viral Diseases
- Transcranial Magnetic Stimulation Studies
- Hepatitis B Virus Studies
- RNA and protein synthesis mechanisms
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Bacteriophages and microbial interactions
- Botulinum Toxin and Related Neurological Disorders
University of Virginia
2016-2025
Natural History Museum
2022-2024
Compass (United States)
2021-2024
University of Virginia Health System
2000-2023
South Texas Accelerated Research Therapeutics
2020-2023
Nexus Research
2022-2023
Synexus (United Kingdom)
2022-2023
Orlando Health
2023
Synexus (United States)
2022
Accelerated Medical Diagnostics (United States)
2021
Influenza virus remains a global health threat, with millions of infections annually and the impending threat that strain avian influenza may develop into human pandemic. Despite its importance as pathogen, little is known about structure, in part because intrinsic structural variability (pleiomorphy): primary distinction between spherical elongated particles, but both vary size. Pleiomorphy has thwarted analysis by image reconstruction electron micrographs based on averaging many identical...
Using chemical inhibitors and small interfering RNA (siRNA), we have confirmed roles for cathepsin B (CatB) L (CatL) in Ebola virus glycoprotein (GP)-mediated infection. Treatment of GP pseudovirions with CatB CatL converts GP1 from a 130-kDa to 19-kDa species. Virus displays significantly enhanced infection is largely resistant the effects inhibitor siRNA, but it still requires low-pH-dependent endosomal/lysosomal function. These other results support model which prime by generating...
Clomiphene and toremifene inhibit Ebola virus infection.
The highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East (MERS-CoV) cause significant morbidity morality. There is currently no approved therapeutic for coronaviruses, even as MERS-CoV spreading throughout the East. We previously screened a library of FDA-approved drugs inhibitors replication in which we identified Abelson (Abl) kinase inhibitors, including anticancer drug imatinib, both SARS-CoV vitro Here show that anti-CoV activity imatinib occurs at...
Several FDA-approved drugs, including bepridil and sertraline, may be therapeutics against filovirus infections.
In this study we tested the hypothesis that fusion mediated by influenza virus hemagglutinin (HA) is a cooperative event. To so characterized 3T3 cell lines express HA at nine different defined surface densities. densities ranged from 1.0 to 12.6 x 10(3) trimers/microns2 as determined quantitative fluorescent antibody binding. The lateral mobility and percent mobile fraction of did not vary significantly among these cells, nor contact area between HA-expressing cells target RBCs. reaction...
During replication, hepatitis delta virus (HDV) switches from production of small to large antigen. Both antigen isoforms have an HDV genome binding domain and are packaged into B (HBV)-derived envelopes but differ at their carboxyl termini. The was shown contain a terminal CXXX box undergo prenylation. large, not the small, formed secreted particles when expressed singly with HBV surface Mutation Cys 211 in abolished both prenylation particle formation, suggesting that this site is...
At low pH, the hemagglutinin (HA) of influenza virus undergoes an irreversible conformational change that potentiates its essential membrane fusion function. We have probed details this using a panel 14 anti-HA-peptide antibodies. Whereas some antibodies reacted equally well with both neutral and low-pH HA conformations, others to significantly greater extent form. The locations peptides recognized by latter in three-dimensional structure indicated regions protein response pH. Moreover,...