A5045612750- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Mesoporous Materials and Catalysis
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Nanoplatforms for cancer theranostics
- Advanced Polymer Synthesis and Characterization
- Pharmacological Effects of Natural Compounds
- Graphene and Nanomaterials Applications
- Advancements in Transdermal Drug Delivery
- Essential Oils and Antimicrobial Activity
- Antioxidant Activity and Oxidative Stress
- biodegradable polymer synthesis and properties
- Bee Products Chemical Analysis
- Analytical Chemistry and Chromatography
- Curcumin's Biomedical Applications
- Electrospun Nanofibers in Biomedical Applications
- Insect and Pesticide Research
- Chemotherapy-induced organ toxicity mitigation
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Natural product bioactivities and synthesis
- Polymer Nanocomposite Synthesis and Irradiation
- Ion channel regulation and function
Medical University of Sofia
2014-2025
Sofia University "St. Kliment Ohridski"
2013-2023
Mesoporous silica nanoparticles (MSNs) are inorganic nanocarriers presenting versatile properties and the possibility to deliver drug molecules via different routes of application. Their modification with lipids could diminish burst release profile for water-soluble molecules. In case oleic acid (OA) as a lipid component, an improvement in skin penetration can be expected. Therefore, present study, aminopropyl-functionalized MSNs were modified through carbodiimide chemistry subsequently...
The topical administration of in situ hydrogels for ocular pathologies is a promising application strategy providing high effectiveness and patient compliance. Curcumin, natural polyphenol, possesses all the prerequisites successful therapy ophthalmic diseases, but unfortunately its physicochemical properties hurdle practical use. Applying composite thermoresponsive hydrogel formulation embedded with polymer nanoparticles potent to overcome identified drawbacks. In present work we prepared...
Background/Objectives: Natural substances have been a widely studied source of both pharmaceutical excipients and drugs. Berberine (BRB) is benzylisoquinoline alkaloid isolated from different plant sources. It possesses various pharmacological properties including antibacterial, antitumor, antidiabetic, neuroprotective, hepatoprotective, anti-inflammatory, antioxidant, etc. However, the limited aqueous solubility hinders its application. Nanosized drug delivery systems are an innovative...
Hydrogels can offer many opportunities for drug delivery strategies. They be used on their own, or benefits further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes the surrounding environment utilized as gatekeepers and provide sustained on-demand release. In this study, a hybrid nanosystem temperature- pH-sensitive was prepared from MCM-41 nanoparticles grafted newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles...
The present study reports a promising antioxidant protection by recently developed micellar propolis formulation, against oxidative stress in vitro and vivo models of toxicity. based on poplar encapsulated poly(ethylene oxide)–β-poly(propylene oxide)–β-poly(ethylene oxide) triblock copolymer (PEO26–PPO40–PEO26) micelles is characterized small size (Dh = 20 nm), enhances aqueous solubility good colloidal stability. In vitro, propolis-loaded PEO26–PPO40–PEO26 (20–100 μg/ml) significantly...
Lomefloxacin (LF) is interesting as a model molecule from safety point of view because its high potential for serious adverse drug effects (i.e. phototoxic reactions). In this study, MCM-41 mesoporous silica nanoparticles (MCM-41) were loaded with lomefloxacin, aiming to overcome the drug's intrinsic cytotoxicity. The good biocompatibility empty carrier (0.1–1.0 mg/ml) was established by absence red blood cell lysis (hemolysis assay). cytotoxicity and lomefloxacin-loaded (LF-MCM-41)...
In this study, spherical hollow mesoporous silica (HMS) particles with average size of 550 nm were loaded dopamine-receptor agonist pramipexole, as a model drug. High drug loading (55%) was achieved by its incorporation in the reservoir structure HMS. The newly developed drug-delivery systems further double-coated bioadhesive polymers chitosan and sodium alginate to achieve sustained release. double chitosan/sodium coating diminished initial burst effect lowered pramipexole release at two pH...
Caffeic acid phenethyl ester (CAPE), a hydrophobic constituent of poplar propolis valuable biological activity, was immobilized in poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(ethylene oxide) (PEO-b-PCL-b-PEO) copolymer micelles to improve its solubility water. CAPE loaded the by dialysis, achieving ca. 50% encapsulation efficiency. The drug were characterized with mean diameter 39 nm, narrow size distribution and slightly positive zeta-potential (approximately 2 mV). vitro release...
Hydrogels can offer many opportunities for drug delivery strategies. They be used on their own or benefits further exploited in combination with other nanocarriers. Intelligent hydrogels that react to changes the surrounding environment utilized as gatekeepers and provide sustained demand release. In this study, a hybrid nanosystem tempera-ture pH sensitive was prepared from MCM-41 nanoparticles grafted newly synthesized thermosensitive hydrogel (MCM-41/AA-g-PnVCL). The initial particles...
Agar, a naturally occurring polysaccharide, has been modified by grafting it with acrylic (AcA) and methacrylic (McA) acid monomers, resulting in or grafted polymer (AA-g-AcA AA-g-McA) pH-sensitive swelling behavior. Different ratios between agar, initiator were applied. The synthesized grades of both new series characterized using FTIR spectroscopy, NMR, TGA, DSC, XRD to ascertain the intended grafting. percentage (% G), efficiency GE), % conversion C) calculated, models optimal...
One of the therapeutic limitations use doxorubicin (DOX) as an anticancer drug is its cardiotoxicity. Its hydrophilicity also causes difficulties in achieving sustained release. The simultaneous delivery with well-known natural antioxidant quercetin could ameliorate Thus, main aim this work to study potential carboxylated and non-carboxylated mesoporous silica MCM-41 nanoparticles for double loading hydrophilic hydrochloride hydrophobic (Q) one nanocarrier a modified release pattern reduce...
Mesoporous silica nanoparticles have been widely investigated as drug delivery systems. The present study evaluated physical stability of indomethacin loaded mesoporous MCM-41 nanoparticles. size, polydispersity index, zeta-potential, and loading degree were determined immediately after their preparation 6 months storage at 25°C in dry state. results showed insignificant changes these parameters, suggesting high indomethacin. formulated tablets by direct compression. low friability indicated...
The present study explored solvent impregnation drug loading process of the poorly soluble non-steroid anti-inflammatory indomethacin on MCM-41 type mesoporous silica carrier. Different technological factors that can influence drug-loading as time reaction, temperature, use non-solvent well different ratios between and were studied. TEM DLS used to characterize physicochemical properties obtained particles. rate dissolution studied using in-vitro release tests. Our results established...
Quercetin is a flavonoid with high antioxidant activity, and thus it an appropriate candidate for incorporation in dermal dosage forms. Unfortunately, the limited skin penetration, low water solubility chemical instability of quercetin make typically difficult sustained-release transdermal drug formulations where dissolution speed controlled mainly by physio-chemical characteristics active substance. In present study we discussed new systems delivery quercetin, based on two types mesoporous...