A5015562571- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Dietary Effects on Health
- Diet and metabolism studies
- Genetics, Aging, and Longevity in Model Organisms
National Institute for Health and Care Excellence
2022
University of Manchester
2020-2021
Diabetes Australia
2015
The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation white adipose tissue (WAT) lipogenesis and obesity. However, similar phenotype not observed under adipocyte-selective ( Flox2-6 :Adipoq Cre ), transcriptional profiling demonstrates that, basal conditions, direct targets regulation are limited, include the collagen dynamics. Under high-fat diet (HFD) feeding, mice do manifest profound obesity,...
Significance The circadian clock protein REVERBα is proposed to be a key regulator of liver metabolism. We now show that action critically dependent on metabolic state. Using transgenic mouse models, we the true role buffer against aberrant responses perturbation, rather than confer rhythmic regulation programs lipid synthesis and storage, as has been thought previously. Thus, in case metabolism, does not so much drive processes, provide protection mistimed feeding cues. Understanding how...
ABSTRACT The circadian clock component REVERBα is considered a dominant regulator of lipid metabolism, with global Reverbα deletion driving dysregulation white adipose tissue (WAT) lipogenesis and obesity. However, similar phenotype not observed under adipocyte-selective ( Flox2-6 Adipo Cre ), transcriptional profiling demonstrates that, basal conditions, direct targets regulation are limited, include the collagen dynamics. Under high-fat diet (HFD) feeding, mice do manifest profound...