A5022359214- Lymphoma Diagnosis and Treatment
- Advanced Sensor and Energy Harvesting Materials
- Ferroptosis and cancer prognosis
- Chronic Lymphocytic Leukemia Research
- Optimization and Search Problems
- Cancer Immunotherapy and Biomarkers
- Scheduling and Optimization Algorithms
- Innovative Energy Harvesting Technologies
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
- Child and Adolescent Psychosocial and Emotional Development
- Smart Parking Systems Research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Optimization and Packing Problems
- Bladder and Urothelial Cancer Treatments
- Transportation and Mobility Innovations
- Advanced Manufacturing and Logistics Optimization
- Energy Harvesting in Wireless Networks
- Immune Cell Function and Interaction
- Vibration Control and Rheological Fluids
- Epoxy Resin Curing Processes
Wenzhou Medical University
2022-2025
First Affiliated Hospital of Wenzhou Medical University
2022-2025
Foshan Hospital of TCM
2021-2024
State Key Laboratory of Crystal Materials
2024
Shandong University
2024
Tianjin Medical University General Hospital
2022-2023
Wuhan Ship Development & Design Institute
2023
Harbin Institute of Technology
2018-2022
Wenzhou University
2022
Chongqing Cancer Hospital
2022
Neuromorphic computing provides alternative hardware architectures with high computational efficiencies and low energy consumption by simulating the working principles of brain artificial neurons synapses as building blocks. This process helps overcome insurmountable speed barrier power from conventional von Neumann computer architectures. Among emerging neuromorphic electronic devices, ferroelectric-based have attracted extensive interest for their good controllability, deterministic...
Adult-onset Still's disease (AOSD) is an idiopathic systemic inflammatory of unknown aetiology. Some patients exhibit resistance to conventional treatment during long-term therapy. Janus kinase inhibitors (JAKinibs) may contribute the improvement in AOSD symptoms via JAK–signal transducer and activator transcription (STAT) pathway. We aimed explore efficacy safety baricitinib with refractory AOSD. Patients were enrolled if they fulfilled Yamaguchi classification criteria China between 2020...
Due to the molecular heterogeneity, most bladder cancer (BLCA) patients show no pathological responses immunotherapy and chemotherapy yet suffer from their toxicity. This study identified validated three distinct stable clusters of BLCA in cross-platform databases based on personalized immune inflammatory characteristics. H&E-stained histopathology images confirmed infiltration cells among clusters. Cluster-A was characterized by a favorable prognosis low but showed highest abundance...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in world, and its incidence obviously increasing. The NT5DC family has been shown to be involved progression many tumors. However, biological function members HCC still not well understood.Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan-Meier plotter, cBioPortal, GeneMANIA, Metascape, TIMER were applied assess HCC.Most highly expressed HCC. High expression NT5C2, NT5DC2, NT5DC3 was...
Abstract Crizotinib (CRIZO) has been widely employed to treat non‐small‐cell lung cancer. However, hepatic inflammatory injury is the major toxicity of CRIZO, which limits its clinical application, and underlying mechanism CRIZO‐induced hepatotoxicity not fully explored. Herein, we used cell counting kit‐8 assay flow cytometry detect cytotoxicity on human hepatocytes (HL‐7702). CRIZO significantly reduced survival rate in a dose‐dependent manner. Furthermore, reactive oxygen species (ROS)...
Background: The potential role of Neurotrophic factor-3(NTF3) in liver cancer is unknown. Therefore, we aimed to explore the clinical value NTF3 hepatocellular carcinoma (HCC). Methods: We used a variety databases analyze expression, relationship with prognosis and immune significance through bioinformatics. Results: was low expressed HCC an independent prognostic factor patients HCC. CIBERSORT analysis indicated that expression positively correlated CD4+ cells, mast NK macrophages B cells...
l-tert-leucine and its derivatives are useful as pharmaceutical active ingredients, in which leucine dehydrogenase (LeuDH) is the key enzyme their enzymatic conversions. In present study, a novel cold-adapted LeuDH, psleudh, was cloned from psychrotrophic bacteria Pseudoalteromonas sp. ANT178, isolated Antarctic sea-ice. Bioinformatics analysis of gene psleudh showed that 1209 bp length coded for 42.6 kDa protein containing 402 amino acids. PsLeuDH had conserved Phe binding site NAD⁺ site,...
In this paper, we study a courier dispatching problem (CDP) raised from an online pickup-service platform of Alibaba. The CDP aims to assign set couriers serve pickup requests with stochastic spatial and temporal arrival rate among urban regions. objective is maximize the revenue served given limited number over period time. Many algorithms such as dynamic matching vehicle routing strategy existing literature could be applied tackle problem. However, these methods rely on appropriately...
Hepatocellular carcinoma (HCC), one of the highest causes cancer-associated death, has effective treatments, especially for patients with advanced HCC. Circadian rhythm participates in several important physiological functions, and its chronic disruption results many disordered diseases, including cancer. However, role circadian overall survival (OS) HCC remains unclear.We investigated expression, copy number variation (CNV), mutation profiles core clock genes normal tumor tissues. We...
With the rapid development of microelectronics technology, low-power electronic sensors have been widely applied in many fields, such as Internet Things, aerospace, and so on. In this paper, a symmetrical ring-shaped piezoelectric energy harvester (SR-PEH) is designed to provide for sensor detect ambient temperature. The finite element method used by utilizing software COMSOL 5.4, electromechanical coupling model cantilever established. output performance equations are proposed;...
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune inflammatory disease predominantly found in women of child-bearing age. Neurogenic pulmonary edema (NPE) recalcitrant complication that occurs after injury to the central nervous system and has an acute onset rapid progression. Limbic encephalitis encephalopathy caused by viruses, immune responses, or other factors involving limbic system. NPE SLE rare.Here, we report case 21-year-old woman with who experienced five...
Vibration energy harvesting technology aims to convert mechanical into electrical through piezoelectric effect or electromagnetic induction supply for wireless sensors. Herein, based on polyvinylidene fluoride, a vibration harvester who couples and is proposed, its performance of studied from the aspects multiphysical field, microscale, circuit. First, mass‐spring‐damper model established dynamic point view, equivalent circuit models unit are view. Second, effects nonlinear magnetic...
Our study is to investigate the effects of triazole antifungal drugs on pharmacokinetics lorlatinib in rats. The samples were precipitated with methanol. Chromatographic separation was performed a ultra-performance liquid chromatography (UPLC) system using BEH C18 column. mobile phase consisted 0.1% formic acid water and Lorlatinib crizotinib (internal standard) detected multiple reaction monitoring mode. fragment ions 407.3-228.07 for m/z 450.3-260.0 crizotinib. different given Sprague...
Abstract Background The efficacy of TP53, the most widely researched mutation genetic genes in tumor, tumor metabolic reprogramming remains unclear. Methods differential analysis gene expression data information TP53 and wild-type patients were conducted to identify mutation-associated (TMGs), which used verify a signature (TMMS). Comprehensive bioinformatics analyses performed explore biological interpretability clinical application value TMMS. Results According mutation, 218 TMGs detected....
Background Lenalidomide is a thalidomide analog that has immunomodulatory and anti-angiogenic properties. The ECOC-ACRIN E1412 Phase II trial demonstrated lenalidomide, when combined with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP), extended survival in diffuse large B-cell lymphoma (DLBCL) patients. This study aimed to evaluate the cost-effectiveness of combining lenalidomide R-CHOP (R2-CHOP) versus alone as initial treatment for DLBCL from perspective Chinese...