A5013609146- High-Velocity Impact and Material Behavior
- Venous Thromboembolism Diagnosis and Management
- Blood Coagulation and Thrombosis Mechanisms
- HIV/AIDS drug development and treatment
- Energetic Materials and Combustion
- Hepatitis C virus research
- Cardiac Arrhythmias and Treatments
- Structural Response to Dynamic Loads
- Analytical Methods in Pharmaceuticals
- Biochemical and Molecular Research
- Pharmacogenetics and Drug Metabolism
- Receptor Mechanisms and Signaling
- Hydrogen Storage and Materials
- Atrial Fibrillation Management and Outcomes
- Thermal and Kinetic Analysis
- Combustion and Detonation Processes
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ammonia Synthesis and Nitrogen Reduction
- HIV Research and Treatment
- Metal-Organic Frameworks: Synthesis and Applications
- Chemical synthesis and alkaloids
- Pharmacological Effects and Toxicity Studies
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
- Hybrid Renewable Energy Systems
Boehringer Ingelheim (United States)
2014-2025
Beijing Institute of Technology
2010-2025
China Pharmaceutical University
2024
Boehringer Ingelheim (India)
2020
University of Florida
1998-2018
Boehringer Ingelheim (Australia)
2017
Columbus Oncology and Hematology Associates
2017
Boehringer Ingelheim (Germany)
2014
Janssen (United States)
2002
Johnson & Johnson (United States)
2002
The renal secretion of many drugs is facilitated by membrane transporters, including organic cation transporter 2, multidrug and toxin extrusion protein 1/2-K anion transporters 1 3. Inhibition these can reduce excretion thereby pose a safety risk. Assessing the risk inhibition investigational remains key focus in evaluation drug-drug interactions (DDIs). Current methods to predict DDI are based on generating vitro data followed clinical assessment using recommended exogenous probe substrate...
To assess the safety and pharmacokinetic pharmacodynamic characteristics of BI 135585, a selective 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) inhibitor, after single- repeated-dose administration.The single-dose study included open-label administration 200 mg 135585 in healthy volunteers, while multiple-dose study, we carried out randomized, double-blind 5-200 or placebo once daily over 14 days patients with type 2 diabetes (T2DM). Assessments 11β-HSD1 inhibition liver (urinary...
Essentials Dabigatran etexilate may provide a new treatment option for pediatric venous thromboembolism. Children aged 1 to < 12 years were given dabigatran in an open-label, single-arm study. The pharmacokinetic-pharmacodynamic relationship was similar that seen adult patients. There no serious adverse events, bleeding events or recurrent thromboembolism.Background current standard-of-care treatments thromboembolism (VTE) have limitations. (DE), direct thrombin inhibitor, offer alternative...
Abstract Venous thromboembolism (VTE) is more frequent in infants than older children. Treatment guidelines children are adapted from adult VTE data, but do not currently include direct oral anticoagulant use. Dabigatran etexilate (DE) use the paediatric population with therefore requires verification. We investigated pharmacokinetic/pharmacodynamic (PK/PD) relationship, safety and tolerability of DE liquid formulation (OLF) (aged < 12 months) who had completed standard treatment an...
Background: Pharmacokinetic drug–drug interactions (DDIs) can be caused by the effect of a pharmaceutical compound on activity one or more subtypes Cytochrome P450 (CYP) family, UDP-glucuronosyltransferases (UGTs), and/or transporters. As number therapeutic areas with polypharmacy has increased, interest grown in assessing risk DDIs during early phases drug development. Various lines research have led to improved mathematical models predict DDIs, culminating Food and Drug Administration’s...
Receptor binding studies were performed on 24 soft anticholinergic agents and 5 conventional using 4 cloned human muscarinic receptor subtypes. The measured pK i values of the ranged from 6.5 to 9.5, with majority being in range 7.5 8.5. Strong correlation was observed between is determined here pA 2 earlier guinea pig ileum contraction assays. corresponding coefficients (r 2) 0.80, 0.73, 0.81, 0.78 for i(m1), i(m2), i(m3), i(m4), respectively. Quantitative structure-activity relationship...
Background An increasing number of studies suggest that environmental pollution may increase the risk vitamin D deficiency (VDD). However, less is known about arsenic (As) exposure and VDD, particularly in Chinese pregnant women. Objectives This study examines correlations different urinary As species with serum 25 (OH) VDD prevalence. Methods We measured arsenite (As 3+ ), arsenate 5+ monomethylarsonic acid (MMA), dimethylarsinic (DMA) levels 25(OH)D 2 , 3 25(OH) 391 women Tianjin, China....
Purpose: This study aimed to explore the association between N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) single nucleotide polymorphisms (SNPs) and gestational diabetes mellitus (GDM) modification of relationship by folate vitamin B 12 .Methods: A cross-sectional involving 1303 pregnant women (262 GDM 1041 non-GDM) was performed in Tianjin, China.Nine SNPs N6AMT1 were genotyped, serum folate, , homocysteine (Hcy) levels measured.The logistic regression models determined odds ratios...
The hypervelocity impact experiments of spherical LY12 aluminum projectile diameter 6.4 mm on target thickness 23 have been conducted using a two-stage light gas gun. velocity the is 5.2, 5.7, and 6.3 km/s, respectively. experimental results show that plasma phase transition appears under current experiment conditions, expansion consists accumulation, equilibrium, attenuation. characteristic parameters decrease as expands outward are proportional with third power velocity, i.e., (Te, ne) ∝...
Background Physiological age-related changes in the haemostatic and coagulation systems result differing anticoagulant assay responses to standard anticoagulants. Therefore, we investigated response of assays dabigatran etexilate (DE) children compared with adults. Objective This article assesses relationship between plasma concentration results across age groups Patients Methods Data from three clinical trials which received DE following care for venous thromboembolism were data adult...