A5026178742- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Nutrition and Health in Aging
- Frailty in Older Adults
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Systems, Economic Evaluations, Quality of Life
- Skin Protection and Aging
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Spondyloarthritis Studies and Treatments
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- melanin and skin pigmentation
- Viral gastroenteritis research and epidemiology
- Hepatitis C virus research
- Respiratory Support and Mechanisms
- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Blood Pressure and Hypertension Studies
- Advanced Chemical Sensor Technologies
- Iron Metabolism and Disorders
- Hepatitis Viruses Studies and Epidemiology
- Occupational exposure and asthma
University of Salerno
2024
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2024
Azienda Ospedaliera G.Rummo
2019-2023
Policlinico Tor Vergata
2021
University of Rome Tor Vergata
2021
Ito Hospital
2021
Università Campus Bio-Medico
2012-2020
University of Naples Federico II
2008-2017
Federico II University Hospital
2014-2017
University of Campania "Luigi Vanvitelli"
2007
Doxycycline is used to treat infective diseases because of its broadspectrum efficacy. High dose administration (100 or 200 mg/day) often responsible for development bacterial resistances and endogenous flora alterations, whereas low doses (20-40 do not alter bacteria susceptibility antibiotics exert anti-inflammatory activities. In this study, we wanted assess the efficacy both high doxycycline in modulating IL-8, TNF-α, IL-6 gene expression HaCaT cells stimulated with LPS. Three...
Background Psoriasis is a chronic disease which requires long‐term therapy. Therefore, adherence to therapy and patient motivation are key points in controlling the disease. Mobile‐phone‐based interventions, particular text messages (TM), have already been used effectively motivate patients improve treatment many different diseases such as diabetes, cardiovascular asthma. Objectives To evaluate use of TM improving several outcomes quality life, severity, patient‐perceived severity...
Objectives To evaluate the effect of an innovative model integrating telemonitoring vital parameters and telephone support on 6‐month survival hospital admissions elderly adults with heart failure ( HF ). Design Parallel‐arm, randomized trial. Setting Geriatric acute care ward outpatient clinic at Policlinico Campus Biomedico (Rome, Italy). Participants Individuals aged 65 older (mean age 80) randomly assigned to intervention (n = 50) or control 46). had average ejection fraction 46%....
Background: Long term data on the real-life use of secukinumab are scant. The aim this study was to investigate effectiveness, safety and treatment persistence in patients with moderate-to-severe psoriasis.Research design methods: This 84-week, multicenter (n = 7) retrospective analyzed from who initiated received at least 6 months between June 2016 2018 Campania region Italy. Patient demographic characteristics, duration reasons for discontinuation as well Psoriasis Area Severity Index...
Abstract Background A universal definition of sarcopenia is still lacking. Since the European criteria have been recently revised, we aimed at studying prevalence low muscle strength (LMS) and mass (LMM), as defined according to Working Group Sarcopenia in Older People (EWGSOP) 2 1 definitions, their individual contribution toward mortality incident mobility disability a cohort community-dwelling older people. Methods Longitudinal analysis 535 participants InCHIANTI study. LMS LMM were...
The frailty phenotype (FP) proposed by Fried and colleagues (Fried LP, Tangen CM, Walston J, et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146-M156.) requires the administration of performance tests (gait speed, handgrip strength) not always feasible routine clinical practice. Furthermore, discriminative capacity instrument has been rarely investigated. Aim this study was to...
Background: Guselkumab is the first approved human IgG1λ monoclonal antibody selectively targeting p19 subunit of IL23. Its effectiveness and safety were widely reported by clinical trials. However, these results must be confirmed in real life since its deals with more complicated subjects respect to Currently, real-life data on use guselkumab following treatment failure ustekinumab are limited, existing studies usually show a small cohort and/or reduced follow-up period. In this context,...
The aims of the present study were: to examine quality life (QOL) parents children with cerebral palsy (CP) and establish possible effect behaviour problems on their QOL. One-hundred CP, aged between 4 10 years, both were included in study. Both completed WHOQOL-BREF, assess A sample 60 healthy was used as control group. primary caregiver also CHILD BEHAVIOUR CHECKLIST (CBCL). Parents CP showed lower scores physical psychological domains than group In domain mothers hemiplegia had lowest...
Some of the cytokines that have effects on melanogenesis are also reported to be involved in psoriasis.We therefore studied relationship between psoriasis and melanocytic naevi. In particular, aim our study was investigate number naevi patients with vs. controls.We performed a prospective case-control study, analysing 93 adult 174 aged-matched controls. For each participant questionnaire completed establish personal data, medical history, familial history skin cancer psoriasis. We analysed...
HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of with psoriasis receiving IT. The aim our study was to assess prevalence infection evaluate effects IT during course infection. included psoriatic who attended an Italian tertiary referral hospital from 2009 2012. A total 224 were enrolled. We evaluated: markers, type occurrence viral reactivation. observational period ranged beginning last...
The persistent circulation of hepatitis A virus (HAV) in the Mediterranean area suggests need for monitoring its presence environment. reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect HAV several consecutive raw sewage and final effluent samples, collected over an 8-month period from activated sludge treatment plant southern Italy.Two distinct purification protocols, either based on antigen-capture with monoclonal antibody (AC) or RNA extraction, were compared....
Abstract Adult atopic dermatitis (adult AD) is a systemic inflammatory disorder, whose relationship with immune-allergic and metabolic comorbidities not well established yet. Moreover, treatment of mild-to-moderate severe needs standardization among clinicians. The aim this study was to evaluate the distribution comorbidities, including abnormalities, rhinitis, conjunctivitis, asthma, alopecia sleep disturbance, according severity adult AD, describe treatments most commonly used by Italian...
Tumor necrosis factor-α (TNF-α) inhibitors represent efficacious therapeutic agents in many chronic inflammatory diseases such as psoriasis and rheumatoid arthritis. However they have been connected with increased risk of infection reactivation a variety infectious agents, viruses. The varicella zoster virus causes herpes (HZ), self-limiting, dermatomally localized, vesicular rash that can be accompanied by postherpetic neuralgia severe neurological complications.Limited information has...
Background: Analysis of exhaled volatile organic compounds (VOCs) may be applied for diagnostic purposes in some chronic diseases, but there are no data on their role discriminating people with congestive heart failure (CHF), particularly older patients where natriuretic peptides have lower accuracy. We evaluated whether VOCs analysis can discriminate or without CHF, stratify CHF severity and predict the response to therapy decompensated CHF. Methods Results: recruited 89 subjects admitted...