A5029188745- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Toxin Mechanisms and Immunotoxins
- Ginseng Biological Effects and Applications
- Andrographolide Research and Applications
- Curcumin's Biomedical Applications
- Plant Gene Expression Analysis
- Insect-Plant Interactions and Control
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Plant-Microbe Interactions and Immunity
- Fungal Plant Pathogen Control
- Antioxidant Activity and Oxidative Stress
- Postharvest Quality and Shelf Life Management
- Advanced Glycation End Products research
- Aldose Reductase and Taurine
- Genomics, phytochemicals, and oxidative stress
- Flavonoids in Medical Research
- Photosynthetic Processes and Mechanisms
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Plant tissue culture and regeneration
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Microbial Natural Products and Biosynthesis
Central Institute of Medicinal and Aromatic Plants
2015-2025
Council of Scientific and Industrial Research
2015-2025
Academy of Scientific and Innovative Research
2017-2025
Bose Institute
2016-2025
Ramakrishna Mission Vidyamandira
2024-2025
Indian Institute of Management Calcutta
2019-2021
National Institute of Plant Genome Research
2010-2016
Baylor College of Medicine
2012
Donald Danforth Plant Science Center
2010
University of British Columbia
2009
Oxidative insult, inflammation, apoptosis and autophagy play a pivotal role in the etiology of diabetic nephropathy, global health concern. Ferulic acid, phytochemical, is reported to protect against varied diseased conditions. However, ameliorative mechanisms ferulic acid averting STZ-mediated nephrotoxicity largely remains unknown. For vivo study, single intraperitoneal injection streptozotocin (50 mg kg-1 body wt.) was administered experimental rats induce diabetes. The exhibited rise...
In a globalized economy, the control of fruit ripening is strategic importance because excessive softening limits shelf life. Efforts have been made to reduce in transgenic tomato through suppression genes encoding cell wall–degrading proteins. However, these met with very limited success. N -glycans are reported play an important role during ripening, although any particular enzyme yet unknown. We identified and targeted two ripening-specific -glycoprotein modifying enzymes, α-mannosidase...
Ocimum L. of family Lamiaceae is a well known genus for its ethnobotanical, medicinal and aromatic properties, which are attributed to innumerable phenylpropanoid terpenoid compounds produced by the plant. To enrich genomic resources understanding various pathways, de novo transcriptome sequencing two important species, O. sanctum basilicum, was carried out Illumina paired-end sequencing.The sequence assembly resulted in 69117 130043 transcripts with an average length 1646 ± 1210.1 bp 1363...
Abstract Plant often responds to fungal pathogens by expressing a group of proteins known as pathogenesis-related (PRs). The expression PR is mediated through pathogen-induced signal-transduction pathways that are fine-tuned phytohormones such methyl jasmonate (MeJA). Here, we report functional characterization an Ocimum basilicum PR5 family member ( ObTLP1 ) was identified from MeJA-responsive sequence tag collection. encodes 226 amino acid polypeptide showed and structural similarities...
Abstract Sweet basil (Ocimum basilicum) is well known for its diverse pharmacological properties and has been widely used in traditional medicine the treatment of various ailments. Although a variety secondary metabolites with potent biological activities are identified, our understanding biosynthetic pathways that produce them remained largely incomplete. We studied transcriptional changes sweet after methyl jasmonate (MeJA) treatment, which considered an elicitor metabolites, identified...
Diabetic nephropathy, the leading cause of end-stage renal disease, is characterized by a proapoptotic and prooxidative environment. The mechanisms which lifestyle interventions, such as exercise, benefit diabetic nephropathy are unknown. We hypothesized that exercise inhibits early via attenuation mitochondrial apoptotic pathway oxidative damage. Type 2 db/db normoglycemic wild-type mice were exercised for an hour everyday at moderate intensity 7 wk, following function, morphology,...
Summary The medicinal plant sweet basil ( Ocimum basilicum ) accumulates bioactive ursane‐ and oleanane‐type pentacyclic triterpenes PCT s), ursolic acid oleanolic acid, respectively, in a spatio‐temporal manner; however, the biosynthetic enzymes their contributions towards biosynthesis remain to be elucidated. Two CYP 716A subfamily cytochrome P450 monooxygenases 716A252 716A253) are identified from methyl jasmonate‐responsive expression sequence tag collection functionally characterized,...
Kalmegh (Andrographis paniculata) has been widely exploited in traditional medicine for the treatment of infectious diseases and health disorders. Ent-labdane-related diterpene (ent-LRD) specialized (i.e., secondary) metabolites kalmegh such as andrographolide, neoandrographolide 14-deoxy-11,12-didehydroandrographolide, are known variety pharmacological activities. However, due to lack genomic transcriptomic information, underlying molecular basis ent-LRDs biosynthesis remained largely...
Summary Soya bean ( Glycine max ) and grass pea Lathyrus sativus seeds are important sources of dietary proteins; however, they also contain antinutritional metabolite oxalic acid OA ). Excess intake leads to nephrolithiasis due the formation calcium oxalate crystals in kidneys. Besides, is a known precursor β‐ N ‐oxalyl‐ L ‐α,β‐diaminopropionic (β‐ ODAP ), neurotoxin found pea. Here, we report reduction level soya (up 73%) 75%) by constitutive and/or seed‐specific expression an...
Pentacyclic triterpenes (PCTs) represent a major class of bioactive metabolites in banaba (Lagerstroemia speciosa) leaves; however, biosynthetic enzymes and their involvement the temporal accumulation PCTs remain to be studied. We use an integrated approach involving transcriptomics, metabolomics gene function analysis identify oxidosqualene cyclases (OSCs) cytochrome P450 monooxygenases (P450s) that catalyzed sequential cyclization oxidative reactions towards PCT scaffold diversification....
Colitis is an inflammatory disorder of the gastrointestinal tract. A widely consumed dietary nutrient, α-ketoglutarate (α-KG) known to play a crucial role in cellular metabolism and provide protection intestinal epithelium under various pathophysiological conditions. In this study, 2,4,6-trinitrobenzenesulfonic acid (TNBS) was used induce colitis Wistar rats. After 36 hours TNBS administration, rats were orally treated with solution α-KG at 1 g/kg body weight for 5 days. Development...
Excessive softening of fruits during the ripening process leads to deterioration. This is significant global importance as softening-mediated deterioration huge postharvest losses. N-glycan processing enzymes are reported play an important role climacteric fruit softening: however, date these have not been characterized in non-climacteric fruit. Two ripening-specific enzymes, α-mannosidase (α-Man) and β-D-N-acetylhexosaminidase (β-Hex), identified targeted enhance shelf life such capsicum...