A5016463511- Nitric Oxide and Endothelin Effects
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Sodium Intake and Health
- Hormonal Regulation and Hypertension
- Cardiovascular and exercise physiology
- Neuroscience of respiration and sleep
- Sexual function and dysfunction studies
- Sulfur Compounds in Biology
- Hormonal and reproductive studies
- Gout, Hyperuricemia, Uric Acid
- Heart Rate Variability and Autonomic Control
- Ion Transport and Channel Regulation
- Pregnancy and preeclampsia studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Birth, Development, and Health
- Renal and Vascular Pathologies
- Thermoregulation and physiological responses
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Sexuality, Behavior, and Technology
- Phytochemicals and Antioxidant Activities
- Pesticide Exposure and Toxicity
Universidade Federal de Santa Catarina
2022-2025
Universidade de São Paulo
2014-2023
Universidade de Ribeirão Preto
2012-2023
Universidade Federal de Alfenas
2022-2023
Universidade Federal do Amazonas
2022
Universidade Estadual do Paraná
2021
Universidade Estadual de Campinas (UNICAMP)
2011-2019
Hispanics in Philanthropy
2017
SUPERA Park of Innovation and Technology of Ribeirão Preto
2017
Clinics Hospital of Ribeirão Preto
2017
Dietary nitrite and nitrate are important sources of nitric oxide (NO). However, the use as an antihypertensive drug may be limited by increased oxidative stress associated with hypertension. We evaluated effects sodium given in drinking water for 4 weeks two-kidney one-clip (2K1C) hypertensive rats induced on NO bioavailability stress. found that, even under conditions present 2K1C hypertension, reduced systolic blood pressure a dose-dependent manner. Whereas treatment did not significantly...
This study describes the bioaccessibility in terms of total phenolic content (TPC) and antioxidant capacity before after vitro digestion from blackcurrant press cake extracts (BPC) bioactivity cell culture, human erythrocytes as well silico analysis. Chemical analysis BPC presented an increase TPC (270%) anthocyanins (136%) digestion, resulting improvement activity (DPPH 112%; FRAP: 153%). behavior may be related to highest cyanidin-3-rutinoside, confirmed by The digested did not exert...
The new pathway nitrate-nitrite-nitric oxide (NO) has emerged as a physiological alternative to the classical enzymatic for NO formation from l-arginine. Nitrate is converted nitrite by commensal bacteria in oral cavity and formed then swallowed reduced under acidic conditions of stomach. In this study, we tested hypothesis that increases gastric pH caused omeprazole could decrease hypotensive effect sodium nitrite. We assessed effects treatment on acute produced normotensive...
Hypertension is a common disease that includes oxidative stress as major feature, and impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms. While inorganic nitrite nitrate are now recognized relevant sources of NO after their bioactivation by enzymatic non-enzymatic pathways, thus lowering blood pressure, mounting evidence suggests sodium also exerts antioxidant effects. Here we show for the first time consistent systemic vascular...
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates PPIs-induced endothelial dysfunction (ED). We examined XOR impairs causes ED in rats treated with omeprazole. also omeprazole aggravates found...
Orally administered nitrite exerts antihypertensive effects associated with increased gastric nitric oxide (NO) formation. While reducing agents facilitate NO formation from nitrite, no previous study has examined whether antioxidants properties improve the responses to orally nitrite. We hypothesized that TEMPOL (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) could enhance hypotensive of in hypertensive rats by exerting antioxidant (and enhancing bioavailability) and promoting...
Abstract Upregulation of inducible nitric oxide synthase ( iNOS ) has been reported in both experimental and clinical hypertension. However, although pro‐inflammatory cytokines that up‐regulate contribute to pre‐eclampsia, no previous study tested the hypothesis a selective inhibitor (1400 W) could exert antihypertensive effects associated with decreased expression nitrosative stress pre‐eclampsia. This examined 1400 W reduced uteroplacental perfusion pressure RUPP placental ischaemia animal...
The nitric oxide (NO•) metabolites nitrite and nitrate exert antihypertensive effects by mechanisms that involve gastric formation of S-nitrosothiols. However, while the use antiseptic mouthwash (AM) is known to attenuate responses disrupting its enterosalivary cycle, there little information about whether AM attenuates orally administered nitrite. We hypothesized would not be prevented because, in contrast oral nitrate, could promote S-nitrosothiols stomach without intereference AM. Chronic...
Nitric oxide (NO)-derived metabolites including the anion nitrite can recycle back to NO and thus complement formation independent of synthases. While is as a major vascular storage pool source NO, little known about drugs that increase tissue concentrations. This study examined effects atorvastatin or sildenafil, combination, on concentrations endothelial dysfunction in 2 kidney-1 clip (2K1C) hypertension model. Sham-operated 2K1C hypertensive rats were treated with vehicle, (50 mg/Kg),...
Hypertension induces left-ventricular hypertrophy (LVH) by mechanisms involving oxidative stress and unbalanced cardiac matrix metalloproteinase (MMP) activity. We hypothesized that β1-adrenergic receptor blockers with antioxidant properties (nebivolol) could reverse hypertension-induced LVH more effectively than conventional β1-blockers (metoprolol) when used at doses exert similar antihypertensive effects. Two-kidney one-clip (2K1C) hypertension was induced in male Wistar rats. Six weeks...
Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure premature death. The anion nitrite now considered as bioactive molecule able exert beneficial cardiovascular effects. Previous results showed that attenuates hypertension-induced increases in reactive oxygen species (ROS) production the vasculature. Whether antioxidant effects induced by block critical signaling pathways involved cardiac has not been determined yet. Akt/mTOR pathway responsible...
Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, therefore complement the classic enzymatic NO synthesis. Circulating nitrite must cross membrane barriers produce their effects increased concentrations may attenuate influx into cells, decreasing generation from nitrite. Moreover, xanthine oxidoreductase (XOR) mediates formation nitrate. However, no study has examined whether attenuates XOR-mediated We hypothesized that vascular...
Abstract Glyphosate is the organophosphate pesticide most widely used in world. Recent studies correlate exposure to glyphosate and emergence of neurodevelopmental disorders. Therefore, it was objective propose a rat model perinatal glyphosate‐based herbicides (GBH) study associated Behavioral aspects brain pathways were assessed prepubertal phase. For this, maternal treatment occurred throughout entire gestation period (from GD0) until weaning on postnatal day 22 (PND 22). Control group...
Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)- 2 and promotes vascular remodeling, we hypothesized nitrite treatment at a non-antihypertensive dose exerts antioxidant effects attenuates both MMP-2 activation remodeling of hypertension. We examined the oral sodium antihypertensive (15 mg/kg) or (1 daily in hypertensive rats (two kidney, one clip; 2K1C model). Sham-operated received vehicle by gavage for four...