A5055773317- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- interferon and immune responses
- Genetics and Plant Breeding
- Influenza Virus Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Genetic Mapping and Diversity in Plants and Animals
- Yeasts and Rust Fungi Studies
- Biofuel production and bioconversion
- Rice Cultivation and Yield Improvement
- Paleontology and Stratigraphy of Fossils
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Dengue and Mosquito Control Research
- Probiotics and Fermented Foods
- Crop Yield and Soil Fertility
- Plant Gene Expression Analysis
- CRISPR and Genetic Engineering
- Plant pathogens and resistance mechanisms
- Immune Response and Inflammation
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- GABA and Rice Research
Anhui Agricultural University
2016-2025
Ministry of Agriculture and Rural Affairs
2021-2025
Guangxi Academy of Agricultural Science
2020-2025
Zhoukou Normal University
2018-2025
Rice Research Institute
2020-2025
State Grid Corporation of China (China)
2017-2024
China University of Geosciences
2022-2023
Yangzhou University
2021
Nanjing Medical University
2021
Chinese Academy of Sciences
2015-2020
Summary Anthocyanins play an important role in the growth of plants, and are beneficial to human health. In MYB‐bHLH‐WD40 (MBW) complex activates genes for anthocyanin biosynthesis. However, rice, WD40 regulators remain be conclusively identified. Here, a crucial biosynthesis gene was fine mapped 43.4‐kb genomic region on chromosome 2, OsTTG1 ( Oryza sativa TRANSPARENT TESTA GLABRA1 ) identified as ideal candidate gene. Subsequently, homozygous mutant osttg1 generated by CRISPR/Cas9 showed...
ABSTRACT The nucleoprotein (NP) is a major component of the viral ribonucleoprotein (vRNP) complex. During replication influenza virus, vRNP complex undergoes nuclear-cytoplasmic shuttling, during which NP serves as one determinants. To date, many phosphorylation sites on have been identified, but biological functions these remain unknown. In present study, S9, Y10, and Y296 were characterized. These residues are highly conserved, their was essential for virus growth in cell culture mouse...
The AP2/ERF is a large protein family of transcription factors, playing an important role in signal transduction, plant growth, development, and response to various stresses. super-family identified functionalized different but no comprehensive systematic analysis wheat ( Triticum aestivum L.) has been reported. However, genome-wide functional was performed 322 TaAP2/ERF putative genes from the genome. According phylogenetic structural analysis, were divided into 12 subfamilies (Ia, Ib, Ic,...
Influenza A virus (IAV) has developed strategies to utilize host metabolites which, after identification and isolation, can be used discover the value of immunometabolism. During this study, mimic metabolic processes influenza infection in human cells, we infect A549 cells with H1N1 (WSN) explore altered levels during first cycle using ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometer (UHPLC-Q-TOF MS) technology. We annotate MetaboAnalyst Kyoto...
Safety and reliability of transgene integration in human genome continue to pose challenges for stem cell-based gene therapy. Here, we report a baculovirus-transcription activator-like effector nuclease system AAVS1 locus-directed homologous recombination induced pluripotent cells (iPSCs). This viral system, when optimized U87 cells, provided targeted efficiency 95.21% incorporating Neo-eGFP cassette was able mediate DNA insert up 13.5 kb. In iPSCs, with persistent expression achieved...
Influenza A and B virus infections both cause a host innate immunity response. Here, we report that the robust production of type I III interferons (IFNs), IFN-stimulated genes, proinflammatory factors can be induced by influenza rather than infection in alveolar epithelial (A549) cells during early infection. This response is mainly dependent on retinoic acid-inducible gene (RIG-I)-mediated signaling pathway. Infection promotes intense Lys63-linked ubiquitination RIG-I, resulting cytokine...
Mycothiol (MSH) plays a major role in protecting cells against oxidative stress and detoxification from broad range of exogenous toxic agents. In the present study, we reveal that intracellular MSH contributes significantly to adaptation acidic conditions model organism Corynebacterium glutamicum. We evidence confers C. glutamicum with ability adapt by maintaining pHi homeostasis, scavenging reactive oxygen species (ROS), methionine synthesis S-mycothiolation modification synthase (MetE)....
ABSTRACT Leaf rust (LR) poses a global threat to wheat crops and can lead severe yield losses if environmental conditions favour its spread. Using resistant cultivars offers sustainable approach managing LR. This study aimed identify promising lines for LR‐resistance breeding using classical analytical methods screen LR tolerance. We evaluated 10 parental lines, comprising 6 4 testers, crossed into 24 combinations line × tester mating design. These germplasm were grown in triplicate RCB...
Wild rice, as the ancestor of cultivated has accumulated a wide range beneficial traits through prolonged natural selection and evolution. Oryza officinalis, belonging to CC genome, differs significantly from AA genome. In this study, we utilized second- third-generation sequencing, along with Hi-C technology, assemble genome MT10 (O. officinalis). The assembled is 552.58 Mb, contigs scaffold N50 values 40.04 44.48 respectively, 96.73% sequences anchored 12 chromosomes. A total 33,813 genes...
<title>Abstract</title> Intergeneric hybridization and domestication breeding is an efficient means for utilizing wild rice germplasm resources. In this study, we constructed gap-less genome assemblies two CC, BBCC one CCDD rices to explore the role of C subgenome in diversification. Furthermore, assembled a cultivated (AA) further developed A/C hybrids with enhanced resistance BPH using hybrid embryo rescue system. To facilitate tracking chromosomes backcross selfed progeny these hybrids,...
Abstract Nitrogen (N) is an essential nutrient for rice ( Oryza sativa L.) growth and development. However, the lower nitrogen use efficiency (NUE) results in N fertilizer surplus, which causes many environmental problems. In this study, genome‐wide association studies were used to detect nitrate reductase (NR)‐related loci 419 landraces. Using general linear model (GLM), mixed (MLM), (LM), (LMM), we found six, nine, seven, six significant single‐nucleotide polymorphisms (SNPs) associated p...
The AAVS1 locus is viewed as a 'safe harbor' for transgene insertion into human genome. In the present study, we report new method targeting in human-induced pluripotent stem cells (hiPSCs).We have developed two baculoviral transduction systems: one to deliver zinc finger nuclease (ZFN) and DNA donor template site-specific gene another mediate Cre recombinase-mediated cassette exchange system replace inserted with transgene.Our ZFN provided targeted integration efficiency of Neo-EGFP 93.8%...
Influenza A virus evades host antiviral defense through hijacking innate immunity by its non-structural protein 1 (NS1). By using mass spectrometry, threonine 80 (T80) was identified as a novel phosphorylated residue in the NS1 of influenza A/WSN/1933(H1N1). generating recombinant viruses encoding T80 mutants, roles this phosphorylation site were characterized during viral replication. The T80E (phosphomimetic) mutant attenuated replication, whereas T80A (non-phosphorylatable) did not....
The MarR family is unique to both bacteria and archaea. members of this family, one the most prevalent families transcriptional regulators in bacteria, enable adapt changing environmental conditions, such as presence antibiotics, toxic chemicals, or reactive oxygen species (ROS), mainly by thiol-disulfide switches. Although genome Corynebacterium glutamicum encodes a large number putative MarR-type regulators, their physiological biochemical functions have so far been limited only two...