A5051768222- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Retinal Diseases and Treatments
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Lung Cancer Research Studies
- Muscle Physiology and Disorders
- Cell Adhesion Molecules Research
- Protein Hydrolysis and Bioactive Peptides
- Bone and Dental Protein Studies
- Estrogen and related hormone effects
- Advanced Radiotherapy Techniques
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Air Quality and Health Impacts
- Enzyme Production and Characterization
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Connexins and lens biology
University of Liège
2013-2023
Weatherford College
2022
University of Mons
2016
Abstract Purpose: Here, we investigated the clinical relevance of an unprecedented combination three biomarkers in triple-negative breast cancer (TNBC), both human samples and patient-derived xenografts TNBC (PDX-TNBC): EGFR, its recently identified partner (MT4-MMP), retinoblastoma protein (RB). Experimental Design: IHC analyses were conducted on PDX-TNBC to evaluate production biomarkers. The sensitivity cells expressing or not MT4-MMP anti-EGFR (erlotinib) anti-CDK4/6 inhibitor...
MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol-anchored matrix metalloprotease expressed on the surface of cancer cells that promotes tumor growth and metastasis. In this report, we identify as an important driver cell proliferation through CDK4 activation retinoblastoma protein inactivation. We also determine functional link between factor receptor EGFR. Mechanistic experiments revealed direct association its positive effects EGFR phosphorylation in response to TGFα EGF cells. Notably,...
Hundreds of double homeobox (DUX) genes map within 3.3-kb repeated elements dispersed in the human genome and encode DNA-binding proteins. Among these, we identified DUX4, a potent transcription factor that causes facioscapulohumeral muscular dystrophy (FSHD). In present study, performed yeast two-hybrid screens protein co-purifications with HaloTag-DUX fusions or GST-DUX4 pull-down to identify partners DUX4c (which is identical DUX4 except for end carboxyl terminal domain) DUX1 limited...
Age-related macular degeneration (AMD) is a worldwide leading cause of blindness affecting individuals over 50 years old.The most aggressive form, wet AMD, characterized by choroidal neovascularization (CNV) and inflammation involving microglia recruitment.By using laser-induced CNV mouse model, we provide evidence for key role played miR-142-3p during formation.MiR-142-3p was overexpressed in murine lesions its pharmacological inhibition decreased vascular densities 46% 30%,...
Membrane type 4 matrix metalloproteinase ( MT 4‐ MMP ) [matrix 17] is a GPI ‐anchored membrane‐type expressed on the cell surface of human breast cancer cells. In triple‐negative cells, promotes primary tumour growth and lung metastases. Although trafficking internalization transmembrane membrane 1 have been extensively investigated, little known about regulatory mechanisms . Here, we investigated fate cellular by analysing its homophilic complex interactions, recycling dynamics as compared...
Triple-negative breast cancers (TNBC) are heterogeneous with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a type that interacts epidermal growth factor receptor (EGFR) overexpressed in >50% TNBC.We conducted retrospective immunohistochemical analysis on human TNBC samples (n=81) and validated our findings vitro vivo assays.Membrane EGFR produced 72.5% samples, whereas those proteins faintly by healthy tissues....
<div>Abstract<p>MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol–anchored matrix metalloprotease expressed on the surface of cancer cells that promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver cell proliferation through CDK4 activation retinoblastoma protein inactivation. We also determine functional link between factor receptor EGFR. Mechanistic experiments revealed direct association its positive effects EGFR phosphorylation in...
<p>Supplemental data files 2 figures including figure S1 related to 4 and Figure S2 5 6 detailed supplemental experimental procedures for methods referred in material method section RT-PCR analysis western blot analysis, inmunohistochemistry, co-immunoprecipitation, immunofluorescence vitro 3-dimensional proliferation assay DNA quantification experiments.</p>
<p>Supplemental data files 2 figures including figure S1 related to 4 and Figure S2 5 6 detailed supplemental experimental procedures for methods referred in material method section RT-PCR analysis western blot analysis, inmunohistochemistry, co-immunoprecipitation, immunofluorescence vitro 3-dimensional proliferation assay DNA quantification experiments.</p>
<div>Abstract<p>MT4-MMP (MMP-17) is a glycosylphosphatidyl inositol–anchored matrix metalloprotease expressed on the surface of cancer cells that promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver cell proliferation through CDK4 activation retinoblastoma protein inactivation. We also determine functional link between factor receptor EGFR. Mechanistic experiments revealed direct association its positive effects EGFR phosphorylation in...
<p>Supplemental data include a Supplemental Table-1, Figure 1, 2, 3, 4, 5 and 6. Table-1 is related to 1 2 Figures 3-5 are 6 5</p>
<p>Supplemental data include a Supplemental Table-1, Figure 1, 2, 3, 4, 5 and 6. Table-1 is related to 1 2 Figures 3-5 are 6 5</p>
<div>AbstractPurpose:<p>Here, we investigated the clinical relevance of an unprecedented combination three biomarkers in triple-negative breast cancer (TNBC), both human samples and patient-derived xenografts TNBC (PDX-TNBC): EGFR, its recently identified partner (MT4-MMP), retinoblastoma protein (RB).</p><p><b>Experimental Design:</b> IHC analyses were conducted on PDX-TNBC to evaluate production biomarkers. The sensitivity cells expressing or not MT4-MMP...