A5064174626- Blood Pressure and Hypertension Studies
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Nutritional Studies and Diet
- Dialysis and Renal Disease Management
- Nutrition, Genetics, and Disease
- Extracellular vesicles in disease
- Chronic Lymphocytic Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Radiopharmaceutical Chemistry and Applications
- Renal function and acid-base balance
- Bacteriophages and microbial interactions
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Adrenal Hormones and Disorders
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Pituitary Gland Disorders and Treatments
- Cardiovascular and Diving-Related Complications
- Human Health and Disease
- Lipoproteins and Cardiovascular Health
- Lymphoma Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Erythropoietin and Anemia Treatment
- Congenital Heart Disease Studies
University of Modena and Reggio Emilia
2024-2025
Istituto Superiore di Sanità
2008-2024
Sapienza University of Rome
2004-2020
Istituto Ortopedico Rizzoli
2016
AULSS 2 Marca Trevigiana
2008
Istituto Nazionale di Fisica Nucleare, Sezione di Padova
2007
University Hospital Complex Of Vigo
1999-2007
Ospedale Santa Maria della Misericordia di Rovigo
2007
Ospedale San Bortolo
1995-2003
University of Padua
1976-1999
Anti-β-glucan antibodies elicited by a laminarin-conjugate vaccine confer cross-protection to mice challenged with major fungal pathogens such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans. To gain insights into protective β-glucan epitope(s) protection mechanisms, we studied two anti-β-glucan monoclonal (mAb) identical complementarity-determining regions but different isotypes (mAb 2G8, IgG2b mAb 1E12, IgM). C. the most relevant pathogen for humans, was used model....
Overexpression of the mdr1 gene encoding P-glycoprotein (Pgp) exerts a major role in reducing effectiveness cytotoxic therapy osteosarcoma. The interaction between actin and Pgp has been shown to be instrumental establishment multidrug resistance (MDR) human tumor cells. cytoskeleton linker ezrin pivotal maintaining functional connection Pgp. We investigated multidrug-resistant osteosarcoma cell line overexpressing compared it its counterpart that overexpresses an deletion mutant. results...
ABSTRACT Introduction Liver transplantation (LT) is the sole curative option for liver failure and other primary conditions. However, limited number of suitable donors compared with growing patients requiring LT remains a leading cause mortality among those on waiting list. This has resulted in expansion criteria donor eligibility. The sequential combination ex situ reperfusion, dHOPE, NMP helps reduce occurrence ischemia–reperfusion injury assess organ viability prior to transplantation....
In chronic lymphocytic leukemia (CLL), natural killer (NK) cells show a dysfunctional phenotype that correlates with disease progression. Our aim was to restore NK cell functionality in CLL through specifically targeted IL15-stimulating activity; IL15 targeting could, fact, potentiate the activity of and reduce off-target effects. We designed developed cis-acting immunocytokine composed an anti-CD56 single-chain Fragment variable (scFv) IL15, labeled scFvB1IL15. scFvB1IL15 tested vitro on...
The survival of pediatric patients with cancer entities including osteosarcoma and Ewing's sarcoma (ES), remains extremely low hence novel treatment approaches are urgently needed. Therefore, based on the concept targeted therapy, numerous potential targets for these cancers have been evaluated pre-clinically or in some cases even clinically during last decade. In ES CD99 protein is an attractive target antigen. this respect, a new entry site therapeutic intervention may derive from specific...
Abstract Background and objectives There is an urgent need to discover blood-based biomarkers of multiple sclerosis (MS) better define the underlying biology relapses monitor disease progression. The main goal this study search for candidate MS associated with circulating extracellular vesicles (EVs), emerging tool biomarker discovery. Methods EVs, purified from unpaired plasma CSF samples RRMS patients by size-exclusion chromatography (SEC), underwent proteomic analysis novel relapses....
A hallmark of prion disease is the transformation normal cellular protein (PrPc) into an infectious disease-associated isoform, (PrPsc). Anti-prion monoclonal antibodies are invaluable for structure-function studies PrP molecules. Furthermore recent in vitro and vivo indicate that anti-PrP can prevent incorporation PrPc propagating prions. In present article, we show two new human phage antibodies, isolated on recombinant hamster (rHaPrP). We adopted antibody display strategy to isolate...
Abstract Background Severe acute respiratory syndrome (SARS)-CoV is a newly emerging virus that causes SARS with high mortality rate in infected people. Successful control of the global epidemic will require rapid and sensitive diagnostic tests to monitor its spread, as well as, development vaccines new antiviral compounds including neutralizing antibodies effectively prevent or treat this disease. Methods The human synthetic single-chain fragment variable (scFv) ETH-2 phage antibody library...
Despite biotechnological and clinical applications very few monoclonal antibodies (MAbs) directed to the enzyme glucose oxidase, have been produced so far because of heavy side effects immunization schedule for conventional MAb preparation. In contrast, phage display method allows selection human antibody fragments against any antigens, including toxic proteins. Furthermore, cDNA sequences encoding selected are readily identified, facilitating various molecular targeting approaches. order...
We report the case of a 65-year-old man affected by idiopathic thrombocytopenic purpura, who developed an acute myocardial infarction after 2 years steroid therapy. Thrombocytopenia was initially recognized 11 earlier, and became severe during past [platelets (PLTS) 10000-30000/microl]. He treated with steroids, to perform surgical procedure (prednisone 75 mg/day), subsequently maintain platelet count about 50000/microl 12.5 mg/day). After 1 year treatment, he began complain exertional...
The Aim Of This Study Is To Present A Clinical Experience Carried Out With New Device Designed Measure On-Line Urea Nitrogen Concentration In Effluent Dialysate. Biostat 1000® Monitor (Baxter Healthcare, Dirfield, Iii, Usa) Was Utilized Study. Based On Principle That Multiple Measurements Dialysate From Dialyzer, Permit Built Double Exponential Regression Leading Kinetic Parameters Dialysis Session. Data Obtained Were, Study, Compared Those By Direct Blood And Collection Whole Amount Spent...
The main target for low flux hemodialyzers is an efficient molecular weight solutes clearance. Such efficiency largely dependent on the optimization of diffusion between blood and dialysis solution. process can be impaired if there a mismatch dialysate flow distribution in dialyzer. Thus optimized both compartment becomes quintessential maximal within hemodialyzer. present paper describes flows new polysulfone hollow fiber hemodialyzer characterized by specific undulation fibers cutting...
Abstract Background The ability of cytosine deaminase (CD) to convert the antifungal agent 5-fluorocytosine (5-FC) into one most potent and largely used anticancer compound such as 5-fluorouracil (5-FU) raised considerable interest in this enzyme model gene or antibody – directed enzyme-prodrug therapy (GDEPT/ADEPT) aiming improve therapeutic ratio (benefit versus toxic side-effects) cancer chemotherapy. selection characterization a human monoclonal single chain fragment (scFv) format...