A5062421365- Medical Imaging Techniques and Applications
- Inertial Sensor and Navigation
- Adaptive Control of Nonlinear Systems
- Radiopharmaceutical Chemistry and Applications
- Nuclear Physics and Applications
- Prenatal Substance Exposure Effects
- Mass Spectrometry Techniques and Applications
- Particle accelerators and beam dynamics
- Neuroscience and Neuropharmacology Research
- Analytical Chemistry and Chromatography
- Particle Accelerators and Free-Electron Lasers
- Advanced MRI Techniques and Applications
- Robotics and Sensor-Based Localization
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- Robotic Path Planning Algorithms
- Control and Dynamics of Mobile Robots
- Neurotransmitter Receptor Influence on Behavior
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Amino Acid Enzymes and Metabolism
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Muon and positron interactions and applications
- Chemical Reactions and Isotopes
Tallinn University of Technology
2021-2024
GlaxoSmithKline (United States)
2021
South College
2021
Western University
2007-2017
Minnesota State University, Mankato
2007-2016
Lawrence Berkeley National Laboratory
2016
University of Wisconsin–Madison
1995-2013
Montana State University
2013
GlaxoSmithKline (United Kingdom)
2002-2010
Cancer Research UK
2010
Summary The potent anti-tumour activities of γδ T cells have prompted the development protocols in which γδ-agonists are administered to cancer patients. Encouraging results from small Phase I trials fuelled efforts characterize more clearly application this approach unmet clinical needs such as metastatic carcinoma. To examine breast cancer, a trial was conducted zoledronate, Vγ9Vδ2 cell agonist, plus low-dose interleukin (IL)-2 were 10 therapeutically terminal, advanced Treatment well...
Parkinson's disease (PD) is associated with increased excitatory activity within the subthalamic nucleus (STN). We sought to inhibit STN output in hemiparkinsonian macaques by transfection adeno-associated virus (AAV) containing gene for glutamic acid decarboxylase (GAD). In total, 13 were rendered right intracarotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine injection. Seven animals injected AAV-GAD into STN, and six received an AAV green fluorescent protein (GFP). Videotaped motor...
We consider the attitude and gyro-bias estimation as well stabilization problem of a rigid body in space using low-cost sensors. assume that biased measurement angular velocity is provided by gyroscope, measurements are obtained (low-pass) sensors such accelerometers magnetometers. provide an algorithm gyro - which represent true only at low frequencies Finally, proposed coupled with quaternion-based scheme, simulation results to show effectiveness algorithm.
Drug metabolism is an integral part of the drug development and discovery process. It required to validate toxicity metabolites in support safety testing particular provide information on potential form pharmacologically active or toxic metabolites. The current methodologies choice for metabolite structural elucidation are liquid chromatography/tandem mass spectrometry (LC/MS/MS) nuclear magnetic resonance (NMR) spectroscopy. There are, certain cases, examples whose sites cannot be...
The existing rigid body attitude controllers (without angular velocity measurements) involve explicitly the in feedback. Unfortunately, there does not exist any sensor that directly measures orientation of a estimation procedure). Therefore must be generated from available sensors via some determination (estimation) algorithms. most recent and efficient algorithms rely on vector measurements (which is assumed to unavailable velocity-free controllers). To overcome this circular reasoning-like...
<b><i>Objective:</i></b> To evaluate the visible and quantitative anatomic distribution of fluorine-18–labeled l-DOPA in healthy human brain, to thereby expand understanding extrastriatal sites levodopa function, provide a broader foundation for clinical research studies fluoroDOPA accumulation patients. <b><i>Methods:</i></b> The authors performed dynamic three-dimensional PET imaging 10 volunteers analyzed images visually quantitatively. Twenty-eight regions interest were applied...
Disrupted sensory processing, characterized by over‐ or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects prenatal stress and moderate‐level alcohol exposure on tactile sensitivity its relationship striatal dopamine system function thirty‐eight 5‐ 7‐year‐old rhesus monkeys. The monkeys were from four experimental conditions: (a) exposed, (b) stress, (c) exposed + (d) sucrose controls....
The metabolic routes of substrate catabolism by intact cells H. pylori have been investigated 13C NMR. Real time analyses transformations under anaerobic conditions obtained with dense cell suspensions incubated 13C-labelled pyruvate and glucose. In addition, point studies carried out aerobic conditions. Anaerobically, was rapidly metabolized to lactate, ethanol acetate. alanine produced in significant quantities provided a nitrogen source the incorporation from urea demonstrated. Under...
We present two observers that estimate the orientation of a rigid body, which is subjected to linear accelerations and rotational motion, using global positioning system (GPS) body-attached inertial measurement unit (IMU). Unlike some other attitude estimation schemes (which assume accelerometer measures gravity vector, not realistic when body subject large accelerations), proposed results belong special class velocity-aided observers, instead use true measurements (i.e., system's apparent...
This paper deals with the attitude estimation and control problems for rigid bodies, using inertial vector measurements. First, we revisit algorithm on SO(3) that has been recently proposed in literature, propose some practical extensions new insightful unit quaternion based proofs. Then, an stabilization scheme only The originality of this strategy stems from fact explicit reconstruction as well angular velocity measurements are not required anymore.
Background: Moderate prenatal alcohol exposure can cause impairments even in the absence of gross morphological defects associated with fetal syndrome. The basal ganglia, which include dopamine-rich striatum, are sensitive to alcohol-induced injury. In this study, we manipulated timing moderate-level and compared risk adverse effects on striatal dopamine (DA) system function rhesus monkeys. Methods: Thirty-five young adult monkeys (Macaca mulatta) from four groups females were assessed: (1)...
For the first time $^{18}\mathrm{F}$(p,\ensuremath{\alpha}${)}^{15}$O reaction has been studied with a $^{18}\mathrm{F}$ beam at energies which are of interest to explosive nucleosynthesis. Utilizing gas-filled magnet technique clean identification products was achieved. A resonance spin 3/${2}^{+}$ an equivalent c.m. energy 660 keV dominates yield.
GSK2798745, an antagonist of the transient receptor potential vanilloid 4 (TRPV4) ion channel, was recently investigated in clinical trials for treatment cardiac and respiratory diseases. Human plasma urine samples collected from healthy volunteers following oral administration were analyzed to identify circulating excreted metabolites parent drug. One major metabolite (1) found pooled human samples, accounting approximately half observed drug-related material. Isolation 1 followed by MS NMR...
Evaluation of sensory processing function serves as a critical component treatment planning and implementation intervention in pediatric occupational therapy practice. We developed Sensory Processing Scale for Monkeys (SPS-M), based on human tests, that measures behavioral responses to series tactile stimuli. This assessment has been used assess adult rhesus monkeys exposed prenatal alcohol, stress, or postnatal lead. Control from undisturbed pregnancies showed habituation pattern,...
Directly coupled HPLC−NMR spectroscopy has now become a standard, commercially available technique for mixture characterization. Here the extension of to chiral HPLC separation is reported and it shown that together with HPLC−CD provide complementary approaches identification structural isomers enantiomers. The general approach been exemplified using neuromuscular blocking agent atracurium besylate, which comprises 10 in various proportions as four racemic pairs two meso compounds....
Cervical intraepithelial neoplasia in postmenopausal women with negative cervical cytology Four cases of were detected among 50 whom cytological examination a smear yielded results, indicating the need for surveillance into old age. Patients, methods, and resultsCytological colposcopic cervix was performed presenting to menopausal clinic symptoms climacteric before they began hormone replacement treatment.The mean (SD) age 1 Husain DAN. Britain's failure prevent deaths from cancer.Br.