A5077938421- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Immune cells in cancer
- Tissue Engineering and Regenerative Medicine
- Distributed and Parallel Computing Systems
- Contact Dermatitis and Allergies
- Liver physiology and pathology
- Advanced Data Storage Technologies
- Parallel Computing and Optimization Techniques
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- Mast cells and histamine
- Congenital Anomalies and Fetal Surgery
- Neonatal Respiratory Health Research
- Abdominal Trauma and Injuries
PhotoBiotics (United Kingdom)
2022-2025
Bond University
2016-2024
Western University
2024
Stanford University
2023
AstraZeneca (United Kingdom)
2023
Watford General Hospital
2023
Institut du Thorax
2015-2021
Inserm
2015-2021
Centre National de la Recherche Scientifique
2015-2021
Biopolymères Interactions Assemblages
2014-2021
Spleen is known to contain multiple dendritic and myeloid cell subsets, distinguishable on the basis of phenotype, function anatomical location. As a result recent intensive flow cytometric analyses, splenic DC subsets are now better characterized than other subsets. In order identify fully characterize novel subset termed 'L-DC' in relation cells, it was necessary investigate more detail. terms surface L-DC were initially as CD11bhiCD11cloMHCII-Ly6C-Ly6G- murine spleen. Their expression...
CD9 was recently identified as a marker of murine IL-10-competent regulatory B cells. Functional impairments or defects in CD9+ IL-10-secreting cells are associated with enhanced asthma-like inflammation and airway hyperresponsiveness. In mouse models, all asthma-related features can be abrogated by cell adoptive transfer. We aimed herein to decipher the profiles, features, molecular mechanisms properties human mouse. The profile analyzed using blood from severe asthmatic patients normal...
Abstract Background Food allergies affect 4–8% of children and are constantly on the rise, thus making a timely issue. Most importantly, prevention strategies nonexistent, current therapeutic have limited efficacy need to be improved. One alternative prevent or reduce allergies, particularly during infancy, could consist modulating maternal immunity microbiota using nondigestible food ingredients, such as prebiotics. For this purpose, we studied preventive effects prebiotics in Balb/c...
Abstract The gut microbiome of cancer patients impacts response to immune checkpoint inhibitor (CPI) therapy. We have recently identified nine species commensal bacteria that are all strongly associated with CPI in four independent cohorts advanced melanoma patients. A consortium strains, each representing one these species, synergistically inhibited tumor growth combination anti-PD1 a syngeneic model thereby demonstrating as active drivers the anti-tumor response. mechanisms by which exert...
Abstract The gut microbiome of cancer patients impacts the response to immune checkpoint inhibitor (CPI) therapy. Using high precision profiling, we have recently identified 9 diverse species commensal bacteria that are all consistently and strongly associated with CPI across 4 independent cohorts melanoma patients. These represent 3 major phyla in human intestinal microbiome, include novel species. A consortium strains, each representing 1 these species, is being developed as a live...
We quantified the risk of second cancer and late mortality in a population-based Australian cohort 3273 adult (≥15 years) allogeneic hematopoietic stem cell transplant recipients (1992 to 2007). Most received nonradiation-based conditioning peripheral blood graft from matched related donor. Using record linkage with death registries, 79 cancers were identified median 3.5 years after transplantation. The competing-risk adjusted cumulative incidence was 3.35% (95% CI, 2.59 4.24) at 10 years,...
Antigen-presenting cells (APC), like dendritic (DC), are essential for T-cell activation, leading to immunity or tolerance. Multiple DC subsets each play a unique role in the immune response. Here, novel splenic dendritic-like APC has been characterized mice that function and cell surface phenotype distinct from other, described subsets. These were identified as type continuously produced spleen long-term cultures (LTC) have an vivo equivalent mice, namely 'L-DC'. This study characterizes...
Spleen is a tissue with regenerative capacity, which allows autotransplantation of human spleen fragments to counteract the effects splenectomy. We now reveal in murine model that transplant neonatal capsule alone leads regeneration full tissue. This finding indicates graft-derived stromal cells, but not lymphocytes, are essential components neogenesis, verified by and Rag1KO capsules. further demonstrate lymphotoxin lymphoid inducer cells participate two key elements bulk white pulp...
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in microenvironment leading production tissue-specific antigen presenting cells. The novel dendritic-like cell identified phenotypically functionally distinct from described In order identify these as distinct, it has been necessary show that their lineage origin progenitors...
Development of lymphoid tissue is determined by interactions between stromal organiser (LTo) and hematopoietic inducer (LTi) cells. A failure for LTo to receive appropriate activating signals during embryogenesis through lymphotoxin engagement leads a complete cessation lymph node (LN) Peyer's patch development, identifying as key population organogenesis. However, little known about the equivalent cells that induce spleen development. Here, dissociating neonatal murine re-aggregation...
Scope Food allergies result from a complex immune response involving both innate and adaptive cells. Major proteins of wheat flour, gliadins, appear to be important allergens, their characteristics can influence the allergic response. This study investigates reaction when developing food allergy gliadins in native, deamidated, or hydrolyzed forms. Methods The after one two intraperitoneal sensitizations oral challenge with each gliadin form is analyzed. Results demonstrate that deamidated...