A5048201953- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Carcinogens and Genotoxicity Assessment
- DNA Repair Mechanisms
- Radioactivity and Radon Measurements
- Advanced X-ray and CT Imaging
- Infection Control and Ventilation
- Nuclear Physics and Applications
- Radiation Effects and Dosimetry
- Skin Protection and Aging
- Metabolomics and Mass Spectrometry Studies
- Prostate Cancer Diagnosis and Treatment
- Microfluidic and Bio-sensing Technologies
- Medical Imaging Techniques and Applications
- Radioactive contamination and transfer
- Prostate Cancer Treatment and Research
- Indoor Air Quality and Microbial Exposure
- Breast Cancer Treatment Studies
- Radiation Detection and Scintillator Technologies
- Radiology practices and education
- Advances in Oncology and Radiotherapy
- Molecular Biology Techniques and Applications
- Genomic variations and chromosomal abnormalities
Columbia University
2016-2025
Columbia University Irving Medical Center
2016-2025
University Hospital Heidelberg
2022
University of California, San Diego
2022
Heidelberg University
2022
New York Hospital Queens
2010-2017
NewYork–Presbyterian Hospital
2010-2017
University of North Carolina at Chapel Hill
2017
Medical Radiological Research Center
2015
Kentucky imaging Technologies (United States)
2015
Estimated Risks of Radiation-Induced Fatal Cancer from Pediatric CTDavid J. Brenner1, Carl D. Elliston1, Eric Hall1 and Walter E. Berdon2Audio Available | Share
High doses of ionizing radiation clearly produce deleterious consequences in humans, including, but not exclusively, cancer induction. At very low the situation is much less clear, risks low-dose are societal importance relation to issues as varied screening tests for cancer, future nuclear power, occupational exposure, frequent-flyer risks, manned space exploration, and radiological terrorism. We review difficulties involved quantifying address two specific questions. First, what lowest...
Purpose: To investigate whether current fractionation and brachytherapy protraction schemes for the treatment of prostatic cancer with radiation are optimal, or could be improved.Methods Materials: We analyzed two mature data sets on radiotherapeutic tumor control prostate cancer, one using EBRT other permanent seed implants, to extract sensitivity changes in tumors. The standard linear-quadratic model was used analysis.Results: Prostatic cancers appear significantly more sensitive than most...
PURPOSE: To estimate the radiation-related cancer mortality risks associated with single or repeated full-body computed tomographic (CT) examinations by using standard radiation risk estimation methods. MATERIALS AND METHODS: The estimated dose to lung stomach from a CT examination is 14–21 mGy, which corresponds region for there direct evidence of increased in atomic bomb survivors. Total doses are correspondingly higher. authors used U.S. population derived bomb–associated data, together...
BACKGROUND In the treatment of prostate carcinoma, radiotherapy and surgery are common choices comparable efficacy; thus a realistic comparison potential long term sequelae, such as risk second malignancy, may be relevance to choice. METHODS Data regarding rate incidence from Surveillance, Epidemiology, End Results Program cancer registry (1973–1993) were used compare directly malignancy risks in 51,584 men with carcinoma who received (3549 whom developed malignancies) 70,539 underwent...
A direct approach to limit airborne viral transmissions is inactivate them within a short time of their production. Germicidal ultraviolet light, typically at 254 nm, effective in this context but, used directly, can be health hazard skin and eyes. By contrast, far-UVC light (207-222 nm) efficiently kills pathogens potentially without harm exposed human tissues. We previously demonstrated that 222-nm influenza virus we extend those studies explore efficacy against coronaviruses alpha...
PURPOSE: To estimate the radiation-related lung cancer risks associated with annual low-dose computed tomographic (CT) screening in adult smokers and former smokers, to establish a baseline risk that potential benefits of such should exceed. MATERIALS AND METHODS: The estimated radiation dose from CT examinations corresponds range for which there is direct evidence increased atomic bomb survivors. Estimated dose-, sex-, smoking status–dependent excess relative were derived incidence data...
Airborne-mediated microbial diseases such as influenza and tuberculosis represent major public health challenges. A direct approach to prevent airborne transmission is inactivation of pathogens, the antimicrobial potential UVC ultraviolet light has long been established; however, its widespread use in settings limited because conventional sources are both carcinogenic cataractogenic. By contrast, we have previously shown that far-UVC (207-222 nm) efficiently inactivates bacteria without harm...
We have previously shown that 207-nm ultraviolet (UV) light has similar antimicrobial properties as typical germicidal UV (254 nm), but without inducing mammalian skin damage. The biophysical rationale is based on the limited penetration distance of in biological samples (e.g. stratum corneum) compared with 254-nm light. Here we extended our previous studies to 222-nm and tested hypothesis there exists a narrow wavelength window far-UVC region, from around 200-222 nm, which significantly...
Many infectious diseases, including COVID-19, are transmitted by airborne pathogens. There is a need for effective environmental control measures which, ideally, not reliant on human behaviour. One potential solution Krypton Chloride (KrCl) excimer lamps (often referred to as Far-UVC), which can efficiently inactivate pathogens, such coronaviruses and influenza, in air. Research demonstrates that when KrCl filtered remove longer-wavelength ultraviolet emissions they do induce acute reactions...
Far UV-C, informally defined as electromagnetic radiation with wavelengths between 200 and 230 nm, has characteristics that are well-suited to control of airborne pathogens. Specifically, UV-C been shown be highly effective for inactivation pathogens; yet this same minimal potential cause damage human skin eye tissues. Critically, unlike UV-B, does not substantially penetrate the dead cell layer (stratum corneum) reach germinative cells in basal layer. Similarly, through corneal epithelium...
Linear algebra.- Random vectors.- Gamma, Dirichlet, and F distributions.- Invariance.- Multivariate normal.- sampling.- Wishart Tests on mean variance.- regression.- Principal components.- Canonical correlations.- Asymptotic expansions.- Robustness.- Bootstrap confidence regions tests.
Low dose rate interstitial brachytherapy is extremely useful for those tumors that are accessible an implant, while the introduction of remote afterloaders has eliminated exposure to nursing personnel. Currently, such machines require inventory many sources which loaded into catheters implanted in tumor and kept place during treatment. A significant simplification would be possible a pulsed mode, with single source moving under computer control through catheters. Assuming treatment time...
A central tenet in understanding the biological effects of ionizing radiation has been that initially affected cells were directly damaged by radiation. By contrast, evidence emerged concerning “bystander” responses involving damage to nearby not themselves traversed These long-range are interest both mechanistically and for assessing risks from low-dose exposures, where only a small proportion hit. Bystander have observed largely using single-cell vitro systems do realistic multicellular...