A5058197461- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organophosphorus compounds synthesis
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Organic and Inorganic Chemical Reactions
- Supramolecular Chemistry and Complexes
- Synthesis and Catalytic Reactions
- Organic Chemistry Cycloaddition Reactions
- Crystallography and molecular interactions
- Chemical Reaction Mechanisms
- Inorganic and Organometallic Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Molecular Junctions and Nanostructures
- Radical Photochemical Reactions
- Click Chemistry and Applications
- Synthesis of heterocyclic compounds
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mass Spectrometry Techniques and Applications
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Supramolecular Self-Assembly in Materials
Gdańsk University of Technology
2013-2024
University of Gdańsk
1994-2018
Faculty (United Kingdom)
2015-2018
Institute of Organic Chemistry
2013
Northwestern University
2007
University of Maryland, College Park
2000-2003
Lanzhou University
2002
This review summarizes the recent developments of disulfide bond formation with a variety reagents. The scope and limitations presented methods are discussed. syntheses unsymmetrical disulfides highlighted in order to present most versatile achievements.
Self-assembled monolayers (SAMs) of alkane thiols on gold and other metals are versatile constructs with which to study interfacial phenomena reactions at surfaces. Surface properties SAMs - e.g., wettability, stability in diverse environments, propensity interact or resist adsorption macromolecules -- depend can be controlled flexibly by the functional (head) groups w position alkyl chain. provide a basis for many important scientific technological applications, ranging from micropatterning...
Methylene-bridged glycoluril dimers are the fundamental building blocks of cucurbituril (CB[6]), its homologues (CB[n]), and derivatives. This paper describes three complementary methods for synthesis C- S-shaped methylene-bridged (29−34 37−44). For this purpose, we prepared derivatives (1a−d) bearing diverse functionalities on their convex face. These were alkylated under basic conditions (DMSO, t-BuOK) with 1,2-bis(halomethyl)aromatics 6−15 to yield 4a−d 16−24, which contain a single...
Dengue virus (DENV) causes 390 million infections per year. Infections can be asymptomatic or range from mild fever to severe haemorrhagic and shock syndrome. Currently, no effective antivirals safe universal vaccine is available. In the present work we tested different gold nanoparticles (AuNP) coated with ligands ω-terminated sugars bearing multiple sulfonate groups. We aimed identify compounds antiviral properties due irreversible (virucidal) rather than reversible (virustatic)...
Cucurbit[6]uril (CB[6]) is a macrocyclic compound, prepared in one pot from glycoluril and formaldehyde, whose molecular recognition properties have made it the object of intense study. Studies mechanism CB[n] formation, which might provide insights that allow tailor-made synthesis homologues derivatives, been hampered by complex structure CB[n]. By reducing complexity reaction to formation S-shaped (12S−18S) C-shaped (12C−18C) methylene bridged dimers, we able probe fundamental steps level...
We developed a fluorescent molecular probe based on gold nanoparticles functionalized with N,N′-bis(2-(1-piperazino)ethyl)-3,4,9,10-perylenetetracarboxylic acid diimide dihydrochloride, and these probes exhibit potential for applications in microscopic thermometry. The intensity of fluorescence was affected by changes temperature. Chemical environments, such as different buffers the same pH, also resulted intensities. Due to exhibited modified nanoparticles, materials are promising...
The cucurbit[n]uril (CB[n]) family of macrocycles occupies a prominent role in molecular recognition and self-assembly studies despite the current inability to access specific homologues, derivatives, analogues by straightforward tailor-made synthetic procedures. In this paper, we explore an approach that circumvents challenges posed synthesis macrocyclic CB[n] preparing 1, which functions as acyclic CB[6] congener. o-xylylene connections glycoluril rings preorganize 1 into (a,a,a,a)-1...
A novel Cas13d-based gene-editing approach has been developed to target viral RNAs in infected cells, reducing the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Zika virus (ZIKV) by up 90% compared with controls. Despite its potential, use Cas13d as an antiviral faces several challenges that limit effectiveness before reaching cells. This study presents a proof-of-concept strategy for constructing gold nanoparticles (Au_NPs) destroy SARS-CoV-2 ZIKV genomes...
The acid-catalyzed formation of methylene-bridged glycoluril dimers yields the C(2)(v)()-diastereomer selectively. Product resubmission experiments establish that selectivity is result thermodynamic control. A modified synthetic route presented allows for preparation unsymmetrically substituted dimers. We present X-ray crystal structures both diastereomers. This class compounds useful studies self-assembly in aqueous solution.
Enantiomeric self-recognition is triggered by addition of [Pd(ONO2)(en)] (2; en=1,2-ethylenediamine) to a solution (±)-1 in water, process that results 2:2 aggregate (12⋅22 and (ent-1)2⋅22) well-defined geometry. The use analytical ultracentrifugation as tool for the elucidation molecular weight stoichiometry synthetic self-assembly studies highlighted. Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2002/z18256_s.pdf or from author. Please...
We have developed a convenient method for the synthesis of functionalized unsymmetrical dialkyl trisulfanes under mild conditions in very good yields. The designed is based on reaction (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives with alkyl disulfanyl anions generated situ from <i>S</i>-acetyl and sodium methoxide. allows preparation trisulfanes bearing additional hydroxyl, carboxyl, or amino functionalities both sides trisulfane functionality.
[structure: see text] Facially amphiphilic derivatives of methylene bridged glycoluril dimers are a versatile model system for systematic studies self-assembly in water. Thorough physical organic characterization, including analytical ultracentrifugation, technique rarely used synthetic studies, allows us to conclude that this class molecules undergoes hydrophobically driven self-association yield tightly associated discrete dimeric assemblies.
We developed a simple and efficient method for the synthesis of functionalized unsymmetrical disulfanes under mild conditions in good yields.
Die Selbsterkennung von Enantiomeren wird durch die Zugabe [Pd(ONO2)(en)2] 2 (en=1,2-Ethylendiamin) zu einer wässrigen Lösung (±)-1 ausgelöst. Als Ergebnis dieses Prozesses erhält man wohldefinierte 2:2-Aggregate (12⋅22 und (ent-1)2⋅22). Der Einsatz der Ultrazentrifugierung als analytische Methode zur Bestimmung des Molekulargewichts Stöchiometrie bei Synthesestudien Selbstorganisation näher beleuchtet.
Various types of asymmetric disulfides can be synthesized under mild conditions and in excellent yields by a method involving dialkoxylthiophosphoranesulfenyl halide precursors. This straightforward, rapid procedure is used to prepare series bearing neutral, acidic, basic terminal groups as well commonly biospecific self-assembled monolayers.
We developed a simple and efficient method for the synthesis of functionalized unsymmetrical alkynyl sulfides under mild conditions in good yields.
Abstract The reactivity of thio and seleno analogs phosphoric acid 1b–f with O ‐thioacylhydroxylamine 2 was examined. experimental evidence for the proposed mechanism involving an N—O bond cleavage a single electron transfer process (SET) from phosphate anions collected. influence acids 1 structure their oxidation potentials on course reaction products 3, 4, 6, 7 distribution presented. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:767–773, 2007; Published online in InterScience (...
ABSTRACT We have developed a new method for the synthesis of functionalized symmetrical trisulfides based on (5,5‐dimethyl‐2‐thioxo‐1,3,2‐dioxa‐phosphorin‐2‐yl)disulfanyl derivatives prepared from readily available 5,5‐dimethyl‐2‐sul‐fanyl‐2‐thioxo‐1,3,2‐dioxaphosphorinane or bis(5,5‐dimethyl‐2‐thioxo‐1,3,2‐dioxaphosphorinan‐2‐yl) disulfide. The can be obtained aliphatic and aromatic thiols l ‐cysteine under mild conditions with high yield purity.
Abstract The water‐soluble calix[4]arenes based cavitands were obtained in good yield by introduction of phosphonic acids groups at the upper rim; we describe design, synthesis, and formation complexes with ephedrine, norephedrine, noradrenaline hydrochloride phosphate buffer pD 7.3. © 2004 Wiley Periodicals, Inc. Heteroatom Chem 15:155–161, 2004; Published online InterScience (www.interscience.wiley.com). DOI 10.1002/hc.10229