A5004118968- Malaria Research and Control
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Respiratory viral infections research
- Parasites and Host Interactions
- Pneumonia and Respiratory Infections
- Thermal Regulation in Medicine
- Epilepsy research and treatment
- Healthcare Systems and Technology
- SARS-CoV-2 and COVID-19 Research
- Global Maternal and Child Health
- Drug-Induced Hepatotoxicity and Protection
- Child Nutrition and Water Access
- Viral Infections and Vectors
- Electronic Health Records Systems
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Outbreaks Research
- COVID-19 epidemiological studies
- Data-Driven Disease Surveillance
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2014-2024
Kamuzu University of Health Sciences
2022-2024
University of Liverpool
2014-2024
University of Malawi
2013-2024
Kamuzu Central Hospital
2022-2024
Queen Elizabeth Central Hospital
2013-2022
Methods. From January to April 2013, 28 African countries were invited participate in a review of severe acute respiratory illness (SARI)–associated deaths identified from influenza surveillance during 2009–2012.
The Health in Action section is a forum for individuals or organizations to highlight their innovative approaches particular health problem.
We used data from 4 years of pediatric severe acute respiratory illness (SARI) sentinel surveillance in Blantyre, Malawi, to identify factors associated with clinical severity and coviral clustering. From January 2011 December 2014, 2363 children aged 3 months 14 presenting the hospital SARI were enrolled. Nasopharyngeal aspirates tested for influenza virus other viruses. assessed risk conducted clustering analysis viral clusters codetection. Hospital-attended virus-positive incidence was...
A third of children who survive malaria with neurological involvement (central nervous system [CNS] malaria) develop sequelae. higher maximum temperature (Tmax) and seizures are risk factors for
Abstract In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for elimination. We report the impact screening-and-treatment of asymptomatic Malawian schoolchildren (n = 364 in rainy season and 341 dry season) had on gametocyte—the parasite stage responsible human-to-mosquito transmission—carriage. used concomitant household-based surveys to predict potential reduction transmission surrounding community. Among 253 students with P. falciparum...
The aim of this study was to characterize the epidemiology human seasonal coronaviruses (HCoVs) in southern Malawi.
Malaria and neglected tropical diseases (NTDs), including schistosomiasis soil transmitted helminths, threaten the health of school aged in sub-Saharan Africa. Established school-based mass drug administration (MDA) programs are used to control NTDs. Recent clinical trials have shown benefit treatment malaria schools. The potential adding existing NTD has not been thoroughly evaluated. We offered with artemether-lumefantrine during routine MDA developed peer education two primary schools...
Data on the epidemiology of severe acute respiratory illness (SARI) in adults from low-income, high human immunodeficiency virus (HIV) prevalence African settings are scarce. We conducted adult SARI surveillance Blantyre, Malawi. From January 2011 to December 2013, individuals aged ≥ 15 years with (both inpatients and outpatients) were enrolled at a large teaching hospital Nasopharyngeal aspirates tested for influenza other viruses by polymerase chain reaction. estimated hospital-attended...
In areas highly endemic for malaria, Plasmodium falciparum infection prevalence peaks in school-age children, adversely affecting health and education. School-based intermittent preventive treatment reduces this burden but concerns about cost widespread use of antimalarial drugs limit enthusiasm approach. screening is an attractive alternative. a prospective cohort study, we evaluated the impact school-based on P. anemia 2 transmission settings.We screened 704 students 4 Malawian primary...
Background Malaria remains a major public health challenge in Africa where annually, ~250,000 children with malaria experience neurologic injury subsequent neuro-disability. Evidence indicates that higher temperature during the acute illness is risk factor for post-infectious sequelae. As such, aggressive antipyretic therapy may be warranted among complicated at substantial of brain injury. Previous clinical trials conducted primarily uncomplicated and using only single medication have shown...
Background Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but mortality remains high with no associated decline post-malaria neurologic injury. A randomized controlled trial aggressive antipyretic therapy acetaminophen ibuprofen (Fever RCT) for malarial fevers being conducted Malawi Zambia began enrollment...
Background: A substantial proportion of Influenza morbidity and mortality is due to secondary pneumococcal infection. Although the synergistic interaction between influenza disease well studied, interplay nasopharyngeal carriage Streptococcus pneumoniae remains unclear. We test hypothesis that infection increases susceptibility in a high HIV prevalence setting. Methods & Materials: From January December 2011, patients with severe acute respiratory (SARI), defined as fever (>38 °c), cough or...
Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial medications rapidly clear peripheral parasitemia and improve survival, but mortality remains high with no associated decline post-malaria neurologic injury. A randomized controlled trial aggressive antipyretic therapy acetaminophen ibuprofen (Fever RCT) for malarial fevers being conducted Malawi Zambia began enrollment 2019. We...
Abstract In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for elimination. We report the impact of screening-and-treatment asymptomatic schoolchildren (N=705) on gametocyte - parasite stage responsible human-to-mosquito transmission carriage and use concomitant household-based surveys to predict potential reduction in surrounding community. Among 179 students with gametocyte-containing infections, 84% had positive rapid diagnostic tests....
Abstract Background Despite ongoing eradication efforts, malaria remains a major public health challenge in Africa where annually, ~250,000 children with experience neurologic injury subsequent neurodisability. Evidence indicates that among CNS malaria, higher temperature during the acute illness is risk factor for post-infectious sequelae. As such, aggressive antipyretic therapy may be warranted, at least complicated who are substantial of brain injury. Previous clinical trials conducted...
Abstract Background In areas highly endemic for malaria, Plasmodium falciparum ( Pf ) infection prevalence peaks in school-age children, adversely affecting their health and education. School-based intermittent preventive treatment reduces this burden, however concerns about cost widespread use of antimalarial drugs have limited enthusiasm approach. screening-and-treatment is an attractive alternative. We conducted a school-based cohort study to evaluate the impact on anemia two different...