A5054050266- Sulfur Compounds in Biology
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- Paraoxonase enzyme and polymorphisms
- Biochemical effects in animals
- Birth, Development, and Health
- Redox biology and oxidative stress
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Vitamin C and Antioxidants Research
- Ovarian function and disorders
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Advanced Glycation End Products research
- Air Quality and Health Impacts
- Pregnancy and Medication Impact
- Long-Term Effects of COVID-19
- Stress Responses and Cortisol
- Obstructive Sleep Apnea Research
- Hydrogen's biological and therapeutic effects
- Tryptophan and brain disorders
- Renal function and acid-base balance
Ankara Yıldırım Beyazıt University
2016-2025
Sağlık Bilimleri Üniversitesi
2022-2025
Laboratoire de Biochimie
2021-2025
Ministry of Health
2011-2024
Memorial Ankara Hospital
2019-2024
Ankara Bilkent City Hospital
2024
University of Health Science
2023-2024
State Hospital
2016-2024
Adıyaman University
2024
City Hospital
2023-2024
The balance of oxidant and antioxidant status plays a key role in the coronary artery diseases (CAD). Thiol is one most important barriers humans, thiol/disulphide homeostasis novel oxidative stress marker.We aimed to investigate relation serum thiol levels with presence severity CAD.A total 161 patients who underwent angiography owing stable angina pectoris were consecutively enrolled. They divided into three groups. Group I - 47 age- gender-matched subjects normal (control); group II 71...
Abstract Background The most important antioxidant for erythrocytes is glutathione. In this study, a non-enzymatic recycling spectrophotometric method was developed to measure oxidized and reduced glutathione (GSH) levels in erythrocytes. newly consists of two steps. the first step, GSH were determined sample. Subsequently, total measured by reducing (GSSG) with sodium borohydride (NaBH 4 ). Half difference between gives GSSG. Results new linear 0 3000 μmol/L (r 2 = 0.999). percentage...
The aim of this study was to investigate the relation between native thiol/disulfide ratio (TDR) and severity coronary atherosclerosis as assessed by Syntax score (SXscore) in patients with non-ST elevation myocardial infarction (NSTEMI) who underwent angiography.A total 290 NSTEMI angiography, were included January August 2014. Baseline angiography determined SXscore. divided into two groups: one low SXscores (< 23) other high (≥ 23).TDR significantly lower (p < 0.001). In-hospital...
Objective The aim of this study was to evaluate the dynamic thiol–disulphide homeostasis as an oxidative stress parameter, using a newly proposed method, in patients with Alzheimer’s disease. Methods In total, 97 participants were included study. Among them, 51 had been diagnosed disease, and remaining 46 healthy individuals. Total thiol (–SH+–S–S–) levels native (–SH) serum each participant measured. amount disulphide bonds (–S–S–) ×100/(–SH), ×100/(–SH+–S–S–), –SH×100/(–SH+–S–S–) ratios...
This study investigated the value of Thiol/Disulfide homeostasis and ischemia-modified albumin (IMA) levels in discriminating diabetic cases with different stages retinopathy without retinopathy. In total, 122 patients type 2 diabetes mellitus (DM) were enrolled this prospective cross-sectional study. These separated into three subgroups: Group 1 included 42 DM no (DR), 40 having non-proliferative DR 3 had proliferative DR. The native thiol, total disulfide disulfide–native disulfide–total...
Abstract Background A crucial balance exists between oxidant and antioxidant mechanisms in the functional immune system. We aimed to evaluate contributions of these systems coronavirus disease 2019 (COVID‐19), a devastating pandemic caused by viral infection. Method analyzed serum stress parameters according clinical demographic characteristics children adults with COVID‐19 compared them against values healthy controls. Serum native thiol (NT), total (TT), disulfide, status,...
Ankylosing spondylitis (AS) is a chronic inflammatory disease. In many diseases, increased production of pro-inflammatory cytokines associated with an increase in oxidative stress mediators. Thiol/disulfide homeostasis marker for stress. The aim this study was to examine the dynamic thiol/disulfide AS. Sixty-nine patients AS and 60 age- sex-matched controls were included study. Bath Spondylitis Disease Activity Index (BASDAI) visual analogue scale (VAS) used determine disease activity....
Background/aim: Thiol status is a good reflector of the cellular redox and have vital roles in various signaling pathways. The purpose study was to investigate thiol patients with SARS-CoV-2 infection. Materials methods: A total 587 subjects (517 patients/70 healthy controls) were enrolled study.The categorized into groups regarding severity disease (mild, moderate, severe, critical).Thiol all compared. Results: had significantly diminished levels compared controls. gradually decreased as...
To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate association with clinical parameters.Forty-three pregnant women 43 healthy, uncomplicated pregnancies were included study. Native thiol, disulphide, total thiol concentrations measured by a novel automated method.The native levels significantly lower when compared healthy group (p < 0.001). There significant correlations among homeostatic parameters preeclampsia.Serum may have role pathogenesis can be...
This study aimed to investigate the blood serum levels of biomarkers specifying oxidative stress status and systemic inflammation between people using methamphetamine (METH) control group (CG). Serum thiol/disulfide balance ischemia-modified albumin were studied determine stress, interleukin-6 (IL-6) complete count (CBC) assess inflammation.Fifty patients with METH use disorder (MUD) 36 CG participants included in study. Two tubes venous samples taken measure balance, albumin, IL-6 groups....
Recently, increased reactive oxygen species (ROS), reduced antioxidant capacity, and oxidative stress have been suggested in the pathogenesis of psoriasis. The aim this study to evaluate thiol/disulfide homeostasis patients with psoriasis.Ninety psoriasis who did not receive any systemic treatment last six months were included study. Seventy-six age gender-matched healthy volunteers served as control group. Thiol/disulfide was measured venous blood samples obtained from patient groups.Native...
Thiol-disulphide homeostasis (TDH) has a critical role in various clinical disorders. We aimed to assess the association of TDH with acute tonsillopharyngitis (AT) children.This study included 94 (73 viral and 21 bacterial) patients 88 control children. Their native thiol, total disulphide levels were measured.Viral bacterial had lower thiol compared healthy children (P < 0.001 P = 0.008, respectively). Both groups 0.002 for viral, 0.011 bacterial). The than 0.04), there was significant...
Objective Aim of this study is to compare the thiol/disulfide variables before treatment, at 3rd and 6th months biologic treatment in patients with axSpA.
<title>Abstract</title> The COVID-19 pandemic has become a significant health issue due to its impact on pregnancy and the neonatal period. Research indicates that thiol-disulfide balance in pregnant women with shifts toward oxidation, linked ischemic processes disease's pathogenesis. This study investigates oxidative antioxidant levels newborns of COVID-19-positive mothers, aiming understand potential effects maternal health. single-center prospective included 35 born mothers (Group 1), 27...