About
Contact & Profiles
A5117275654
Research Areas
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
Abstract Adoptive T cell therapy (ACT) using chimeric antigen receptor (CAR) engineered cells is currently being explored in multiple cancer types beyond leukemia/lymphoma. A key step CAR-T manufacturing the activation and expansion of cells, which facilitates viral transduction, however, may hamper fitness reduce vivo persistence. We developed “T-Expand” for expansion, comprising dextran-based nanoparticles (NPs) conjugated with anti-CD3 anti-CD28 antibodies. The NPs triggered robust...
10.1101/2025.04.10.648181
preprint
EN
bioRxiv (Cold Spring Harbor Laboratory)
2025-04-16
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