A5065635267- Glaucoma and retinal disorders
- Neurological Disorders and Treatments
- Ophthalmology and Eye Disorders
- Ocular Surface and Contact Lens
- Flavonoids in Medical Research
- Retinal Diseases and Treatments
- Cerebral Venous Sinus Thrombosis
- Urticaria and Related Conditions
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Medical and Biological Sciences
- Migraine and Headache Studies
- Medicinal plant effects and applications
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Drug-Induced Ocular Toxicity
- Retinal and Optic Conditions
- Healthcare and Venom Research
- Ophthalmology and Visual Impairment Studies
- Cardiovascular Health and Disease Prevention
- Vestibular and auditory disorders
- Ocular and Laser Science Research
- Lung Cancer Diagnosis and Treatment
- Ocular Oncology and Treatments
- Diagnosis and treatment of tuberculosis
Pirogov Russian National Research Medical University
1996-2021
Moscow Clinical Scientific Center
1979
This article presents the results of an international, multicenter, randomized, double-masked, placebo-controlled clinical study Visomitin (Mitotech LLC, Moscow, Russian Federation) eye drops in patients with dry syndrome (DES). is first registered (in Russia) drug a mitochondria-targeted antioxidant (SkQ1) as active ingredient. In this multicenter (10 sites) 240 subjects DES, (Visomitin or placebo) was self-administered three times daily (TID) for 6 weeks, followed by 6-week follow-up...
Glaucoma patients frequently exhibit ocular surface side effects during treatment with prostaglandin eye drops. The present work investigated whether glaucoma suffering from signs and symptoms of disease while using preserved latanoprost drops benefited switching to preservative-free tafluprost drops.The analysis was based on 339 enrolled in two Phase IIIb trials. were required have symptoms, or one sign symptom at baseline, least 6 months preceding benzalkonium chloride. All eligible...
Aim: to determine a level of "target" intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG), depending on the disease stage. Patients and Methods: final protocol multicenter scientific analytical selective combined study conducted 6 countries (Russia, China, Belarus, Serbia, Slovakia Uzbekistan) at 25 clinical centers included data from 269 patients. The stage was confirmed by ophthalmoscopy and/or fundus photography optical coherence tomography Heidelberg tomography,...
This study investigated the efficacy and safety of tafluprost as an adjunctive therapy to timolol in patients with open-angle glaucoma or ocular hypertension, uncontrolled by monotherapy.This was a randomized, double-masked, parallel-group, multinational multicenter 12-week phase III study. Tafluprost 0.0015% (once daily: 20:10) vehicle were administered 0.5% (twice 08:00 20:00) for 6 weeks, after which all received weeks. Intraocular pressure (IOP) measurements conducted at 08:00, 10:00,...
To evaluate the influence of prolonged neuroprotective therapy on disease progression in patients with primary open-angle glaucoma (POAG) compensated intraocular pressure (IOP).The study included 147 stages I-II POAG (249 eyes) who were randomized into main (69 patients, 119 and control groups (78 130 eyes). Patients group underwent retinalamin treatment course every 6 months. examined before enrolling then 3 months during 24-months follow-up including optical coherence tomography (OCT; RNFL...
PURPOSE. To determine individual clinical and epidemiological characteristics of the disease in patients with primary openangle glaucoma (POAG) to establish its relationship adherence treatment. METHODS. The analytical, multicenter, combined study involved 1 092 subjects (2 184 eyes) different forms (general group) were selected using a survey, followed by their analysis. RESULTS. When verifying diagnosis, eyes POAG prevailed main group (from 89.6 92% all eyes). average age at final...
Six series of experiments were performed on 45 isolated cadaver eyes. In the first series, outflow facility human sclera was measured, in others, five surgical techniques for stimulating uveo‐scleral evaluated with help a constant pressure perfusion technique. It found that scleral C‐value independant and its average value equal to 0.0036 mm 3 /min/mmHg per 1 cm 2 (100 ) surface. After implantation strip into supra‐uveal space, mean increase total 23% initial value, ranging from 7 35%....
To evaluate the efficacy and safety of intramuscular Retinalamin for retinoprotection in patients with open-angle glaucoma normalized intraocular pressure (IOP).The study included 180 (355 eyes) randomized into main (n=90) control groups (n=90). The group received injections; course was repeated 6 months later. Patient examination performed at 1, 3, 6, 7, 9 12 months.Vision acuity did not change after treatment courses (p=0.3732, p=0.6862), nor (p=0.7751). IOP didn't have significant changes...
PURPOSE: To determine individual clinical and epidemiological characteristics of the disease in patients with primary open-angle glaucoma (POAG) to establish its relationship adherence treatment. MATERIALS AND METHODS: The analytical, multicenter, combined study involved 1 092 subjects (2 184 eyes) different forms (general group) were selected using a survey, followed by their analysis. RESULTS: When verifying diagnosis, eyes POAG prevailed main group (from 89.6 92% all eyes). average age at...
Aim: to assess the changes in clinical and epidemiological characteristics, diagnostic treatment options of primary open-angle glaucoma (POAG) Russian Federation multiple near- far-abroad countries over period 2005–2020. Patients Methods: final protocol this retrospective multi-center research study included 289 patients with POAG from 7 states (Russia, Belarus, Serbia, Moldova, Kyrgyzstan, Slovakia, Slovenia). The authors analyzed methods used for establishing POAP diagnosis, demographic...