A5012896876- Developmental Biology and Gene Regulation
- Wnt/β-catenin signaling in development and cancer
- Marine and coastal plant biology
- Echinoderm biology and ecology
- Marine Sponges and Natural Products
- Cancer-related gene regulation
- Animal Genetics and Reproduction
- Plant pathogens and resistance mechanisms
- Plant Parasitism and Resistance
- Plant Reproductive Biology
- Congenital heart defects research
Mississippi State University
2017-2022
Auburn University
2019-2022
The anterior neuroectoderm (ANE) in many deuterostome embryos (echinoderms, hemichordates, urochordates, cephalochordates, and vertebrates) is progressively restricted along the anterior-posterior axis to a domain around pole. In sea urchin embryo, three integrated Wnt signaling branches (Wnt/β-catenin, Wnt/JNK, Wnt/PKC) govern this progressive restriction process, which begins 32- 60-cell stage terminates by early gastrula stage. We previously have established that several secreted...
A Wnt signaling network governs early anterior-posterior (AP) specification and patterning of the deuterostome sea urchin embryo. We have previously shown that non-canonical Fzl1/2/7 antagonizes progressive posterior-to-anterior downregulation anterior neuroectoderm (ANE) gene regulatory (GRN) by canonical Wnt/β-catenin Wnt1/Wnt8-Fzl5/8-JNK signaling. This study focuses on function Wnt16 ligand during AP patterning. Maternally supplied
A combination of receptors, co-receptors, and secreted Wnt modulators form protein complexes at the cell surface that activate one or more three different signaling pathways (Wnt/β-catenin, Wnt/JNK, Wnt/Ca2+). Two these are often active in same cellular territories, forming networks; however, molecular mechanisms necessary to integrate information from situations unclear any vivo model system. Recent studies have implicated two binding receptor tyrosine kinases, kinase-like orphan (Ror)...
Remarkably few cell-to-cell signal transduction pathways are necessary during embryonic development to generate the large variety of cell types and tissues in adult body form. Yet, each year more components individual signaling discovered, studies indicate that depending on context there is significant cross-talk among most these pathways. This complexity makes studying any vivo developmental model system a difficult task. In addition, efficient functional analyses required characterize...
Remarkably few cell-to-cell signal transduction pathways are necessary during embryonic development to generate the large variety of cell types and tissues in adult body form. Yet, each year more components individual signaling discovered, studies indicate that depending on context there is significant cross-talk among most these pathways. This complexity makes studying any vivo developmental model system a difficult task. In addition, efficient functional analyses required characterize...