Areez Shafqat

ORCID: 0000-0002-1202-7214
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About
Contact & Profiles
Research Areas
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • COVID-19 Clinical Research Studies
  • Inflammasome and immune disorders
  • Cardiovascular Issues in Pregnancy
  • Long-Term Effects of COVID-19
  • SARS-CoV-2 and COVID-19 Research
  • Cardiac Health and Mental Health
  • Immune cells in cancer
  • Lymphoma Diagnosis and Treatment
  • Bladder and Urothelial Cancer Treatments
  • Meningioma and schwannoma management
  • Vascular Malformations Diagnosis and Treatment
  • Telomeres, Telomerase, and Senescence
  • Intracranial Aneurysms: Treatment and Complications
  • Renal cell carcinoma treatment
  • Amyloidosis: Diagnosis, Treatment, Outcomes
  • Vasculitis and related conditions
  • Epigenetics and DNA Methylation
  • Renal and related cancers
  • Prostate Cancer Diagnosis and Treatment
  • Sarcoma Diagnosis and Treatment
  • Diabetes Management and Research
  • Cardiac Structural Anomalies and Repair
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Viral-associated cancers and disorders

Government College University, Faisalabad
2025

Alfaisal University
2020-2024

King Saud bin Abdulaziz University for Health Sciences
2024

King Abdulaziz Medical City
2024

Aurora St. Luke's Medical Center
2024

University of Pittsburgh Medical Center
2023

St. Joseph's Hospital and Medical Center
2023

University of Maryland, Baltimore
2023

University of Miami
2023

University of Utah
2023

Neutrophils are the most abundant of circulating immune cells and first to be recruited sites inflammation. a heterogeneous group from which derived extracellular traps (NETs), reactive oxygen species, cytokines, chemokines, immunomodulatory factors, alarmins that regulate recruitment phenotypes neutrophils, macrophages, dendritic cells, T B cells. In addition, cytokine-stimulated neutrophils can express class II major histocompatibility complex internal machinery necessary for successful...

10.3390/ijms242417583 article EN International Journal of Molecular Sciences 2023-12-18

AL amyloidosis is caused by the excessive production of nonfunctional immunoglobulins, leading to formation amyloid fibrils that damage vital organs, especially heart and kidneys. presents with non-specific symptoms such as fatigue, weight loss, numbness, pain, nephrotic syndrome. Consequently, diagnosis often delayed, patients typically present advanced disease at diagnosis. The Pavia renal staging model stratifies based on their likelihood progressing dialysis. Treatment daratumumab plus...

10.3390/jcm13061744 article EN Journal of Clinical Medicine 2024-03-18

Infertility affects a significant number of couples worldwide and its incidence is increasing. While assisted reproductive technologies (ART) have revolutionized the treatment landscape infertility, present with an idiopathic cause for their hindering effective management. Profiling genome transcriptome infertile men women has revealed abnormal gene expression. Epigenetic modifications, which comprise dynamic processes that can transduce environmental signals into expression changes, may...

10.3390/genes14122132 article EN Genes 2023-11-27

Abstract Background Several studies emerging from developed countries have highlighted a significant number of potentially avoidable emergency department (ED) visits by cancer patients during the end-of-life period. However, there is paucity information developing nations regarding palliative care practices and utilization ED patients. Herein, we aim to characterize admissions among receiving at our tertiary center in Saudi Arabia. Methods This retrospective, cross-sectional study evaluating...

10.1186/s12904-024-01389-4 article EN cc-by BMC Palliative Care 2024-02-28

Covalent inhibitors play a pivotal role in the development of pharmaceutical therapies, as they form stable, irreversible bonds with target biomolecules, leading to prolonged therapeutic effects and enhanced efficacy. Since covalent first appeared late 1800s, field has become innovative rapidly, now account for around 30% all marketed therapeutics. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pandemic Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 needs be cured...

10.2174/0109298673323348241208080419 article EN Current Medicinal Chemistry 2025-01-03

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disorder. Kidney involvement, termed nephritis (LN), seen in 40–60% of patients with (SLE). After diagnosis, serial measurement proteinuria most common method monitoring treatment response and progression. However, present treatments for LN—corticosteroids immunosuppressants—target inflammation, not proteinuria. Furthermore, subclinical renal inflammation can persist despite improving Serial kidney biopsies—the gold...

10.3390/jcm13082339 article EN Journal of Clinical Medicine 2024-04-18
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