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Yee Kien Chong

ORCID: 0000-0002-1301-1695
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About
Contact & Profiles
A5082632818
Research Areas
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation
  • Immune responses and vaccinations
  • Infectious Diseases and Tuberculosis
  • HIV Research and Treatment
  • Epigenetics and DNA Methylation
  • Tuberculosis Research and Epidemiology
  • Immune Cell Function and Interaction
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Cytomegalovirus and herpesvirus research

Kyoto University
 2022

University of Malaya
 2013-2015

 Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8+ T cells in HIV/TB co-infection
OPENALEX - Publications 
Alireza Saeidi Yee Kien Chong Yean K. Yong Hong Yien Tan Muttiah Barathan and 9 more Jayakumar Rajarajeswaran Negar Shafiei Sabet Shamala Devi Sekaran Sasheela Ponnampalavanar F. Karlhans Vijayakumar Velu Adeeba Kamarulzaman Marie Larsson Esaki M. Shankar

10.1016/j.cellimm.2015.05.005 article EN Cellular Immunology 2015-05-30
 Cyclin J–CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism
OPENALEX - Publications 
Yee Kien Chong Sarang Tartey Yuki Yoshikawa Koshi Imami Songling Li and 13 more Masanori Yoshinaga Ai Hirabayashi Guohao Liu Alexis Vandenbon Fabian Hia Takuya Uehata Takashi Mino Yutaka Suzuki Takeshi Noda Dominique Ferrandon Daron M. Standley Yasushi Ishihama Osamu Takeuchi

Toll-like receptor (TLR) stimulation induces glycolysis and the production of mitochondrial reactive oxygen species (ROS), both which are critical for inflammatory responses in macrophages. Here, we demonstrated that cyclin J, a TLR-inducible member family, reduced cytokine macrophages by coordinately controlling functions. Cyclin J interacted with cyclin-dependent kinases (CDKs), increased phosphorylation subset CDK substrates, including transcription factor FoxK1 GTPase Drp1. J–dependent...

10.1126/scisignal.abm5011 article EN Science Signaling 2022-04-12
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