A5002084573- Vanadium and Halogenation Chemistry
- Oxidative Organic Chemistry Reactions
- Porphyrin and Phthalocyanine Chemistry
- Intracranial Aneurysms: Treatment and Complications
- Enzyme Catalysis and Immobilization
- Asymmetric Hydrogenation and Catalysis
- Metal-Catalyzed Oxygenation Mechanisms
- Chemical synthesis and alkaloids
Arizona State University
2022-2023
Halooxindoles are versatile building blocks for the construction of complex oxindole-containing targets biological importance. Despite their synthetic value, catalytic methods to make 3-halooxindoles from readily available starting materials have remained undisclosed. We recently discovered that chloroperoxidase Curvularia inaequalis (CiVCPO) is a viable catalyst decarboxylative bromooxidation 3-carboxyindoles furnish 3-bromooxindoles with excellent regio- and chemoselectivity. In addition...
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases capable of producing 3-haloindoles through decarboxylative halogenation 3-carboxyindoles. This biocatalytic method is applicable to chlorination, bromination, and iodination in moderate high yields with excellent chemoselectivity.
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases capable of producing 3-haloindoles through decarboxylative halogenation 3-carboxyindoles. This biocatalytic method is applicable to chlorination, bromination, and iodination in moderate high yields with excellent chemoselectivity.
Halooxindoles are versatile building blocks for the construction of complex oxindole-containing targets biological importance. Despite their synthetic value, catalytic methods to synthesize 3-halooxindoles from readily available starting materials has remained undisclosed. We recently discovered that chloroperoxidase Curvularia inaequalis (CiVCPO) is a viable catalyst decarboxylative bromooxidation 3-carboxyindoles furnish 3-bromooxindoles with excellent regio- and chemoselectivity. In...