Xiaoyu Chang

ORCID: 0000-0002-1411-985X
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About
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Research Areas
  • Social Robot Interaction and HRI
  • Computational Drug Discovery Methods
  • Infection Control and Ventilation
  • thermodynamics and calorimetric analyses
  • Field-Flow Fractionation Techniques
  • SARS-CoV-2 and COVID-19 Research
  • Protein Interaction Studies and Fluorescence Analysis
  • Death Anxiety and Social Exclusion
  • PARP inhibition in cancer therapy
  • Virtual Reality Applications and Impacts
  • Advanced Sensor and Energy Harvesting Materials
  • Geographies of human-animal interactions
  • COVID-19 diagnosis using AI
  • Protein Structure and Dynamics
  • Theatre and Performance Studies
  • Non-Invasive Vital Sign Monitoring
  • Psychology of Moral and Emotional Judgment
  • Respiratory viral infections research
  • Tuberculosis Research and Epidemiology
  • Diversity and Impact of Dance
  • Robotic Path Planning Algorithms
  • Respiratory and Cough-Related Research

Zhengzhou University
2024-2025

City University of Hong Kong
2022-2025

Abstract Wearing masks has been a recommended protective measure due to the risks of coronavirus disease 2019 (COVID‐19) even in its coming endemic phase. Therefore, deploying “smart mask” monitor human physiological signals is highly beneficial for personal and public health. This work presents smart mask integrating an ultrathin nanocomposite sponge structure‐based soundwave sensor (≈400 µm), which allows high sensitivity wide‐bandwidth dynamic pressure range, i.e., capable detecting...

10.1002/advs.202203565 article EN cc-by Advanced Science 2022-08-23

As drones become interwoven in human activities, increasingly taking on tasks interpreted as creative and performative, such choreographed light shows, there is emerging interest understanding how humans can perform together. Humans have different habits when performing with partners opposed to solo. How do people adapt their behaviors perspectives improvising robotic partners? To explore these questions, we conducted a study investigating dancer-drone interactions using system of micro...

10.1145/3613904.3642345 article EN 2024-05-11

The inhibition of twenty-five 1,2-fused/disubstituted benzimidazoles on the SARS-CoV-2 Mpro were investigated in this work. It was found that four compounds (1i, 1k, 1l, and 1m) showed obvious inhibitory effect Mpro. 1k (IC50 46.86 μM) best. UV-vis, fluorescence, CD molecular docking methods used to reveal mechanisms interaction between these Results indicated static quenching main type quenching. 1i, 1m may alter conformation microenvironment dominant forces 1i (or 1l) hydrogen bonds or van...

10.1080/07391102.2025.2466697 article EN Journal of Biomolecular Structure and Dynamics 2025-02-19

Abstract Since the outbreak of COVID‐19, one strategies used to search for potential drugs has been screen inhibitors SARS‐CoV‐2 Mpro. This work investigated inhibitory effects 4‐thiazolidinone derivatives on main protease (Mpro) using various methods, including enzyme activity assays, kinetics, spectroscopy experiments, molecular docking simulations, microscale thermophoresis, and cytotoxicity tests. Compound 3a demonstrated best inhibition effect among compounds tested, with IC 50 = 2.36 ±...

10.1002/slct.202406023 article EN ChemistrySelect 2025-04-01

Robots are increasingly deployed in crowded, large-scale environments where the demands on their services can outweigh ability to respond. When robots fail respond, humans may interpret unintended consequence negatively as a form of rejection, leading loss trust. How do service recover from such rejection remediate human trust due perceived rejection? We created task mimicking shopping malls robot arm is asked provide coffee, juice, or tea participants. rendered elsewhere, participants...

10.1145/3610977.3634959 article EN 2024-03-10

Inhibition of virus replication and inflammatory response is important for the treatment severe COVID-19 patients. RNA-dependent RNA polymerase (RdRp) indispensable SARS-CoV-2 replication, Janus kinase (JAK) 1 inhibitors exert immunosuppressive effects. RdRp/JAK1 dual-target drugs are expected to ameliorate severity disease. The N-terminal nidovirus RdRp-associated nucleotidyltransferase (NiRAN) domain RdRp a pseudokinase, it has structural similarities with JAK1. Herein, we evaluated...

10.1021/acs.jpcb.4c06123 article EN The Journal of Physical Chemistry B 2024-12-03

Abstract A global sentiment in early 2022 is that the COVID-19 virus could become endemic just like common cold flu viruses soon. The most optimistic view that, with minimal precautions, such as vaccination, boosters and optional masking, life for people will proceed normal However, warned by A. Katzourakis of Oxford University recently [1], we must set aside lazy optimism, be realistic about likely levels death, disability sickness brought on a ‘COVID-19’ endemic. Moreover, world also...

10.1101/2022.03.28.22273021 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2022-03-31
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