A5073509390- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Energetic Materials and Combustion
- Chemical Reactions and Mechanisms
- Synthesis and biological activity
- CO2 Reduction Techniques and Catalysts
- Nanomaterials for catalytic reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Reactions of Organic Compounds
- Pharmacological Receptor Mechanisms and Effects
- Electrochemical Analysis and Applications
- Chemical Synthesis and Analysis
- Molecular Junctions and Nanostructures
- Thermal and Kinetic Analysis
- Inflammatory mediators and NSAID effects
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and Biological Evaluation
- Chemical Reaction Mechanisms
Siberian Branch of the Russian Academy of Sciences
2021-2024
Institute of Energy Problems of Chemical Physics
2023
The number of candidate molecules for new non-narcotic analgesics is extremely limited. Here, we report the identification thiowurtzine, a potent analgesic molecule with promising application in chronic pain treatment. We describe chemical synthesis this unique compound derived from hexaazaisowurtzitane (CL-20) explosive molecule. Then, use animal experiments to assess its activity vivo upon chemical, thermal, and mechanical exposures, compared effect several reference drugs. Finally,...
Biologically active compounds of natural or synthetic origin have a complex structure and generally contain various structural groups among which polycyclic cage amines are found. Hexaazaisowurtzitanes representatives these studies on their biological activity began less than two decades ago, starting with research the environmental impact CL-20. This helped to evaluate risks potential pollution in habitat environments living organisms determine whether chemical question could be utilized...
Abstract The compact, nitrogen‐rich structure of 2,4,6,8,10,12‐hexaazaisowurtzitanes calls attention among researchers worldwide. These compounds have found the greatest utility as substrates for nitration to obtain caged polynitramine, 2,4,6,8,10,12‐hexanitro‐2,4,6,8,10,12‐hexaazaisowurtzitane, which possesses a high‐energy performance. All new derivatives hexaazaisowurtzitane are nitratable. present study examined process 2,6,8,12‐tetraacetyl‐2,4,6,8,10,12‐hexaazaisowurtzitane obtained...
In this work, we studied the pharmacological activity of a newly-synthesized compound 4-(3,4- dibromothiophenylcarbonyl)-10-(2-ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (M3) using somatogenic pain models various genesis (thermal and visceral pain, mechanical compression paw). The showed high antinociceptive efficacy, comparable to or exceeding that tramadol. It was shown new molecule from class hexaazaisowurtzitane effectively blocks...
A study on the Pd-catalyzed hydrodebromination of 2,3,4,5-tetrabromothiophene (1) to 3,4-dibromothiophene (2) is reported. The effect solvent nature, main agent, temperature and concentration 1 yield 2 was studied. Optimal conditions process were found: a 5 % Pd/Sibunit catalyst constituting 10 substrate weight, 80 °С, pressure 0.7 MPa, dimethyl formamide with addition triethylamine as agent in amount 2.2 equiv per initial substance 1, up 97.5 %. It shown that could be reused preservation...
В настоящее время полиазациклические соединения (азотсодержащие гетероциклические структуры) рассматриваются в качестве перспективных биологически активных веществ. Цель работы заключалась исследовании возможности получения салициловых производных инновационного анальгетика 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазаизовюрцитана по реакции ацилирования. ходе работы, на примере ацилирования хлорангидридами кислот, было установлено, что возможно введение...