A5033070880- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Smoking Behavior and Cessation
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Inflammatory Myopathies and Dermatomyositis
- Pulmonary Hypertension Research and Treatments
- Delphi Technique in Research
- Olfactory and Sensory Function Studies
- Sarcoidosis and Beryllium Toxicity Research
- Dermatologic Treatments and Research
- Muscle activation and electromyography studies
- Enzyme function and inhibition
- Literature, Language, and Rhetoric Studies
- Organometallic Compounds Synthesis and Characterization
- Occupational exposure and asthma
- Medical Imaging and Pathology Studies
- Family Support in Illness
- Disaster Response and Management
- Occupational and environmental lung diseases
- Health Literacy and Information Accessibility
Hôpital Cochin
2008-2025
Assistance Publique – Hôpitaux de Paris
2009-2024
Université Paris Cité
2005-2024
Hôpital Européen Georges-Pompidou
2022
Délégation Paris 5
2007-2013
Sorbonne Paris Cité
2013
Hôpital Necker-Enfants Malades
2008
To investigate the association of air pollution exposure with severity interstitial lung disease (ILD) at diagnosis and ILD progression among patients systemic sclerosis (SSc)-associated ILD.We conducted a retrospective two-center study SSc-associated diagnosed between 2006 2019. Exposure to pollutants particulate matter up 10 2.5 µm in diameter (PM10, PM2.5), nitrogen dioxide (NO2), ozone (O3) was assessed geolocalization coordinates patients' residential address. Logistic regression models...
BackgroundThe 6 min walk test (6MWT) provides prognostic information in various respiratory diseases, but limited data exist cystic fibrosis (CF) adults.MethodsConsecutive CF adults who performed 6MWT at Cochin Hospital (Paris, France) over 12 years were analyzed. The cut-off walking distance (6MWD) value that best predicted a combined endpoint (death without transplant or lung transplant) was established using receiver operating curve. Determinants of low 6MWD desaturation (SpO2 ≤ 90%)...
The alveolar concentration of exhaled nitric oxide (CA, NO ) is increased in patients with systemic sclerosis (SSc), but whether this increase related to the severity interstitial lung disease (ILD) SSc has not yet been investigated. In total, 58 prospectively underwent pulmonary function tests (PFTs), echocardiogram and fibrosis scoring on computed tomography (CT). Patients were divided into two groups according presence (or not) ILD. Measurements CA, assessed all compared those obtained 19...
Exhaled NO can be partitioned in its bronchial and alveolar sources, the latter may increase presence of recent asthmatic symptoms refractory asthma. The aim this multicentre prospective study was to assess whether fraction FE(NO) could associated with level asthma control severity both at time measurement subsequent 3 months.Asthma patients older than 10 years, nonsmokers, without exacerbation under regular treatment, underwent exhaled multiple constant flows allowing partition (with...
Total lung capacity (TLC) is seldom assessed in the prediction of systemic sclerosis (SSc) disease severity. To describe and analyse TLC SSc. We performed a retrospective multicentre study SSc patients enrolled French national cohort with at least one assessment, described based on baseline measurements, modelized trajectories SSc, associated measures prognosis. Two thousand three hundred forty-seven were included study. Baseline was severity survival, as well occurrence interstitial (ILD),...
The literature underscores that psychological factors could play an important role in smoking behavior, which is considered a coping mechanism. To study relations among measures of self-esteem, distress, anxiety, depressive symptoms, and styles pregnant smokers, cross-sectional was conducted. These were assessed two groups women (Smokers, n = 40; Non-smokers, 40) contacted at one University Hospital Paris. All participants filled out the Fagerström Test for Nicotine Dependence, Rosenberg...
A reduction of exhaled nitric oxide (NO) fraction and endothelial-mediated dysfunction have been reported in cystic fibrosis (CF). The aims the present study were to search for relationships between flow-independent NO exchange parameters (bronchial flux ( J ′ aw,NO ) alveolar concentration C A,NO )) lung function tests characterising airflow limitation pulmonary vascular bed (capillary blood volume physiological dead space/tidal V D / T ratio on exercise). In total, 34 patients (16...
Pulmonary sequelae as assessed by pulmonary function tests (PFTs) are often reported in patients infected SARS-CoV-2 during the post-COVID-19 period. Little is known, however, about status of inflammation clinical recovery after patients' discharge from hospitals. We prospectively measured PFTs coupled with exhaled nitric oxide (NO) stemming proximal airways (FeNO) and distal lung (CaNO) 169 consecutive varying degrees severity COVID-19 six weeks to one year acute infection SARS-CoV-2. The...
Impaired lung gas exchange is commonly seen in patients with pulmonary involvement related to SARS-CoV-2 acute infection or post-acute COVID-19 syndrome (PACS). The primary aim of our study was assess transfer, measuring the diffusion capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) all patients. Our secondary decipher respective roles perturbed membrane conductance (DM) reduced capillary volume (VC) impaired exchange. From May October 2020, we measured DLNO-DLCO 118 during their...
Interstitial lung disease (ILD) is frequent in the course of systemic sclerosis (SSc), and main cause mortality. The role air pollution has been well characterized idiopathic pulmonary fibrosis, but poorly determined SSc-associated ILD. aim our study was to evaluate correlation between exposure severity at diagnosis, progression ILD 12 24 months, survival without transplantation. We conducted a retrospective two-center including patients with diagnosed 2006 2019. Air PM<sub>10</sub>,...
A reduction of exhaled nitric oxide (NO) fraction and endothelial-mediated dysfunction have been reported in cystic fibrosis (CF). The aims the present study were to search for relationships between flow-independent NO exchange parameters (bronchial flux (J'(aw,NO)) alveolar concentration (C(A,NO))) lung function tests characterising airflow limitation pulmonary vascular bed (capillary blood volume physiological dead space/tidal (V(D)/V(T)) ratio on exercise). In total, 34 patients (16...