A5014213056- Asymmetric Synthesis and Catalysis
- Synthesis of Indole Derivatives
- Catalytic C–H Functionalization Methods
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Chemical Synthesis and Reactions
- Bioactive Compounds and Antitumor Agents
- Porphyrin and Phthalocyanine Chemistry
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Molecular Sensors and Ion Detection
- Carbohydrate Chemistry and Synthesis
- Axial and Atropisomeric Chirality Synthesis
- Luminescence and Fluorescent Materials
- Synthesis and Reactivity of Heterocycles
- Chemical Reaction Mechanisms
- Chemical Reactions and Mechanisms
- Photochromic and Fluorescence Chemistry
- Organic Electronics and Photovoltaics
Atatürk University
2015-2024
Biotechnology Institute
2024
Ankara University
2024
Indian Institute of Technology Guwahati
2023
Centre of Biomedical Research
2023
Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
2023
Universidade Nova de Lisboa
2023
Birla Institute of Technology and Science, Pilani
2023
Benemérita Universidad Autónoma de Puebla
2023
Pusan National University
2023
Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO(2) bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase corresponding sulfate. Here we prove that enzyme is catalyzing synthesis cyclic diols from sulfate esters. 5-, 6- and 8-membered ring sulfates incorporating a neighboring secondary alcohol moiety were treated CA II yielded diols. Inhibitory properties obtained original esters then...
The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1,3‐dihydropyridazine as a single product. dihydropyridazine have been dehydrogenated phenyliodine bis(trifluoroacetate) to yield corresponding pyridazines in high yield. Two stable diazines, primary product 1,4‐dihydropyridazine, were also isolated. Structures then determined by 1 H‐NMR, and 13 C‐NMR beside elemental analyses. novel pyridazine ( 8 , 9 ) efficiently inhibited cytosolic human carbonic anhydrase...
Reaction of 4,7-dihydroindole and dimethyl acetylenedicarboxylate provided a convenient route to functionalized 2-vinylindoles. Diels−Alder reactions the 2-vinylindoles with naphthoquinone, p-benzoquinone, 1,2-dicyano-4,5-dichloroquinone, N-phenyltriazolinedione, tetracyanoethylene were investigated give [c]annelated 1,2-dihydro, 1,2,3,4-tetrahydro, fully aromatized carbazoles. The structure formation mechanism both their cycloadduct are discussed.
Pd(II)-catalyzed C-H arylations of free (NH) indoles including different carbonyl directing groups on C3-position with aryl iodides are demonstrated. Importantly, the reactions carried out using same catalyst system without any additional transient group (TDG). In this study, formyl as a gave C4-arylated versus C2-arylation. Using system, functionalization 3-acetylindoles provided domino C4-arylation/3,2-carbonyl migration products. This transformation involves unusual acetyl to C2-position...
Indole derivatives are of great importance because their biological activity and application in technology.
A straightforward synthetic route toward C5-alkylated indolines/indoles has been developed. The strategy is composed of Zn(OTf)2-catalyzed Friedel–Crafts alkylation N-benzylindolines with nitroolefins, and a series diverse indolines was first obtained in up to 99% yield. This reaction provides direct practical variety the which were also utilized for accessing corresponding indoles. Indoline derivatives free NH groups could be through an N-deprotection reaction. Moreover, primary alkyl nitro...
Inverse-Diels-Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate with unsaturated bicyclic endoperoxides gave the containing pyridazine ring. The NEt(3) and CoTPP (TPP = tetraphenylporphyrin) catalyzed endoperoxide 8 resulted in formation hydroxy ketone 11 cis-diol 9. Cleavage peroxide linkage thiourea provided Oxidation 9 led to phthalazine-5,8-dione 10. Furthermore, various transformations other 19, 20, 22, 23, 30 derivatives.
The electrophilic substitution reaction of 4,7-dihydroindole with aryl-aldehydes as an partner followed by oxidation step to deliver 2,2′-bis(indolyl)arylmethanes was studied for the first time. afforded regioselectivity at 2,2′-positions indole in operationally simple and inexpensive procedure a variety substrates. To best our knowledge, this is set examples obtained substituent-free manner. A facile method from dipyrromethanes corresponding 2-benzylindoles also reported. In addition, were...
Aggregation-induced emission (AIE) is an extraordinary photochemical phenomenon described by Tang's group in 2001, where the aggregation of some organic molecules enhances their light limiting intramolecular activity aggregate state. This offers new opportunities for researchers due to its potential applications optoelectronics, energy, and biophysics. Tetraphenylethylenes (TPEs) are reliable AIE luminogens with a wide range successful material chemistry. To expand library AIE-active TPEs,...
Abstract New β‐hydroxy nitrates have been synthesized by the ring‐opening reaction of epoxides with Bi(NO 3 ) · 5H 2 O, which was used both as a catalyst and reagent. The molecules are potential cyclitol mimetics vasodilators result their hydroxy groups nitrate esters. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)