A5073845953- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Reproductive System and Pregnancy
- Per- and polyfluoroalkyl substances research
- Pituitary Gland Disorders and Treatments
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Aldose Reductase and Taurine
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Pregnancy and Medication Impact
- Blood disorders and treatments
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Retinoids in leukemia and cellular processes
- Potato Plant Research
- Apelin-related biomedical research
- Caveolin-1 and cellular processes
- Mycotoxins in Agriculture and Food
- Renal Diseases and Glomerulopathies
- Metabolism, Diabetes, and Cancer
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Zhejiang University
2013
Women's Hospital, School of Medicine, Zhejiang University
2013
Endometriosis affects endometrial receptivity, a key factor for successful embryo implantation. Metformin treatment is associated with alleviating the symptoms of endometriosis; however mechanism metformin action unclear. Neoangiogenesis plays an important role in development and recurrence endometriosis. In addition, leukemia inhibitor (LIF) HOXA10 genes are also distinguishing markers endometriosis (decrease) receptivity (increase). This study investigated therapeutic potentials underlying using
Background The efficiency of prolonged down-regulation caused by a full-dose gonadotropin-releasing hormone agonist (GnRH-a) injected during different menstrual phases has not yet been researched. Our goal was to evaluate the effects GnRH-a, which used in cycle patients undergoing vitro fertilization and embryo transfer. Methods This retrospective cohort study. A total 320 received pituitary down-regulated (3.75 mg) triptorelin early follicular phase, 160 same mid-luteal phase. Clinical...
Per- and polyfluoroalkyl (PFAS) substances are enduring industrial materials. 17β-Hydroxysteroid dehydrogenase isoform 1 (17β-HSD1) is an estrogen metabolizing enzyme, which transforms estrone into estradiol in human placenta rat ovary. Whether PFAS inhibit 17β-HSD1 what the structure-activity relationship (SAR) remains unexplored. We screened 18 for inhibiting microsomes studied their SAR mode of action(MOA). Of 11 perfluorocarboxylic acids (PFCAs), C8-C14 PFCAs at a concentration 100 μM...
Perfluorotetradecanoic acid (PFTeDA) is a long-chain perfluoroalkyl compound with increased applications. Its effect on Leydig cell function and its underlying mechanism remain unclear. Male Sprague-Dawley rats (60 days old) were gavaged PFTeDA at doses of 0, 1, 5, 10 mg/kg/day from 60 to 87 after birth. significantly reduced serum testosterone levels 1 mg/kg higher doses, while markedly increasing luteinizing hormone level follicle-stimulating ≥1 mg/kg. the sperm number cauda epididymis...
BACKGROUND:This study investigated the effectiveness and feasibility of day 4 (D4) morula embryo transfer (ET) in comparison with 5 (D5) blastocyst ET, regards to their clinical data, laboratory test results, pregnancy outcomes. MATERIAL AND METHODS:This retrospective cohort enrolled 1070 patients, including 178 cases group D4 892 D5. The endpoint was live birth rate after fresh transfer. Furthermore, outcomes embryos different morphology were compared assigned 3 groups: 1 (n=66) compacted...
Backgroud This study’s objectives were to compare the clinical, perinatal, and obstetrical outcomes of patients with different estradiol (E 2 ) levels in fresh single-blastocyst-transfer (SBT) cycles under an early follicular phase prolonged regimen on day trigger. Methods We recruited SBT ( n = 771) undergoing protocols β-hCG values above 10 IU/L between June 2016 December 2018. Patients who met inclusion exclusion criteria divided into four groups according their serum E level percentages...
Perfluorotridecanoic acid (PFTrDA) is a long-chain (C13) perfluoroalkyl carboxylic acid. Here, we report the influence of PFTrDA exposure on maturation rat Leydig cells in late puberty vivo. Male Sprague–Dawley rats were administered by gavage 0, 1, 5, and 10 mg/kg/day from 35 days to 56 postpartum. had no effect body weight, testis epididymis weight. It significantly decreased serum testosterone level after 5 mg/kg exposure, while it did not alter estradiol level. The luteinizing hormone...
Abstract Perfluorotetradecanoic acid (PFTeDA) is a novel perfluoroalkyl substance that ubiquitously exists in the environment. However, whether PFTeDA affects adrenal cortex function remains unclear. Male Sprague–Dawley rats (age of 60 days) were daily administered with (0, 1, 5, and 10 mg/kg body weight) through gavage for 28 days. did not change gland weights. markedly elevated serum corticosterone level at but lowering aldosterone this dosage without influencing adrenocorticotropic...