A5071603669- Posttraumatic Stress Disorder Research
- Child Abuse and Trauma
- Migration, Health and Trauma
- Suicide and Self-Harm Studies
- Cerebral Palsy and Movement Disorders
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Maternal Mental Health During Pregnancy and Postpartum
- Resilience and Mental Health
- Genetics and Neurodevelopmental Disorders
- Neurogenetic and Muscular Disorders Research
- Congenital Heart Disease Studies
- Grief, Bereavement, and Mental Health
- Genomics and Rare Diseases
- Optimism, Hope, and Well-being
- Children's Physical and Motor Development
- Functional Brain Connectivity Studies
- LGBTQ Health, Identity, and Policy
- Occupational Health and Performance
- Neurological disorders and treatments
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Connective tissue disorders research
- Alcohol Consumption and Health Effects
- Attachment and Relationship Dynamics
University of Illinois Chicago
2019-2025
Northwestern University
2024
Abstract SCN2A-related disorders secondary to altered function in the voltage-gated sodium channel Nav1.2 are rare, with clinically heterogeneous expressions that include epilepsy, autism and multiple severe profound impairments other conditions. To advance understanding of clinical phenotypes their relationship function, 81 patients (36 female, 44%, median age 5.4 years) 69 unique SCN2A variants were systematically phenotyped assessed. Participants recruited through FamileSCN2A Foundation....
Purpose: The Vineland Adaptive Behavior Scales-3rd Edition (Vineland-3) is one of the most used measures adaptive behavior among those with sodium channel protein type 2 subunit alpha related disorders (SCN2A-RDs). Several disease-modifying treatments are in early trials for SCN2A-RDs, and as such, clinical outcome assessments (COAs) necessary. Vineland-3 introduced growth scale values (GSVs), which useful measuring within-person change thus may be future trials. purpose this study was to...
SCN2A-related disorders (RDs) are genetic conditions characterized by severe to profound impairments in multiple domains including gross motor function, which could serve as a nonseizure outcome precision medicine therapy trials. This study evaluated specific properties of the Vineland Adaptive Behavior Scales-3 (VABS3) and other assessments for their fitness use trials SCN2A-RDs. Sixty-five families recruited through FamileSCN2A foundation enrolled affected children ("participants," 28...
Theoretical models of trauma and alcohol use suggest that trauma-exposed individuals with higher levels PTSD symptoms are at increased risk problematic coping-oriented to alleviate unwanted internal states. The goal the current study was evaluate whether these associations enhanced among young adults who report engaging in impulsive behavior context negative affect (i.e., high urgency). It hypothesized (a) urgency would be associated use; (b) moderate association between use. Methods: This...
Attention-deficit/hyperactivity disorder (ADHD) is associated with various cognitive, behavioral, and mood symptoms that complicate diagnosis treatment. The heterogeneity of these may also vary depending on certain sociodemographic factors. It therefore important to establish more homogenous symptom profiles in patients ADHD determine their association the patient's makeup. current study used unsupervised machine learning identify across adults ADHD. was then examined whether differed based relevant
Abstract Background Clinical research indicates that successful posttraumatic stress disorder (PTSD) treatment does not lead to improvements in alcohol use outcomes comorbid PTSD and (AUD). Emerging theory suggests treating may disrupt an association between negative affect craving, which underlies reinforcement drinking. The goal of the current study was determine respective influences symptoms, coping motives, on trauma cue reactivity inform theoretical models co‐occurring AUD. Methods...
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Posttraumatic stress disorder (PTSD) and alcohol use (AUD) frequently co-occur, with elevated rates of both disorders in lesbian, gay, or bisexual (LGB) samples. Few studies have compared the strength PTSD-AUD associations between LGB heterosexual individuals evaluated role nontraumatic discrimination these relationships among sexual minorities. The current study utilized nationally representative epidemiological data (N = 29,646) to (a) examine whether lifetime trauma endorsement/PTSD...
Objective: Models of comorbid posttraumatic stress disorder (PTSD) and alcohol use (AUD) often emphasize negative reinforcement drinking (i.e., to reduce affect) as a key etiological maintenance factor. However, potential risk factors related in PTSD–AUD are less understood. Distress tolerance exhibits theoretical empirical promise one possible, malleable, The current study used trauma cue reactivity paradigm elucidate the role perceived self-reported) distress trauma-related risk. Method:...
High intensity (HI) binge drinking has emerged as a high-risk phenotype in young adult drinkers, yet few studies have evaluated clinically meaningful correlates of HI among adults at risk for co-occurring psychopathologies, such interpersonal trauma-exposed drinkers. The present study compared three groups (i.e., binge, standard non-binge drinkers) college student drinkers (N = 221) on alcohol and trauma characteristics. Results one-way ANOVAs indicated that the group endorsed significantly...
<sec> <title>BACKGROUND</title> Approximately 4% to 8% of pregnant individuals meet the criteria for current posttraumatic stress disorder (PTSD), a known risk factor multitude adverse maternal and child health outcomes. However, PTSD is rarely detected or treated in obstetric settings. Moreover, available prenatal treatments require in-person services that are often inaccessible due barriers care. Thus, web-based interventions offer great potential extending treatment high-risk by providing...
Objective: Continuous performance tests (CPT) are often considered the gold standard for diagnosis attention-deficit/hyperactivity disorder (ADHD), particularly when parent and teacher rating scales inconclusive. Prior work has indicated that CPT can also help differentiate between ADHD subtypes. However, ability of to subtype not been examined among youth with comorbid anxiety (ADHD+A). This is concerning as extant literature suggests symptoms may exacerbate deficits associated (e.g.. ,...
Objective: Deficits in visual-motor coordination and/or fine motor dexterity are often present pediatric neurological and neurodevelopmental conditions may adversely affect performance on tests with demands. This consideration is relevant when interpreting discrepant scores across Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) Processing Speed Index (PSI) subtests, specifically Symbol Search the more motorically demanding Coding. Although test developers maintain that...
Approximately 4% to 8% of pregnant individuals meet the criteria for current posttraumatic stress disorder (PTSD), a known risk factor multitude adverse maternal and child health outcomes. However, PTSD is rarely detected or treated in obstetric settings. Moreover, available prenatal treatments require in-person services that are often inaccessible due barriers care. Thus, web-based interventions offer great potential extending treatment high-risk by providing affordable, accessible there...